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AB77640

Anti-LYPLAL1 antibody

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(2 Publications)

Goat Polyclonal LYPLAL1 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human LYPLAL1 aa 50-100.

View Alternative Names

Lysophospholipase-like protein 1, LYPLAL1

1 Images
Western blot - Anti-LYPLAL1 antibody (AB77640)
  • WB

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Western blot - Anti-LYPLAL1 antibody (AB77640)

All lanes:

Western blot - Anti-LYPLAL1 antibody (ab77640) at 0.3 µg/mL

All lanes:

Human adipose lysate in RIPA buffer at 35 µg

Predicted band size: 26 kDa

Observed band size: 28 kDa

false

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human LYPLAL1 aa 50-100. The exact immunogen used to generate this antibody is proprietary information.

Q5VWZ2

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.3-1 µg/mL", "WB-species-notes": "<p>1 hour primary incubation is recommended for this product.</p>" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Chimpanzee": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Macaque monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab77640 was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: Tris buffered saline, 0.5% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle|Store in the dark
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LYPLAL1 also known as Lysophospholipase-like 1 is a protein involved in metabolic processes and has an approximate molecular mass of 31 kDa. This protein is expressed in various tissues with substantial levels found in adipose tissue and the liver. LYPLAL1 shows similarity to lysophospholipase enzymes but lacks the capacity to carry out specific functions typical of those enzymes. Instead LYPLAL1 contributes mechanically by modifying certain lipid molecules impacting lipid metabolism.
Biological function summary

Lysophospholipase-like 1 influences fat storage and energy homeostasis within cells. It does not function alone but rather interacts potentially with other enzymes to regulate these processes. While LYPLAL1 itself is not part of a large complex it operates in an environment with various lipid-related enzymes that jointly maintain lipid balance in the body. Its activity can affect the breakdown of triglycerides and might have roles in metabolic regulation and efficiency.

Pathways

LYPLAL1 integrates into lipid metabolic pathways notably lipid biosynthesis and lipid degradation. These pathways are central in balancing energy supply through the manipulation and storage of lipid molecules. Through these metabolic pathways LYPLAL1 may have connections with proteins such as hormone-sensitive lipase (HSL) which plays a significant role in lipid mobilization and perilipin which modulates lipid droplet storage. The regulation and interaction with these proteins affirm LYPLAL1's place in lipid metabolism.

Variations in LYPLAL1 activity or expression have links with obesity and type 2 diabetes. The gene coding for LYPLAL1 has associations with variations impacting body mass index (BMI) and fat distribution which are critical factors in these metabolic disorders. Connections with other proteins like adiponectin which plays an important role in glucose regulation and fatty acid oxidation strengthen LYPLAL1’s involvement in these diseases. Understanding the relationship of LYPLAL1 to these conditions offers new insights into metabolic health management strategies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Palmitoyl thioesterase that catalyzes depalmitoylation of CGAS and KCNMA1 (PubMed : 22052940, PubMed : 22399288, PubMed : 37802025). Acts as a regulator of innate immunity by mediating depalmitoylation of CGAS, thereby preventing CGAS homodimerization and cyclic GMP-AMP synthase activity (PubMed : 37802025). Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site (PubMed : 22052940).
See full target information LYPLAL1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Cell 176:805-815.e8 PubMed30639102

2019

Importin α Partitioning to the Plasma Membrane Regulates Intracellular Scaling.

Applications

Unspecified application

Species

Unspecified reactive species

Christopher Brownlee,Rebecca Heald

PLoS genetics 8:e1002753 PubMed22685421

2012

Genetic variants on chromosome 1q41 influence ocular axial length and high myopia.

Applications

IHC-Fr

Species

Mouse

Qiao Fan,Veluchamy A Barathi,Ching-Yu Cheng,Xin Zhou,Akira Meguro,Isao Nakata,Chiea-Chuen Khor,Liang-Kee Goh,Yi-Ju Li,Wan'e Lim,Candice E H Ho,Felicia Hawthorne,Yingfeng Zheng,Daniel Chua,Hidetoshi Inoko,Kenji Yamashiro,Kyoko Ohno-Matsui,Keitaro Matsuo,Fumihiko Matsuda,Eranga Vithana,Mark Seielstad,Nobuhisa Mizuki,Roger W Beuerman,E-Shyong Tai,Nagahisa Yoshimura,Tin Aung,Terri L Young,Tien-Yin Wong,Yik-Ying Teo,Seang-Mei Saw
View all publications
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