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AB106686

Anti-LYRM2 antibody

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(2 Publications)

Rabbit Polyclonal LYRM2 antibody. Suitable for ICC, WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human LYRM2.

View Alternative Names

LYR motif-containing protein 2, LYRM2

3 Images
Immunocytochemistry - Anti-LYRM2 antibody (AB106686)
  • ICC

Unknown

Immunocytochemistry - Anti-LYRM2 antibody (AB106686)

Immunocytochemical analysis of LYRM2 in A549 cells, using ab106686 at 20 µg/ml.

Immunocytochemistry/ Immunofluorescence - Anti-LYRM2 antibody (AB106686)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-LYRM2 antibody (AB106686)

Immunofluorescence of LYRM2 in A549 cells with ab106686 at 20 ug/mL.

Western blot - Anti-LYRM2 antibody (AB106686)
  • WB

Unknown

Western blot - Anti-LYRM2 antibody (AB106686)

Lane 1:

Western blot - Anti-LYRM2 antibody (ab106686) at 1 µg/mL

Lane 2:

Western blot - Anti-LYRM2 antibody (ab106686) at 2 µg/mL

All lanes:

A549 cell lysate at 15 µg

Predicted band size: 10 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, ICC/IF, ICC

applications

Immunogen

Synthetic Peptide within Human LYRM2. The exact immunogen used to generate this antibody is proprietary information.

Q9NU23

Specificity

ab106686 is predicted not to crossreact with other LYRM family members.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICC" : {"fullname" : "Immunocytochemistry", "shortname":"ICC"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICC-species-checked": "testedAndGuaranteed", "ICC-species-dilution-info": "20 µg/mL", "ICC-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "20 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Affinity chromatography purified via peptide column.
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
Up to 12 months
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LYRM2 also known as lipoamide acyltransferase.using mitochondrial protein 2 is a small protein consisting of 111 amino acids with a mass of approximately 12 kDa. It is expressed primarily in the mitochondria of cells where it takes part in the formation and function of the mitochondrial RNA-processing enzyme complex. LYRM2 influences processes within mitochondria by ensuring proper enzymatic activity. The protein shows expression in various tissues which implicates its role in several cellular functions across different cell types.
Biological function summary

LYRM2 operates within the mitochondria where it links to enzymes associated with the synthesis and function of mitochondrial proteins. It is a member of the Lyr family of mitochondrial proteins and is part of a complex that includes mitochondrial acyltransferases. This association indicates an involvement with mitochondrial respiratory chain functions contributing to proper cellular energy metabolism. The protein stabilizes the acyltransferase components assisting in the regulation of mitochondrial enzyme activity.

Pathways

LYRM2 contributes significantly to the mitochondrial respiratory chain pathway and the regulation of mitochondrial protein synthesis. It interacts closely with other proteins like LYRM5 and components of the mitochondrial pyruvate dehydrogenase complex. LYRM2's association with these key proteins ensures efficient performance of the respiratory chain supporting ATP production. Its activity supports the overall energy balance within cells and affects cellular respiration efficiency.

LYRM2 has associations with mitochondrial disorders like Leigh syndrome and other conditions involving dysfunctional mitochondrial energy metabolism. Dysfunctional LYRM2 expression may result in impaired energy production which can exacerbate symptoms of mitochondrial diseases. The protein is connected to the disease mechanism through its interaction with critical proteins like NDUFS6 another mitochondrial complex component. Dysregulation of LYRM2 can impact cellular ATP levels contributing to the neurological and muscular symptoms observed in these disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Involved in efficient integration of the N-module into mitochondrial respiratory chain complex I.
See full target information LYRM2
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Journal of cellular and molecular medicine 28:e70241 PubMed39661026

2024

LYRM2 Promotes the Growth and Metastasis of Hepatocellular Carcinoma via Enhancing HIF-1α-Dependent Glucose Metabolic Reprogramming.

Applications

Unspecified application

Species

Unspecified reactive species

Bingfu Fan,Yueqin Zhang,Lu Zhou,Zhongchun Xie,Jie Liu,Chengwu Zhang,Changwei Dou

Frontiers in physiology 11:572605 PubMed33551826

2021

Long Non-coding RNA MIAT Knockdown Prevents the Formation of Intracranial Aneurysm by Downregulating ENC1 via MYC.

Applications

Unspecified application

Species

Unspecified reactive species

Xinguo Li,Hang Zhao,Jihui Liu,Jing Tong
View all publications
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