JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB151089

Anti-LYRM7 antibody

Be the first to review this product! Submit a review

|

(2 Publications)

Rabbit Polyclonal LYRM7 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human LYRM7 aa 1 to C-terminus.

View Alternative Names

C5orf31, MZM1L, LYRM7, Complex III assembly factor LYRM7, LYR motif-containing protein 7

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYRM7 antibody (AB151089)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYRM7 antibody (AB151089)

Immunohistochemical analysis of paraffin-embedded Human testis tissue labeling LYRM7 with ab151089 at 1/500 dilution.

Western blot - Anti-LYRM7 antibody (AB151089)
  • WB

Unknown

Western blot - Anti-LYRM7 antibody (AB151089)

All lanes:

Western blot - Anti-LYRM7 antibody (ab151089) at 0.4 µg/mL

All lanes:

Human cell line HDLM-2

Predicted band size: 12 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human LYRM7 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q5U5X0

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/1000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>" } } }
style
left-column

Product details

The antibody solution should be gently mixed before use.
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LYRM7 also known as LYR motif-containing protein 7 has a mechanical role in mitochondrial function. This protein has a mass of approximately 13 kDa and is expressed mainly in the mitochondria of cells. It interacts closely with components of the mitochondrial complex making it integral to mitochondrial activity. Researchers have identified alternative names like BNF1 and MET7 for LYRM7 highlighting its diverse functions in different contexts.
Biological function summary

LYRM7 incorporates into the mitochondrial complex I an important component for cellular respiration. The protein contributes to the assembly of the mitochondrial complex ensuring proper cellular energy production. As part of the LYRM family of proteins LYRM7 facilitates interactions with NADH:ubiquinone oxidoreductase enhancing the efficiency of electron transport within mitochondria. This role associates LYRM7 with maintaining energy balance essential for normal cellular operations.

Pathways

LYRM7 plays a role in the mitochondrial electron transport chain and the oxidative phosphorylation pathway. LYRM7 is essential for the biogenesis of mitochondrial complex I working closely with other proteins like NDUFS2 which is a core complex I subunit. LYRM7’s function in these pathways ensures efficient electron transport and ATP production linking it to energy metabolism processes necessary for cellular and organ function.

Researchers have linked LYRM7 to mitochondrial complex I deficiency and Leigh syndrome. Patients with deficiencies in LYRM7 or related proteins like NDUFS2 experience disruptions in cellular respiration leading to severe metabolic disorders. Leigh syndrome a neurodegenerative disorder often arises from defects in mitochondrial energy production pathways with LYRM7 having a significant connection due to its role within the mitochondrial complex. Understanding LYRM7 and related proteins can provide insights into potential therapeutic targets for these diseases.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane.
See full target information LYRM7
style
left-column

Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in immunology 14:1268141 PubMed38035073

2023

A comprehensive cuproptosis score and associated gene signatures reveal prognostic and immunological features of idiopathic pulmonary fibrosis.

Applications

Unspecified application

Species

Unspecified reactive species

Chuanqing Jing,Rong Fu,Xue Liu,Guodong Zang,Xue Zhu,Can Wang,Wei Zhang

Molecular therapy. Nucleic acids 22:640-656 PubMed33230463

2020

TNFAIP8 Promotes Cisplatin Chemoresistance in Triple-Negative Breast Cancer by Repressing p53-Mediated miR-205-5p Expression.

Applications

Unspecified application

Species

Unspecified reactive species

Hong-Yu Ma,Yang Li,Hui-Zi Yin,Hang Yin,Yuan-Yuan Qu,Qing-Yong Xu
View all publications
style
left-column
style
left-column
style
right-column

Complementary Products

Primary Antibodies

AB184774

Anti-PAIP2B antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PAIP2B antibody (AB184774)

  • 0
  • 0
Primary Antibodies

AB126356

Anti-WWC2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-WWC2 antibody (AB126356)

  • 0
  • 0
Primary Antibodies

AB223477

Anti-ZKSCAN3 antibody

Immunocytochemistry/ Immunofluorescence - Anti-ZKSCAN3 antibody (AB223477)

  • 0
  • 0
Primary Antibodies

AB184772

Anti-URG11 antibody

Immunocytochemistry/ Immunofluorescence - Anti-URG11 antibody (AB184772)

  • 4
  • 2

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com