AB34799

Anti-Lysozyme antibody

Name: Anti-Lysozyme antibody (ab34799) | Abcam
Brand: Abcam Limited
SKU: AB34799
Rating: 3 (1 reviews)

(1 Review)

(2 Publications)

Rabbit Polyclonal Lysozyme antibody. Suitable for WB and reacts with Recombinant full length protein - Chicken samples. Cited in 2 publications. Immunogen corresponding to Native Full Length Protein corresponding to Chicken LYZ.

View Alternative Names

Lysozyme C, Allergen Gal d IV, LYZ

1 Images

Supplier Data

Western blot - Anti-Lysozyme antibody (AB34799)

All lanes:

Western blot - Anti-Lysozyme antibody (ab34799) at 1/1000 dilution

All lanes:

Lysozyme at 0.01 µg

Secondary

All lanes:

Goat anti-rabbit DyLight 649 at 1/20000 dilution

Predicted band size: 16 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Chicken

Applications

applications

Immunogen

Native Full Length Protein corresponding to Chicken LYZ.

P00698

Specificity

Cross reactivity against Lysozyme from other tissues and species may occur but have not been specifically determined.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Chicken": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Recombinant full length protein - Chicken": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification notes

Purified from monospecific antiserum by a delipidation and defibrination.

Storage buffer

Preservative: 0.01% Sodium azide Constituents: 0.88% Sodium chloride, 0.424% Potassium phosphate solution

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Lysozyme also known as muramidase is a protein with enzymatic activity that breaks down bacterial cell walls by hydrolyzing the glycosidic bonds of peptidoglycan. The molecular weight of lysozyme is approximately 14 kDa. This protein is expressed in various tissues and body fluids including egg whites human saliva tears and milk. Lysozyme acts as an antimicrobial agent and plays a significant role in the innate immune system.

Biological function summary

Lysozyme contributes to host defense by targeting bacteria. It is not part of a complex but functions as a single enzyme. By compromising the integrity of bacterial cell walls it clears pathogens swiftly from the body. Lysozyme activity assays measure its ability to hydrolyze bacterial peptidoglycan reflecting its role in immune defense. Many cells such as neutrophils and macrophages express lysozyme during the immune response aiding in pathogen clearance.

Pathways

Lysozyme is chiefly involved in the antibacterial humoral response pathway. Its action aligns with other antimicrobial proteins such as lactoferrin. Both lysozyme and lactoferrin are integral to the body’s first line of defense against bacterial invasion. In addition lysozyme is relevant in the pathway managing mucosal immunity working in conjunction with proteins that enhance pathogen clearance like defensins.

Lysozyme has links to conditions such as sarcoidosis and hereditary renal amyloidosis. In sarcoidosis altered expression patterns of lysozyme may serve as a marker for disease activity. In hereditary renal amyloidosis mutations in the lysozyme gene result in amyloid fibril formation leading to renal dysfunction. Understanding these connections helps in the diagnosis and treatment of related conditions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.

See full target information LYZ

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Journal of lipid research 51:3126-34 PubMed20724654

2010

Interaction of phospholipid transfer protein with human tear fluid mucins.

Applications

Species

Human

Niko L Setälä,Juha M Holopainen,Jari Metso,Gebrenegus Yohannes,Jaakko Hiidenhovi,Leif C Andersson,Ove Eriksson,Alexandra Robciuc,Matti Jauhiainen

Biochimica et biophysica acta 1804:1272-84 PubMed20152940

2010

Protein disulfide isomerase-P5, down-regulated in the final stage of boar epididymal sperm maturation, catalyzes disulfide formation to inhibit protein function in oxidative refolding of reduced denatured lysozyme.

Applications

Unspecified application

Species

Unspecified reactive species

Kuniko Akama,Tomoe Horikoshi,Atsushi Sugiyama,Satoko Nakahata,Aoi Akitsu,Nobuyoshi Niwa,Atsushi Intoh,Yasutaka Kakui,Michiko Sugaya,Kazuo Takei,Noriaki Imaizumi,Takaya Sato,Rena Matsumoto,Hitoshi Iwahashi,Shin-ichi Kashiwabara,Tadashi Baba,Megumi Nakamura,Tosifusa Toda

View all publications

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Product promise

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