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AB234194

Anti-Lysozyme antibody [LZ598-10G9]

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(1 Publication)

Mouse Monoclonal Lysozyme antibody. Suitable for ICC/IF, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.

View Alternative Names

LZM, LYZ, Lysozyme C

3 Images
Flow Cytometry (Intracellular) - Anti-Lysozyme antibody [LZ598-10G9] (AB234194)
  • Flow Cyt (Intra)

Supplier Data

Flow Cytometry (Intracellular) - Anti-Lysozyme antibody [LZ598-10G9] (AB234194)

Intracellular staining (mass cytometry) of PBMC (after Ficoll-Paque separation) with ab234194. Gated on native.

Immunocytochemistry - Anti-Lysozyme antibody [LZ598-10G9] (AB234194)
  • ICC

Supplier Data

Immunocytochemistry - Anti-Lysozyme antibody [LZ598-10G9] (AB234194)

Immunocytochemistry analysis of HepG2 (human liver hepatocellular carcinoma cell line) cells (Images A, B, C) labeling Lysozyme with ab234194. Actin decorated with phalloidin (red), DNA stained with DAPI (blue).

Image D : SK-BR-3 (human mammary gland adenocarcinoma cell line) cells with no expression of lysozyme, stained with ab234194 (no background signal).

Flow Cytometry (Intracellular) - Anti-Lysozyme antibody [LZ598-10G9] (AB234194)
  • Flow Cyt (Intra)

Supplier Data

Flow Cytometry (Intracellular) - Anti-Lysozyme antibody [LZ598-10G9] (AB234194)

Intracellular staining of Lysozyme in human peripheral blood with ab234194 followed by a Goat anti-mouse-FITC conjugated secondary.

  • 519 FITC

    FITC Anti-Lysozyme antibody [LZ598-10G9]

  • 578 PE

    PE Anti-Lysozyme antibody [LZ598-10G9]

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

LZ598-10G9

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

Flow Cyt (Intra), ICC/IF

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "FlowCytIntra" : {"fullname" : "Flow Cytometry (Intracellular)", "shortname":"Flow Cyt (Intra)"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>", "FlowCytIntra-species-checked": "testedAndGuaranteed", "FlowCytIntra-species-dilution-info": "1-12 µg/mL", "FlowCytIntra-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Purification notes
Purity is >95% by SDS-PAGE.
Storage buffer
pH: 7.4 Preservative: 0.0975% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Lysozyme also known as muramidase is a protein with enzymatic activity that breaks down bacterial cell walls by hydrolyzing the glycosidic bonds of peptidoglycan. The molecular weight of lysozyme is approximately 14 kDa. This protein is expressed in various tissues and body fluids including egg whites human saliva tears and milk. Lysozyme acts as an antimicrobial agent and plays a significant role in the innate immune system.
Biological function summary

Lysozyme contributes to host defense by targeting bacteria. It is not part of a complex but functions as a single enzyme. By compromising the integrity of bacterial cell walls it clears pathogens swiftly from the body. Lysozyme activity assays measure its ability to hydrolyze bacterial peptidoglycan reflecting its role in immune defense. Many cells such as neutrophils and macrophages express lysozyme during the immune response aiding in pathogen clearance.

Pathways

Lysozyme is chiefly involved in the antibacterial humoral response pathway. Its action aligns with other antimicrobial proteins such as lactoferrin. Both lysozyme and lactoferrin are integral to the body's first line of defense against bacterial invasion. In addition lysozyme is relevant in the pathway managing mucosal immunity working in conjunction with proteins that enhance pathogen clearance like defensins.

Lysozyme has links to conditions such as sarcoidosis and hereditary renal amyloidosis. In sarcoidosis altered expression patterns of lysozyme may serve as a marker for disease activity. In hereditary renal amyloidosis mutations in the lysozyme gene result in amyloid fibril formation leading to renal dysfunction. Understanding these connections helps in the diagnosis and treatment of related conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.
See full target information LYZ
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell reports 40:111423 PubMed36170817

2022

Engineering of immune checkpoints B7-H3 and CD155 enhances immune compatibility of MHC-I iPSCs for β cell replacement.

Applications

Unspecified application

Species

Unspecified reactive species

Raniero Chimienti,Tania Baccega,Silvia Torchio,Fabio Manenti,Silvia Pellegrini,Alessandro Cospito,Angelo Amabile,Marta Tiffany Lombardo,Paolo Monti,Valeria Sordi,Angelo Lombardo,Mauro Malnati,Lorenzo Piemonti
View all publications
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Product promise

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