Anti-LYVE1 antibody is a rabbit polyclonal antibody that is used to detect LYVE1 in ICC/IF, IHC-P. Suitable for Mouse samples.
- Cited in over 45 publications
- Tried and trusted by researchers since 2007
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Publications
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- Frontiers in cell and developmental biology 11:12283442023Widespread distribution of lymphatic vessels in human dura mater remote from sinus veins.Applications:Unspecified applicationReactive species:Unspecified reactive speciesCésar Luis Vera Quesada,Shreyas Balachandra Rao,Reidun Torp,Per Kristian EidePubMed 37795263
- Cells 12:2023Lymphatic Endothelial-to-Myofibroblast Transition: A Potential New Mechanism Underlying Skin Fibrosis in Systemic Sclerosis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesIrene Rosa,Eloisa Romano,Bianca Saveria Fioretto,Khadija El Aoufy,Silvia Bellando-Randone,Marco Matucci-Cerinic,Mirko ManettiPubMed 37681927
- PLoS pathogens 19:e10114602023L-selectin-dependent and -independent homing of naïve lymphocytes through the lung draining lymph node support T cell response to pulmonary Mycobacterium tuberculosis infection.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLina Daniel,Claudio Counoupas,Nayan D Bhattacharyya,James A Triccas,Warwick J Britton,Carl G FengPubMed 37405965
- Journal of plastic surgery and hand surgery 58:40-472023Short term treatment of secondary lymphedema with hyaluronidase injections reduces mouse hindlimb lymphedema.Applications:Unspecified applicationReactive species:Unspecified reactive speciesFarima Dalaei,Amar Bucan,Alexander Wiinholt,Mads Gustaf Jørgensen,Christian Rønn Hansen,Christina Baun,Svend Hvidsten,Eva Kildall Hejbøl,Henrik Daa Schrøder,Jens Ahm SørensenPubMed 37338078
- Cancer gene therapy 30:1260-12732023ANRIL promotes the regulation of colorectal cancer on lymphatic endothelial cells via VEGF-C and is the key target for Pien Tze Huang to inhibit cancer metastasis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesBin Huang,Yao Lu,Zhuona Ni,Jinhong Liu,Yanbin He,Honglin An,Feimin Ye,Jiayu Shen,Minghe Lin,Yong Chen,Jiumao LinPubMed 37286729
- Arthritis & rheumatology (Hoboken, N.J.) 75:950-9602023Knee Alignment Correction by High Tibial Osteotomy Reduces Symptoms and Synovial Inflammation in Knee Osteoarthritis Accompanied by Macrophage Phenotypic Change From M1 to M2.Applications:Unspecified applicationReactive species:Unspecified reactive speciesShigeo Yoshida,Kohei Nishitani,Hiroyuki Yoshitomi,Shinichi Kuriyama,Shinichiro Nakamura,Takayuki Fujii,Motoo Saito,Yu Kobori,Akinori Murakami,Koichi Murata,Hiromu Ito,Hideki Ueno,Shuichi MatsudaPubMed 36530127
- American journal of reproductive immunology (New York, N.Y. : 1989) 89:e136782023Individual variation in and lateral asymmetry of mouse epididymal draining lymph nodes.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJing Peng,Huixi Li,Shaojun Yang,Xuyuan Zhang,Patrick Z Li,Xiaohua Nie,Liguo Zhang,Zhichao ZhangPubMed 36648083
- Frontiers in immunology 13:10908772022Piperlongumine alleviates corneal allograft rejection suppressing angiogenesis and inflammation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXiangyu Fan,Jini Qiu,Tianjie Yuan,Jing Zhang,Jianjiang XuPubMed 36591243
- Nature communications 13:65922022JAK2V617F mutation drives vascular resident macrophages toward a pathogenic phenotype and promotes dissecting aortic aneurysm.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRida Al-Rifai,Marie Vandestienne,Jean-Rémi Lavillegrand,Tristan Mirault,Julie Cornebise,Johanne Poisson,Ludivine Laurans,Bruno Esposito,Chloé James,Olivier Mansier,Pierre Hirsch,Fabrizia Favale,Rayan Braik,Camille Knosp,Jose Vilar,Giuseppe Rizzo,Alma Zernecke,Antoine-Emmanuel Saliba,Alain Tedgui,Maxime Lacroix,Lionel Arrive,Ziad Mallat,Soraya Taleb,Marc Diedisheim,Clément Cochain,Pierre-Emmanuel Rautou,Hafid Ait-OufellaPubMed 36329047
- Cells 11:2022Vascular Remodeling Is a Crucial Event in the Early Phase of Hepatocarcinogenesis in Rodent Models for Liver Tumorigenesis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMargaret Tulessin,Rim Sabrina Jahan Sarker,Joscha Griger,Thomas Leibing,Cyrill Geraud,Wilko Weichert,Katja Steiger,Carolin MoglerPubMed 35883572
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 98.98% PBS, 1% BSA- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
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Reactivity data
Select an application| ICC/IF | WB | IHC-P | |
|---|---|---|---|
| Human | Not recommended | Not recommended | Not recommended |
| Mouse | Expected | Not recommended | Tested |
| Cow | Not recommended | Not recommended | Not recommended |
| Pig | Not recommended | Not recommended | Not recommended |
ICC/IF
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 5 µg/mL | Notes - |
Not recommendedNot recommended
| Species | Dilution info | Notes |
|---|---|---|
Species Human, Cow, Pig | Dilution info - | Notes - |
WB
Not recommendedNot recommended
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Human, Cow, Pig | Dilution info - | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 5 µg/mL | Notes - |
Not recommendedNot recommended
| Species | Dilution info | Notes |
|---|---|---|
Species Human, Cow, Pig | Dilution info - | Notes - |
Associated Products
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Target data
Function
Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes (PubMed:10037799). Binds to pericelluar hyaluronan matrices deposited on the surface of leukocytes and facilitates cell adhesion and migration through lymphatic endothelium (PubMed:26823460).
Alternative names
CRSBP1, HAR, XLKD1, UNQ230/PRO263, LYVE1, Lymphatic vessel endothelial hyaluronic acid receptor 1, LYVE-1, Cell surface retention sequence-binding protein 1, Extracellular link domain-containing protein 1, Hyaluronic acid receptor, CRSBP-1
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Anti-LYVE1 antibody is a rabbit polyclonal antibody that is used to detect LYVE1 in ICC/IF, IHC-P. Suitable for Mouse samples.
- Cited in over 45 publications
- Tried and trusted by researchers since 2007
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 98.98% PBS, 1% BSA- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
- Purification technique
- Affinity purification Immunogen
- Specificity
From July 2024, QC testing of replenishment batches of this polyclonal changed. All tested and expected application and reactive species combinations are still covered by our Abcam product promise. However, we no longer test all applications. For more information on a specific batch, please contact our Scientific Support who will be happy to help.
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Anti-LYVE1 antibody (ab33682) is a rabbit polyclonal antibody and is validated for use in ICC, IHC-P in mouse samples.
Anti-LYVE1 antibody (ab33682) has been cited over 47 times in peer reviewed journals and is trusted by the scientific community.
Abcam's high quality validation processes ensure Anti-LYVE1 antibody (ab33682) has high sensitivity and specificity.
Anti-LYVE1 antibody (ab33682) has 12 independent reviews from customers.
Anti-LYVE1 antibody (ab33682) specifically detects LYVE1 (UniProt ID: Q9Y5Y7; Molecular weight: 33kDa) and is sold in 100 µg selling sizes.
LYVE-1 (Lymphatic Vessel Endothelial Receptor 1) is primarily expressed on lymphatic endothelial cells and plays a crucial role in hyaluronan (HA) transport and turnover. It is also involved in lymphangiogenesis and immune responses, with altered LYVE-1 expression linked to various diseases, including cancer and inflammatory conditions. For instance, LYVE-1 expression is downregulated in human liver cancer and cirrhosis. Additionally, it is linked to intramuscular hemangioma and complete androgen insensitivity syndrome. Changes in LYVE-1 expression can impact lymphangiogenesis and immune responses, contributing to disease progression.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The protein "LYVE1" also known as Lymphatic Vessel Endothelial Hyaluronan Receptor 1 has a molecular mass of about 60 kDa. This protein is located on the surface of lymphatic endothelial cells. Its expression occurs mainly within the lymphatic vessels serving as an important marker for identifying lymphatic endothelium. LYVE1 facilitates the transportation of hyaluronan an important glycosaminoglycan through lymphatic vessels playing a critical role in the maintenance of extracellular matrix and tissue fluid homeostasis.
- Biological function summary
LYVE1 plays a role in lymphatic system regulation and immune cell trafficking. It forms part of a network that binds hyaluronan contributing to the regulation of cell migration and adhesion. This protein interacts with molecules like CD44 and other receptors which also participate in hyaluronan binding. LYVE1's function in maintaining the balance of hyaluronan within tissues is central affecting not only the lymphatic system but also immune responses.
- Pathways
LYVE1 engages in both the hyaluronan metabolism and lymphangiogenesis pathways. Its interaction with CD44 plays a significant role in the transport and uptake of hyaluronan influencing cellular processes such as proliferation and motility. These interactions link LYVE1 to pathways controlling fluid balance and immune surveillance marking it as essential for maintaining healthy lymphatic and immune function.
- Associated diseases and disorders
LYVE1 shows a connection to lymphatic-related conditions such as lymphedema and cancer metastasis. Alterations or dysregulation of LYVE1 expression can affect lymphatic function potentially leading to the accumulation of interstitial fluid as seen in lymphedema. In cancer increased LYVE1 expression can relate to tumor metastasis where it functions alongside proteins like VEGFR-3 in promoting lymphatic vessel growth and facilitating cancer cell spread.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
1 product image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYVE1 antibody (ab33682)
IHC image of LYVE1 staining in a section of formalin-fixed paraffin-embedded normal mouse large intestine performed on a Leica BONDTM system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 minutes. The section was then incubated with ab33682, 1 μg/mL, for 15 minutes at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. The inset secondary-only control image is taken from an identical assay without primary antibody.
For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.
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