Anti-LYVE1 antibody is a rabbit polyclonal antibody that is provided free from BSA and azide, and is conjugation-ready. It is used in LYVE1 IHC and immunocytochemistry/immunofluorescence (ICC/IF). Suitable for mouse samples.
- Cited in over 285 publications
- PBS only, removing anything extra from your antibodies, greater flexibility in assay design
- Affinity purified using Protein A
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- JCI insight 9:2024Efficient pulmonary lymphatic drainage is necessary for inflammation resolution in ARDS.Applications:Unspecified applicationReactive species:Unspecified reactive speciesPu-Hong Zhang,Wen-Wu Zhang,Shun-Shun Wang,Cheng-Hua Wu,Yang-Dong Ding,Xin-Yi Wu,Fang Gao Smith,Yu Hao,Sheng-Wei JinPubMed 37971881
- eLife 12:2023Apoptosis recognition receptors regulate skin tissue repair in mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesOlivia Justynski,Kate Bridges,Will Krause,Maria Fernanda Forni,Quan M Phan,Teresa Sandoval-Schaefer,Kristyn Carter,Diane E King,Henry C Hsia,Michael I Gazes,Steven D Vyce,Ryan R Driskell,Kathryn Miller-Jensen,Valerie HorsleyPubMed 38127424
- Fluids and barriers of the CNS 20:932023Structural characterization of SLYM-a 4th meningeal membrane.Applications:Unspecified applicationReactive species:Unspecified reactive speciesVirginia Plá,Styliani Bitsika,Michael J Giannetto,Antonio Ladron-de-Guevara,Daniel Gahn-Martinez,Yuki Mori,Maiken Nedergaard,Kjeld MøllgårdPubMed 38098084
- Nature 623:792-8022023CD201 fascia progenitors choreograph injury repair.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDonovan Correa-Gallegos,Haifeng Ye,Bikram Dasgupta,Aydan Sardogan,Safwen Kadri,Ravinder Kandi,Ruoxuan Dai,Yue Lin,Robert Kopplin,Disha Shantaram Shenai,Juliane Wannemacher,Ryo Ichijo,Dongsheng Jiang,Maximilian Strunz,Meshal Ansari,Illias Angelidis,Herbert B Schiller,Thomas Volz,Hans-Günther Machens,Yuval RinkevichPubMed 37968392
- Nature communications 14:70482023Wnt activation disturbs cell competition and causes diffuse invasion of transformed cells through NF-κB-MMP21 pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKazuki Nakai,Hancheng Lin,Shotaro Yamano,Shinya Tanaka,Sho Kitamoto,Hitoshi Saitoh,Kenta Sakuma,Junpei Kurauchi,Eilma Akter,Masamitsu Konno,Kojiro Ishibashi,Ryo Kamata,Akihiro Ohashi,Jun Koseki,Hirotaka Takahashi,Hideshi Yokoyama,Yukihiro Shiraki,Atsushi Enomoto,Sohei Abe,Yoku Hayakawa,Tetsuo Ushiku,Michihiro Mutoh,Yasuyuki Fujita,Shunsuke KonPubMed 37923722
- Nature communications 14:70602023Lipofuscin-like autofluorescence within microglia and its impact on studying microglial engulfment.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJacob M Stillman,Francisco Mendes Lopes,Jing-Ping Lin,Kevin Hu,Daniel S Reich,Dorothy P SchaferPubMed 37923732
- The Journal of clinical investigation 134:2023Piezo1 agonist restores meningeal lymphatic vessels, drainage, and brain-CSF perfusion in craniosynostosis and aged mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMatt J Matrongolo,Phillip S Ang,Junbing Wu,Aditya Jain,Joshua K Thackray,Akash Reddy,Chi Chang Sung,Gaëtan Barbet,Young-Kwon Hong,Max A TischfieldPubMed 37917195
- PloS one 18:e02926632023Hydrogen sulfide donor activates AKT-eNOS signaling and promotes lymphatic vessel formation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRavi Varma Aithabathula,Naveed Pervaiz,Ishita Kathuria,Mallory Swanson,Udai P Singh,Santosh Kumar,Frank Park,Bhupesh SinglaPubMed 37883422
- Molecular medicine reports 28:2023Inhibition of TP signaling promotes endometriosis growth and neovascularization.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAkiko Furue,Kyoko Hattori,Kanako Hosono,Mina Tanabe,Erina Sato,Masako Honda,Kazuki Sekiguchi,Yoshiya Ito,Masataka Majima,Shuh Narumiya,Kazuyoshi Kato,Hideki AmanoPubMed 37654213
- Theranostics 13:4182-41962023Endothelial TAZ inhibits capillarization of liver sinusoidal endothelium and damage-induced liver fibrosis nitric oxide production.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJun-Ha Hwang,Woong Heo,Jung Il Park,Kyung Min Kim,Ho Taek Oh,Gi Don Yoo,Jeekeon Park,Somin Shin,Youjin Do,Mi Gyeong Jeong,Eun Sook Hwang,Jeong-Ho HongPubMed 37554269
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Constituents: PBS
- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Mouse Lyve1 aa 1-250. The exact immunogen used to generate this antibody is proprietary information. Database link Q8BHC0
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Reactivity data
Select an application| ICC | IHC-P | |
|---|---|---|
| Mouse | Tested | Tested |
ICC
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info - | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info - | Notes - |
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Target data
Function
Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes (PubMed:10187853). Binds to pericelluar hyaluronan matrices deposited on the surface of leukocytes and facilitates cell adhesion and migration through lymphatic endothelium (By similarity).
Alternative names
Crsbp1, Xlkd1, Lyve1, Lymphatic vessel endothelial hyaluronic acid receptor 1, LYVE-1, Cell surface retention sequence-binding protein 1, Extracellular link domain-containing protein 1, CRSBP-1
Recommended products
Anti-LYVE1 antibody is a rabbit polyclonal antibody that is provided free from BSA and azide, and is conjugation-ready. It is used in LYVE1 IHC and immunocytochemistry/immunofluorescence (ICC/IF). Suitable for mouse samples.
- Cited in over 285 publications
- PBS only, removing anything extra from your antibodies, greater flexibility in assay design
- Affinity purified using Protein A
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Constituents: PBS
- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Mouse Lyve1 aa 1-250. The exact immunogen used to generate this antibody is proprietary information. Database link Q8BHC0
- Carrier free
- Yes
- Purification technique
- Affinity purification Protein A
- Concentration
- Purification notes
Protein-A Chromatography (+his tag depleted).
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Anti-LYVE1 antibody - BSA and Azide free (ab14917) is a rabbit polyclonal antibody provided in a carrier-free, conjugation ready format.
ab14917 is validated in ICC and IHC-P in mouse samples.
Carrier-free antibodies are compatible with our best-in-class range of Lightning-Link® conjugation kits.
Anti-LYVE1 antibody - BSA and Azide free (ab14917) specifically detects LYVE1 (UniProt ID: Q8BHC0; Molecular weight: 32kDa) and is sold in 100 ug selling sizes.
Quality and Validation
Antibody clone was first used in a scientific publication in 2006 and has been cited over 286 times in peer reviewed journals and is trusted by the scientific community.
Anti-LYVE1 antibody - BSA and Azide free (ab14917) has 34 independent reviews from customers.
Target Information
LYVE-1 (Lymphatic Vessel Endothelial Receptor 1) is primarily expressed on lymphatic endothelial cells and plays a crucial role in hyaluronan (HA) transport and turnover. It is also involved in lymphangiogenesis and immune responses, with altered LYVE-1 expression linked to various diseases, including cancer and inflammatory conditions. For instance, LYVE-1 expression is downregulated in human liver cancer and cirrhosis. Additionally, it is linked to intramuscular hemangioma and complete androgen insensitivity syndrome. Changes in LYVE-1 expression can impact lymphangiogenesis and immune responses, contributing to disease progression.
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Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The protein "LYVE1" also known as Lymphatic Vessel Endothelial Hyaluronan Receptor 1 has a molecular mass of about 60 kDa. This protein is located on the surface of lymphatic endothelial cells. Its expression occurs mainly within the lymphatic vessels serving as an important marker for identifying lymphatic endothelium. LYVE1 facilitates the transportation of hyaluronan an important glycosaminoglycan through lymphatic vessels playing a critical role in the maintenance of extracellular matrix and tissue fluid homeostasis.
- Biological function summary
LYVE1 plays a role in lymphatic system regulation and immune cell trafficking. It forms part of a network that binds hyaluronan contributing to the regulation of cell migration and adhesion. This protein interacts with molecules like CD44 and other receptors which also participate in hyaluronan binding. LYVE1's function in maintaining the balance of hyaluronan within tissues is central affecting not only the lymphatic system but also immune responses.
- Pathways
LYVE1 engages in both the hyaluronan metabolism and lymphangiogenesis pathways. Its interaction with CD44 plays a significant role in the transport and uptake of hyaluronan influencing cellular processes such as proliferation and motility. These interactions link LYVE1 to pathways controlling fluid balance and immune surveillance marking it as essential for maintaining healthy lymphatic and immune function.
- Associated diseases and disorders
LYVE1 shows a connection to lymphatic-related conditions such as lymphedema and cancer metastasis. Alterations or dysregulation of LYVE1 expression can affect lymphatic function potentially leading to the accumulation of interstitial fluid as seen in lymphedema. In cancer increased LYVE1 expression can relate to tumor metastasis where it functions alongside proteins like VEGFR-3 in promoting lymphatic vessel growth and facilitating cancer cell spread.
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Tested
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Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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6 product images
Immunocytochemistry - Anti-LYVE1 antibody - BSA and Azide free (ab14917)
Immunocytochemistry/immunofluorecent analysis of mouse colon tissue labelling LYVE-1 with ab14917 (red).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYVE1 antibody - BSA and Azide free (ab14917)
Immunohistochemical analysis of paraffin-embedded mouse intestine tissue staining LYVE-1 with ab14917. Positive staining is shown in the lymphatic endothelial cells (red).
Divan et al PLoS One. 2018 May 3;13(5):e0196893. doi: 10.1371/journal.pone.0196893. eCollection 2018. Fig S1. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYVE1 antibody - BSA and Azide free (ab14917)
At the time point of 75dpi spirochetes (Bb) were not observed in association with the lymphatic-like vessels (LYVE-1) that run parallel to the sagittal sinus (SS, arrow) of the dura mater.Dura samples were collected from transcardially perfused mice by craniotomy and post-fixed in 4% paraformaldehyde for 24h at 4°C. Samples were permeabilized in 0.1% Triton X-100, washed 3 times, and serum-blocked in 2.5% goat serum/PBS containing 1:100 dilution of Fc block. For B. burgdorferi staining, each sample was incubated in 1:100 dilution of rat anti-mouse unconjugated monoclonal anti-CD31 IgG, and 1:50 dilution biotinylated rabbit anti-B. burgdorferi polyclonal IgG at 4°C overnight. On the following day, the samples were washed, and stained with 1:100 dilution of Alexa 555 goat anti-rat polyclonal IgG, and 1:200 dilution of Alexa 488 streptavidin{"type":"entrez-protein","attrs":{"text":"S11223","term_id":"112468","term_text":"pir||S11223"}} for 1 hour at room temperature, covered from light. Secondary antibody-only controls for B. burgdorferi indirect fluorescent assay were performed in vitro and no fluorescence was observed.
Some of the dura samples were also stained for lymphatic vessels in a separate step, using 1:200 ab14917, followed by washing and secondary staining with 1:200 Alexa 633 goat-anti rabbit polyclonal IgG (yellow).
This image is courtesy of a customer review submitted by Elizabeth Chlipala on 18 November 2005.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYVE1 antibody - BSA and Azide free (ab14917)
ab14917 at a 1/100 dilution staining LYVE1 from mouse tuberculosis infected lung by immunohistochemistry (paraffin-embedded sections). The antibody was incubated with the tissue for 30 minutes and then detected with an HRP conjugated goat anti-rabbit antibody.
Image is courtesy of an anonymous customer reviewImmunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYVE1 antibody - BSA and Azide free (ab14917)
ab14917 staining LYVE1 in mouse uterus tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections).
Tissue was fixed with formaldehyde and blocked with 3% serum for 30 minutes at 20°C; antigen retrieval was by heat mediation in a EDTA-buffer pH 9.0. Samples were incubated with primary antibody (1/50 in PBS) for 12 hours at 20°C. A biotin-conjugated Goat anti-rabbit polyclonal (1/200) was used as the secondary antibody.
This image is courtesy of an anonymous customer reviewImmunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYVE1 antibody - BSA and Azide free (ab14917)
ab14917 at 1/2000 dilution staining Ha-Ras transgenic mouse bladder (cancer) by Immunohistochemistry (Formalin-fixed paraffin-embedded sections). The tissue was formaldehyde fixed and blocked with serum prior to incubation with the primary antibody for 12 hours. A biotinylated polyclonal antibody was used as the secondary.
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