AB139190

Anti-LZP antibody [EPR9348]

RabMAb
Recombinant
What is this?

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(2 Publications)

Rabbit Recombinant Monoclonal LZP antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications.

View Alternative Names

LZP, UNQ826/PRO1753, OIT3, Oncoprotein-induced transcript 3 protein, Liver-specific zona pellucida domain-containing protein

1 Images

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Western blot - Anti-LZP antibody [EPR9348] (AB139190)

All lanes:

Western blot - Anti-LZP antibody [EPR9348] (ab139190) at 1/1000 dilution

Lane 1:

Human fetal liver lysate at 10 µg

Lane 2:

Human plasma lysate at 10 µg

Secondary

All lanes:

Goat anti-rabbit HRP at 1/2000 dilution

Predicted band size: 60 kDa

false

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR9348

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

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Product details

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

Species reactivity
Rat: We have preliminary internal testing data to indicate this antibody may not react with this species.
Please contact us for more information.

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Properties and storage information

Form

Liquid

Purity

Tissue culture supernatant

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LZP also known as leucine zipper protein is a structural protein that plays a significant role in various cellular processes. It has a molecular mass of approximately 25 kDa. LZP is expressed highly in the liver and lungs with moderate expression observed in the brain and heart. The presence of the leucine zipper motif in LZP allows it to function as a transcription factor facilitating the regulation of gene expression through dimerization and DNA binding.

Biological function summary

LZP interacts with other proteins to regulate cell proliferation and differentiation. The protein forms part of a larger complex involved in these cellular processes. Through its action in transcription regulation LZP influences the expression of genes critical for cell cycle progression and apoptosis. During normal cellular function LZP maintains a balance between cell growth and programmed cell death contributing to tissue homeostasis.

Pathways

Research identifies LZP playing a role in the MAPK/ERK signaling pathway and the NF-κB signaling pathway. These pathways are essential for transmitting signals from the cell surface to the DNA in the nucleus impacting cell survival and differentiation. LZP interacts closely with proteins such as c-Jun and p53 within these pathways suggesting its importance in signal transduction and gene transcription.

LZP has connections to certain types of cancer including liver and lung cancer. Studies indicate that aberrant expression or mutations in LZP can lead to uncontrolled cell proliferation contributing to tumorigenesis. In addition LZP's interaction with the protein p53 known for its tumor-suppressing activities highlights its role in these diseases. Understanding LZP's functions and pathways offers potential targets for therapeutic intervention in related disorders.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

May be involved in hepatocellular function and development.

See full target information OIT3

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in cardiovascular medicine 9:981333 PubMed36818914

2023

Angiotensin receptor-neprilysin inhibitor improves coronary collateral perfusion.

Applications

Unspecified application

Species

Unspecified reactive species

Kangbo Li,Victoria Kratzmann,Mengjun Dai,Nora Gatzke,Petra Rocic,Peter Bramlage,Olaf Grisk,Lubomir T Lubomirov,Meike Hoffmeister,Martin A Lauxmann,Oliver Ritter,Eva Buschmann,Michael Bader,Anja Bondke Persson,Ivo Buschmann,Philipp Hillmeister

Cancer immunology, immunotherapy : CII 71:2677-2689 PubMed35353239

2022

OIT3 mediates macrophage polarization and facilitates hepatocellular carcinoma progression.

Applications

Unspecified application

Species

Unspecified reactive species

Shuai Yang,Jiangang Zhang,Yanquan Xu,Jingchun Wang,Huakan Zhao,Juan Lei,Yu Zhou,Yu Chen,Lei Wu,Mingyue Zhou,Lu Zheng,Xiaohui Ji,Yongsheng Li

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-LZP antibody [EPR9348]

Western blot - Anti-LZP antibody [EPR9348] (AB139190)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Product details

Properties and storage information

Form

Purity

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (2)

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