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AB127035

Anti-LZTS1/FEZ1 antibody

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(1 Publication)

Rabbit Polyclonal LZTS1/FEZ1 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human LZTS1 aa 300 to C-terminus.

View Alternative Names

FEZ1, LZTS1, Leucine zipper putative tumor suppressor 1, F37/esophageal cancer-related gene-coding leucine-zipper motif, Fez1

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LZTS1/FEZ1 antibody (AB127035)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LZTS1/FEZ1 antibody (AB127035)

ab127035, at 1/250 dilution, staining LZTS1/FEZ1 in paraffin embedded Human breast cancer tissue.

Western blot - Anti-LZTS1/FEZ1 antibody (AB127035)
  • WB

Unknown

Western blot - Anti-LZTS1/FEZ1 antibody (AB127035)

7.5% SDS PAGE

All lanes:

Western blot - Anti-LZTS1/FEZ1 antibody (ab127035) at 1/1000 dilution

All lanes:

U87-MG whole cell lysate at 30 µg

Predicted band size: 67 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human LZTS1 aa 300 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9Y250

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The LZTS1/FEZ1 also known simply as LZTS1 functions as a tumor suppressor protein. Its gene encodes a leucine zipper putative tumor suppressor 1. LZTS1 has a molecular weight of approximately 67 kDa. This protein localizes mostly in the cytoplasm of cells and shows a specific expression pattern in a range of tissues including the prostate brain and lung. Its presence is noticeable in certain developmental stages and specific types of cells suggesting an important regulatory role in cellular functions.
Biological function summary

LZTS1 plays a significant role in cell cycle regulation and the inhibition of tumorigenesis. It does not typically form part of a complex but associates closely with other proteins to exert its effect. LZTS1 negatively regulates cell proliferation by interacting with cyclin-dependent kinase 1 (Cdk1) resulting in the inhibition of cell cycle progression from the G1 to S phase. This activity showcases its importance as a protective mechanism against uncontrolled cell division and cancer development.

Pathways

LZTS1 integrates into important regulatory pathways specifically the cell cycle and apoptosis pathways. In the regulation of the cell cycle LZTS1 partners with proteins such as Cdk1 and is implicated in the careful orchestration of cell division. In the apoptotic pathway while LZTS1 itself may not directly induce apoptosis its influence on cell cycle arrest can indirectly promote apoptosis representing a link to protein interactions that involve p53-mediated pathways.

LZTS1 has a significant connection to various cancers including prostate cancer and lung cancer. The reduced expression or mutation of LZTS1 is often observed in these malignancies hinting at a loss of its tumor-suppressing capabilities. Additionally LZTS1 interacts with proteins like β-catenin in colorectal cancer indicating its involvement in the Wnt signaling pathway dysregulation seen in these disorders. The study of LZTS1's role in such diseases aids in the understanding and potential development of targeted cancer therapies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor.
See full target information LZTS1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of clinical investigation 134: PubMed39286971

2024

SARS-CoV-2 Delta and Omicron variants resist spike cleavage by human airway trypsin-like protease.

Applications

Unspecified application

Species

Unspecified reactive species

Wenyan Ren,Weiqi Hong,Jingyun Yang,Jun Zou,Li Chen,Yanan Zhou,Hong Lei,Aqu Alu,Haiying Que,Yanqiu Gong,Zhenfei Bi,Cai He,Minyang Fu,Dandan Peng,Yun Yang,Wenhai Yu,Cong Tang,Qing Huang,Mengli Yang,Bai Li,Jingmei Li,Junbin Wang,Xuelei Ma,Hongbo Hu,Wei Cheng,Haohao Dong,Jian Lei,Lu Chen,Xikun Zhou,Jiong Li,Wei Wang,Guangwen Lu,Guobo Shen,Li Yang,Jinliang Yang,Zhenling Wang,Guowen Jia,Zhaoming Su,Bin Shao,Hanpei Miao,Johnson Yiu-Nam Lau,Yuquan Wei,Kang Zhang,Lunzhi Dai,Shuaiyao Lu,Xiawei Wei
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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