Anti-LZTS1/FEZ1 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The LZTS1/FEZ1 also known simply as LZTS1 functions as a tumor suppressor protein. Its gene encodes a leucine zipper putative tumor suppressor 1. LZTS1 has a molecular weight of approximately 67 kDa. This protein localizes mostly in the cytoplasm of cells and shows a specific expression pattern in a range of tissues including the prostate brain and lung. Its presence is noticeable in certain developmental stages and specific types of cells suggesting an important regulatory role in cellular functions.

Biological function summary

LZTS1 plays a significant role in cell cycle regulation and the inhibition of tumorigenesis. It does not typically form part of a complex but associates closely with other proteins to exert its effect. LZTS1 negatively regulates cell proliferation by interacting with cyclin-dependent kinase 1 (Cdk1) resulting in the inhibition of cell cycle progression from the G1 to S phase. This activity showcases its importance as a protective mechanism against uncontrolled cell division and cancer development.

Pathways

LZTS1 integrates into important regulatory pathways specifically the cell cycle and apoptosis pathways. In the regulation of the cell cycle LZTS1 partners with proteins such as Cdk1 and is implicated in the careful orchestration of cell division. In the apoptotic pathway while LZTS1 itself may not directly induce apoptosis its influence on cell cycle arrest can indirectly promote apoptosis representing a link to protein interactions that involve p53-mediated pathways.

Associated diseases and disorders

LZTS1 has a significant connection to various cancers including prostate cancer and lung cancer. The reduced expression or mutation of LZTS1 is often observed in these malignancies hinting at a loss of its tumor-suppressing capabilities. Additionally LZTS1 interacts with proteins like β-catenin in colorectal cancer indicating its involvement in the Wnt signaling pathway dysregulation seen in these disorders. The study of LZTS1's role in such diseases aids in the understanding and potential development of targeted cancer therapies.