Anti-M13 + Fd Bacteriophage Coat Proteins antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

M13 phage coat proteins are essential in the assembly and secretion process of the bacteriophage. These proteins form a cylindrical structure encasing the single-stranded DNA core critical for the infection cycle of the virus. During M13 phage display technique scientists exploit these coat proteins to present foreign proteins or peptides on the surface. This capability allows these phage particles to function as tools for molecular library screening and antibody engineering. Although not part of a traditional multiprotein complex they work coordinately to maintain phage integrity and facilitate propagation.

Pathways

M13 phage coat proteins are integral to the phage assembly and secretion pathways. These pathways occur in the bacterial host and ensure the correct encapsulation of the single-stranded DNA genome. Related proteins in these processes include bacterial proteins that participate in host cell machinery like the Tol and Pal system which interact with coat proteins like pIII during the phage infection cycle. These interactions are fundamental for the phage's continued life cycle and its use in biotechnological applications like phage ELISA.