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AB234740

Anti-MA2 antibody

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(1 Publication)

Rabbit Polyclonal MA2 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PNMA2 aa 1 to C-terminus.

View Alternative Names

KIAA0883, MA2, PNMA2, Paraneoplastic antigen Ma2, 40 kDa neuronal protein, Onconeuronal antigen Ma2, Paraneoplastic neuronal antigen MM2

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MA2 antibody (AB234740)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MA2 antibody (AB234740)

Paraffin-embedded human brain tissue stained for MA2 with ab234740 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human PNMA2 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9UL42

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Cynomolgus monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Orangutan": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MA2 also known as PNMA2 (Paraneoplastic Ma antigen 2) is a protein with a mass of approximately 57 kDa. It is primarily expressed in brain tissues and shows significant expression in neurons. The precise mechanism of action for MA2 involves its role in cellular processes that are yet to be fully detailed but its expression pattern hints at an importance in neuronal function. Furthermore due to its expression MA2 serves as an important target for researching neuronal diseases and autoimmune responses.
Biological function summary

MA2 plays an important role in the nervous system. It is part of a complex known as neuron-specific RNA-binding proteins which are critical for the regulation of mRNA transport and translation in neurons. MA2 interacts directly with other proteins within this complex to enable proper neural function affecting synaptic plasticity and neuron survival. This involvement suggests that MA2 has functions critical to maintaining normal neurological activity.

Pathways

The protein MA2 interacts with important signaling networks such as the MAPK/ERK pathway and PI3K/AKT pathway. These pathways are essential for neurodevelopment cell survival and synaptic functions. MA2's interaction with proteins like ERK1/2 and AKT suggests it plays a role in the modulation of these pathways impacting cellular communication and the overall neuronal response to external stimuli.

MA2 is associated with conditions such as paraneoplastic neurological syndromes and certain types of cancer. Anti-MA2 antibodies are frequently found in patients with paraneoplastic limbic encephalitis a condition where the immune system mistakenly attacks the brain tissue. Proteins like HuD also connect to MA2 through these neurological disorders as they share similar immune target profiles in affected individuals reflecting autoimmune responses contributing to disease pathology.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information PNMA2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in cellular neuroscience 15:662035 PubMed34025359

2021

Integrative Cell Type-Specific Multi-Omics Approaches Reveal Impaired Programs of Glial Cell Differentiation in Mouse Culture Models of DM1.

Applications

Unspecified application

Species

Unspecified reactive species

Anchel González-Barriga,Louison Lallemant,Diana M Dincã,Sandra O Braz,Hélène Polvèche,Paul Magneron,Cédric Pionneau,Aline Huguet-Lachon,Jean-Baptiste Claude,Cerina Chhuon,Ida Chiara Guerrera,Cyril F Bourgeois,Didier Auboeuf,Geneviève Gourdon,Mário Gomes-Pereira
View all publications
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