Anti-MAB21L1 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The MAB21L1 gene encodes for a protein known as "mab-21-like 1" sometimes referred to as CORD6. MAB21L1 is a protein with a molecular mass of approximately 42 kDa. It exhibits expression in various tissues but it is highly observed in developing brain and neural tissues during embryogenesis. The presence of this protein in specific areas signals its relevance to the neurological development process. In cellular components MAB21L1 shows a pattern that indicates its involvement in the regulation of transcription as part of its mechanical function.

Biological function summary

The protein participates in critical roles in cell differentiation during embryonic development. MAB21L1 forms part of a protein complex suggesting interactions with various molecular partners that enhance its functional capacity. It is implicated in the proper formation and growth of ocular tissues and other neurological structures. The protein thereby supports the development of complex neuronal networks which are necessary for functional adult brain architecture.

Pathways

Literature describes MAB21L1 as instrumental within pathways associated with neural development and vision. Specifically it is involved in the retinoic acid signaling pathway known for regulating gene expression during morphogenesis. MAB21L1 also interacts with transforming growth factor-beta (TGF-beta) signaling often connected with protein SMAD4 a regulator of gene expression related to cellular processes such as growth and differentiation. In these pathways MAB21L1 helps coordinate the cellular responses essential for developmental processes.

Associated diseases and disorders

MAB21L1 associates with congenital disorders affecting vision and brain development. Mutations or disruptions in its gene can lead to a condition known as coloboma characterized by defects in the eye structure. Additionally some research links abnormalities in MAB21L1 function to neurodevelopmental disorders. Within these contexts MAB21L1 interacts with proteins like PAX6 important for eye and CNS formation. These associations suggest that maintaining MAB21L1 activity within normal physiological limits is very important for preventing developmental anomalies.