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AB154311

Anti-MAB21L1 antibody

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(2 Publications)

Rabbit Polyclonal MAB21L1 antibody. Suitable for WB and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MAB21L1 aa 150 to C-terminus.

View Alternative Names

CAGR1, Nbla00126, MAB21L1, Putative nucleotidyltransferase MAB21L1, Protein mab-21-like 1

2 Images
Western blot - Anti-MAB21L1 antibody (AB154311)
  • WB

Unknown

Western blot - Anti-MAB21L1 antibody (AB154311)

10% SDS PAGE

All lanes:

Western blot - Anti-MAB21L1 antibody (ab154311) at 1/1000 dilution

All lanes:

NT2D1 whole cell lysate at 30 µg

Predicted band size: 41 kDa

false

Western blot - Anti-MAB21L1 antibody (AB154311)
  • WB

Unknown

Western blot - Anti-MAB21L1 antibody (AB154311)

10% SDS PAGE

All lanes:

Western blot - Anti-MAB21L1 antibody (ab154311) at 1/1000 dilution

All lanes:

NIH 3T3 whole cell lysate at 30 µg

Predicted band size: 41 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human MAB21L1 aa 150 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q13394

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  • 4
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Chicken": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Xenopus laevis": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Xenopus tropicalis": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Zebrafish": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The MAB21L1 gene encodes for a protein known as "mab-21-like 1" sometimes referred to as CORD6. MAB21L1 is a protein with a molecular mass of approximately 42 kDa. It exhibits expression in various tissues but it is highly observed in developing brain and neural tissues during embryogenesis. The presence of this protein in specific areas signals its relevance to the neurological development process. In cellular components MAB21L1 shows a pattern that indicates its involvement in the regulation of transcription as part of its mechanical function.
Biological function summary

The protein participates in critical roles in cell differentiation during embryonic development. MAB21L1 forms part of a protein complex suggesting interactions with various molecular partners that enhance its functional capacity. It is implicated in the proper formation and growth of ocular tissues and other neurological structures. The protein thereby supports the development of complex neuronal networks which are necessary for functional adult brain architecture.

Pathways

Literature describes MAB21L1 as instrumental within pathways associated with neural development and vision. Specifically it is involved in the retinoic acid signaling pathway known for regulating gene expression during morphogenesis. MAB21L1 also interacts with transforming growth factor-beta (TGF-beta) signaling often connected with protein SMAD4 a regulator of gene expression related to cellular processes such as growth and differentiation. In these pathways MAB21L1 helps coordinate the cellular responses essential for developmental processes.

MAB21L1 associates with congenital disorders affecting vision and brain development. Mutations or disruptions in its gene can lead to a condition known as coloboma characterized by defects in the eye structure. Additionally some research links abnormalities in MAB21L1 function to neurodevelopmental disorders. Within these contexts MAB21L1 interacts with proteins like PAX6 important for eye and CNS formation. These associations suggest that maintaining MAB21L1 activity within normal physiological limits is very important for preventing developmental anomalies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Putative nucleotidyltransferase required for several aspects of embryonic development including normal development of the eye (PubMed : 27103078, PubMed : 30487245). It is unclear whether it displays nucleotidyltransferase activity in vivo (PubMed : 27271801). Binds single-stranded RNA (ssRNA) (PubMed : 27271801).
See full target information MAB21L1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Experimental and therapeutic medicine 26:473 PubMed37753299

2023

Effects and mechanism of Rictor interference in podocyte injury induced by high glucose.

Applications

Unspecified application

Species

Unspecified reactive species

Yan Zeng,Changbin Xiong,Yinxiang Chen,Chunyun Yang,Qiuyue Li

Aging 14:6128-6148 PubMed35951367

2022

MAB21L1 promotes survival of lens epithelial cells through control of αB-crystallin and ATR/CHK1/p53 pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Yuan Xiao,Jia-Wen Xiang,Qian Gao,Yue-Yue Bai,Zhao-Xia Huang,Xiao-Hui Hu,Ling Wang,David Wan-Cheng Li
View all publications
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Product promise

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