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AB223710

Anti-MACC1 antibody

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(1 Publication)

Rabbit Polyclonal MACC1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MACC1 aa 1-100.

View Alternative Names

Metastasis-associated in colon cancer protein 1, SH3 domain-containing protein 7a5, MACC1

4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MACC1 antibody (AB223710)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MACC1 antibody (AB223710)

Paraffin embedded sections of human kidney were stained for MACC1 with ab223710 at 1/50 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MACC1 antibody (AB223710)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MACC1 antibody (AB223710)

Paraffin embedded sections of human stomach cancer were stained for MACC1 with ab223710 at 1/50 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MACC1 antibody (AB223710)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MACC1 antibody (AB223710)

Paraffin embedded sections of human colon were stained for MACC1 with ab223710 at 1/50 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MACC1 antibody (AB223710)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MACC1 antibody (AB223710)

Paraffin embedded sections of human colorectal cancer were stained for MACC1 with ab223710 at 1/50 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human MACC1 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

Q6ZN28

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Orangutan": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MACC1 known as Metastasis-Associated in Colon Cancer 1 plays an important mechanical role in the regulation of cell proliferation and mobility. It has a molecular mass of approximately 82 kDa. This protein expresses prominently in the colon and other epithelial tissues where it assists processes linked to cancer progression. Researchers acknowledge its involvement in cellular signaling making it a focus of biomedical studies.
Biological function summary

MACC1 affects tumor growth and metastasis through its role as a regulator of the HGF/MET signaling pathway. It influences gene expression that promotes invasive behavior in cancer cells. MACC1 does not form a larger complex with other proteins in its function but coordinates with several signaling molecules to control gene transcription linked to metastasis. This ability highlights its significance in oncological contexts.

Pathways

MACC1 protein heavily interacts with the HGF/MET pathway which is central to cell growth movement and survival. MACC1 boosts MET expression and pathway activation thereby amplifying signals for cell invasion. It also ties to the Wnt signaling pathway and influences processes related to cell adhesion and metastasis. Through these pathways MACC1 contributes to signaling cascades that enhance cellular capabilities critical to tumor development.

MACC1 is closely tied to colorectal cancer where it predicts aggressive tumor behavior and patient prognosis. Gastric cancer also witnesses MACC1's influence where it serves similar roles in tumor progression. Through its interaction with the MET protein MACC1 exacerbates disease states by promoting invasion and resistance. This connection between MACC1 and specific tumors renders it a potential target for therapeutic interventions specific to these cancers.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo.
See full target information MACC1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of clinical investigation 133: PubMed36928117

2023

Keratinocytes sense and eliminate CRISPR DNA through STING/IFN-κ activation and APOBEC3G induction.

Applications

Unspecified application

Species

Unspecified reactive species

Mrinal K Sarkar,Ranjitha Uppala,Chang Zeng,Allison C Billi,Lam C Tsoi,Austin Kidder,Xianying Xing,Bethany E Perez White,Shuai Shao,Olesya Plazyo,Sirisha Sirobhushanam,Enze Xing,Yanyun Jiang,Katherine A Gallagher,John J Voorhees,J Michelle Kahlenberg,Johann E Gudjonsson
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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