Anti-MAEA antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

MAEA also known as Macrophage Erythroblast Attacher is a protein with a mass of approximately 42 kDa. This protein functions mechanically by anchoring mature erythroblasts to macrophages in the erythroblastic islands of the bone marrow. You can find MAEA expression in hematopoietic organs such as the spleen bone marrow and lymph nodes. Its expression is not limited to these sites since several tissues exhibit lower levels of expression indicating a broader biological role.

Biological function summary

MAEA plays a significant role in hematopoiesis by facilitating communication between macrophages and erythroblasts. It forms part of a protein complex that ensures the stability and viability of developing erythrocytes. This protein interaction is critical for the normal maturation of red blood cells helping to maintain the balance and production of these cells under varying physiological conditions.

Pathways

MAEA participates in the erythrophagocytosis and erythroblast enucleation processes. MAEA contributes to the interaction with proteins such as ICAM-4 and VLA-4 which are important in these pathways. Through these interactions MAEA is instrumental in effectively mediating red blood cell clearance and differentiation ensuring the proper function of erythroblastic islands within the bone marrow niche.

Associated diseases and disorders

MAEA links to pathologies such as anemia and myeloproliferative disorders. Altered MAEA expression or function can disturb normal erythropoiesis leading to ineffective red blood cell production and anemia. Additionally its interaction with proteins like ICAM-4 can affect disease progression and severity. Researchers continue to study these connections to understand MAEA’s role in hematological disorders better.