AB193330

Anti-MAGEA1 antibody [MA454]

Be the first to review this product! Submit a review

|

(2 Publications)

Mouse Monoclonal MAGEA1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human MAGEA1.

View Alternative Names

MAGE1, MAGE1A, MAGEA1, Melanoma-associated antigen 1, Antigen MZ2-E, Cancer/testis antigen 1.1, MAGE-1 antigen, CT1.1

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MAGEA1 antibody [MA454] (AB193330)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MAGEA1 antibody [MA454] (AB193330)

Immunohistochemical analysis of formalin fixed paraffin embedded human testis labeling MAGEA1 with ab193330 at 0.5 μg/ml

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

MA454

Isotype

IgG1

Light chain type

kappa

Carrier free

No

Reacts with

Human

Applications

IHC-P

Immunogen

Recombinant Full Length Protein corresponding to Human MAGEA1.

Specificity

ab193330 does not cross-react with MAGE-2, -3, -4, -6 -9, -10, -or -12 proteins.

style

left-column

Alternative Products

Primary Antibodies

AB25834

Anti-MAGEA1 antibody [SPM282]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MAGEA1 antibody [SPM282] (AB25834)

0
0

Primary Antibodies

AB183309

Anti-MAGEA1 antibody [SP194] - C-terminal

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MAGEA1 antibody [SP194] - C-terminal (AB183309)

0
0

Primary Antibodies

AB227664

Anti-MAGEA1 antibody [SP188]

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MAGEA1 antibody [SP188] (AB227664)

0
0

Primary Antibodies

AB16031

Anti-MAGEA1 antibody

Immunocytochemistry/ Immunofluorescence - Anti-MAGEA1 antibody (AB16031)

0
0

Primary Antibodies

AB245755

Anti-MAGEA1 antibody [SP194] - BSA and Azide free

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MAGEA1 antibody [SP194] - BSA and Azide free (AB245755)

0
0

Primary Antibodies

AB243935

Anti-MAGEA1 antibody [SP188] - BSA and Azide free

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MAGEA1 antibody [SP188] - BSA and Azide free (AB243935)

0
0

Complementary Products

Primary Antibodies

AB223498

Anti-CTAG1B antibody [SP349]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CTAG1B antibody [SP349] (AB223498)

0
0

Primary Antibodies

AB219650

Anti-PRAME antibody [EPR20330]

BOND RX™ Validated|RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PRAME antibody [EPR20330] (AB219650)

0
0

Primary Antibodies

AB97672

Anti-SCP3 antibody [Cor 10G11/7]

BOND RX™ Validated|Recombinant

Immunohistochemistry (Frozen sections) - Anti-SCP3 antibody [Cor 10G11/7] (AB97672)

5
10

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

5
20

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1-2 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol." } } }

style

left-column

style

left-column

Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A/G

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

style

left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MAGEA1 also known as MAGE-1 is a member of the MAGE (Melanoma Antigen Gene) family of proteins. It has a molecular weight of approximately 39 kDa. MAGEA1 is expressed mainly in male germline tissues and in various cancer cells but not in adult somatic tissues. The protein functions mechanically by interacting with specific molecules in cells although detailed mechanisms are still under investigation.

Biological function summary

The protein encoded by MAGEA1 participates in cellular processes linked to cancer development and progression. It does not function as part of a larger complex but interacts directly with certain cellular pathways. In particular the expression of MAGEA1 is often associated with transformation events and uncontrolled cell proliferation underlining its role in oncogenesis.

Pathways

MAGEA1 plays roles in oncogenic and apoptotic pathways. It can influence the p53 signaling pathway important for cell cycle regulation and apoptosis. The interaction with other proteins such as p53 and potentially with the NF-kB pathway highlights how MAGEA1 might modulate the apoptotic response. MAGEA1 impacts cellular mechanisms by affecting apoptosis and proliferation through these pathways.

MAGEA1 is strongly related to cancer particularly melanoma and some other tumor types. Its expression in cancers makes MAGEA1 a target for cancer immunotherapy. MAGEA1 associates with proteins like p53 in certain cancers and can alter the tumor suppressive characteristics. Its role in these diseases presents MAGEA1 as a biomarker for cancer diagnosis and treatment adding clinical significance to its study.

style

left-column

style

left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

Target data

May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.

See full target information MAGEA1

style

left-column

Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Genetics and molecular biology 45:e20210067 PubMed35167648

2022

MT1G inhibits the growth and epithelial-mesenchymal transition of gastric cancer cells by regulating the PI3K/AKT signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Guofeng Xu,Linfeng Fan,Shufeng Zhao,Canhui OuYang

Journal of hematology & oncology 12:106 PubMed31640756

2019

MAGE-A1 in lung adenocarcinoma as a promising target of chimeric antigen receptor T cells.

Applications

Unspecified application

Species

Unspecified reactive species

Yuan Mao,Weifei Fan,Hao Hu,Louqian Zhang,Jerod Michel,Yaqin Wu,Jun Wang,Lizhou Jia,Xiaojun Tang,Li Xu,Yan Chen,Jin Zhu,Zhenqing Feng,Lin Xu,Rong Yin,Qi Tang

View all publications

style

left-column

style

left-column

style

right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com