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AB96236

Anti-MAGEA11 antibody

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(3 Publications)

Rabbit Polyclonal MAGEA11 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human MAGEA11 aa 50 to C-terminus.

View Alternative Names

MAGE11, MAGEA11, Melanoma-associated antigen 11, Cancer/testis antigen 1.11, MAGE-11 antigen, CT1.11

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-MAGEA11 antibody (AB96236)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-MAGEA11 antibody (AB96236)

Immunofluorescence analysis of paraformaldehyde-fixed A431, using ab96236 at 1/500 dilution. (1) ab96236, (2)Merged with DNA probe.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MAGEA11 antibody (AB96236)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MAGEA11 antibody (AB96236)

Immunohistochemical analysis of paraffin-embedded Ca922 xenograft, using ab96236 at 1/500 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P, ICC/IF

applications

Immunogen

Synthetic Peptide within Human MAGEA11 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P43364

Specificity

It is likely that the antibody will cross-react with other proteins of the MAGE family. This information is based on BLAST homology and has not been verified experimentally. Please contact our Scientific Support for further information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/200", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MAGEA11 also known as Melanoma Antigen Family A11 is involved in the regulation of androgen receptor activity. This protein has a mass of approximately 38 kDa. It is mainly expressed in various cancerous tissues and certain normal tissues such as the testis. MAGEA11 functions by interacting with androgen receptors and modulating their transcriptional activity which plays a significant role in cellular growth and differentiation especially in hormone-sensitive cells.
Biological function summary

MAGEA11 modulates androgen receptor signaling pathways. It does not form part of a complex but actively participates in the enhancement of the receptor's transcriptional activity. This activity affects cell proliferation and can influence cancer progression. MAGEA11 expression in normal tissues remains limited implying its role is mostly in disease states or specific developmental stages.

Pathways

MAGEA11 has a significant role in the androgen receptor signaling pathway and cellular response pathways to hormonal stimuli. It enhances the interaction between androgen receptors and other co-regulators such as AR-associated proteins. By modulating this pathway MAGEA11 interacts with proteins like p300 which is involved in the transcription regulation by histone acetylation thereby influencing gene expression linked to growth and development.

MAGEA11 has a connection with prostate cancer and certain melanoma forms. In prostate cancer MAGEA11's overexpression leads to heightened androgen receptor activity promoting disease progression. The protein interacts with p300 in these conditions affecting gene transcription associated with cancer cell proliferation. Understanding these interactions aids in decoding the molecular mechanisms of hormone-related cancers offering potential therapeutic targets.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Acts as androgen receptor coregulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumor progression.
See full target information MAGEA11
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Histochemistry and cell biology 163:84 PubMed40875056

2025

Extracellular matrix reorganization during endometrial decidualization.

Applications

Unspecified application

Species

Unspecified reactive species

Mona Gebril,Sparhawk Mulder,Rimi Das,Shanmugasundaram Nallasamy

Discover oncology 16:88 PubMed39864021

2025

A panel of cancer testis antigens in squamous cell carcinoma of the lung, head and neck, and esophagus: implication for biomarkers and therapeutic targets.

Applications

Unspecified application

Species

Unspecified reactive species

Lin Li,Xin Zhang,Jiayao Yan,Jingyi Guo,Fangcen Liu,Xiao Wei,Qin Liu,Kongcheng Wang,Baorui Liu

Frontiers in genetics 14:1118889 PubMed37124627

2023

Unveiling DNA damage repair-based molecular subtypes, tumor microenvironment and pharmacogenomic landscape in gastric cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Weiqi Kong,Zhiqiang Wang,Bingyi Wang
View all publications
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Product promise

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