AB221559

Anti-MAGEB2 antibody

Name: Anti-MAGEB2 antibody (ab221559) | Abcam
Brand: Abcam Limited
SKU: AB221559

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(1 Publication)

Rabbit Polyclonal MAGEB2 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MAGEB2 aa 150-200.

View Alternative Names

Melanoma-associated antigen B2, Cancer/testis antigen 3.2, DSS-AHC critical interval MAGE superfamily 6, MAGE XP-2 antigen, MAGE-B2 antigen, CT3.2, DAM6, MAGEB2

1 Images

Immunocytochemistry/ Immunofluorescence - Anti-MAGEB2 antibody (AB221559)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-MAGEB2 antibody (AB221559)

Immunofluorescent analysis of PFA-fixed, Triton X-100 permeabilized U-2 OS cells labeling MAGEB2 with ab221559 at 4 μg/mL (green).

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human MAGEB2 aa 150-200. The exact immunogen used to generate this antibody is proprietary information.

O15479

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MAGEB2 or Melanoma Antigen Family B2 is part of the MAGEB family of proteins. It is a protein of about 32 kDa often known for its role in immunity and cancer biology. MAGEB2 expresses mainly in brain tissue and some cancers. Its presence in cancer types like melanoma makes it a significant subject for studies exploring tumor antigens and potential therapeutic targets.

Biological function summary

This protein involves itself in complex molecular interactions. MAGEB2 does not function alone; it associates with other proteins to regulate cellular processes such as apoptosis and cell cycle control. Its expression in specific tissues suggests roles in tissue-specific functions that are still the subject of research.

Pathways

Studies show MAGEB2 interacting within the p53 signaling pathway. It also connects with proteins like p53 and p73 which are well-known for their roles in these pathways. Through such interactions MAGEB2 can participate in cellular stress responses influencing the survival or death of cells undergoing stress.

Researchers link MAGEB2 to cancer especially melanoma and lung cancer. MAGEB2 serves as a tumor-associated antigen that can initiate immune responses against cancer cells. It shows connections to the MAGEA family proteins which also associate with cancer providing potential biomarkers for diagnosis or targets for immunotherapy.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3 : substrate complex.

See full target information MAGEB2

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Translational oncology 26:101562 PubMed36228410

2022

ARNTL2 is an indicator of poor prognosis, promotes epithelial-to-mesenchymal transition and inhibits ferroptosis in lung adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Huan Zhang,Guangyao Shan,Xing Jin,Xiangyang Yu,GuoShu Bi,Mingxiang Feng,Hao Wang,Miao Lin,Cheng Zhan,Qun Wang,Ming Li

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-MAGEB2 antibody

Immunocytochemistry/ Immunofluorescence - Anti-MAGEB2 antibody (AB221559)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

Complementary Products

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Product promise