Rabbit Polyclonal MAGEB2 antibody. Suitable for ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human MAGEB2 aa 150-200.
Images
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human MAGEB2 aa 150-200. The exact immunogen used to generate this antibody is proprietary information. Database link O15479
Reactivity data
Select an application| ICC/IF | |
|---|---|
| Human | Tested |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 0.25000-2.00000 µg/mL | Notes Fixation/Permeabilization: PFA/Triton X-100. |
Target data
Function
May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.
Alternative names
Melanoma-associated antigen B2, Cancer/testis antigen 3.2, DSS-AHC critical interval MAGE superfamily 6, MAGE XP-2 antigen, MAGE-B2 antigen, CT3.2, DAM6, MAGEB2
Recommended products
Rabbit Polyclonal MAGEB2 antibody. Suitable for ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human MAGEB2 aa 150-200.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human MAGEB2 aa 150-200. The exact immunogen used to generate this antibody is proprietary information. Database link O15479
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
MAGEB2 or Melanoma Antigen Family B2 is part of the MAGEB family of proteins. It is a protein of about 32 kDa often known for its role in immunity and cancer biology. MAGEB2 expresses mainly in brain tissue and some cancers. Its presence in cancer types like melanoma makes it a significant subject for studies exploring tumor antigens and potential therapeutic targets.
- Biological function summary
This protein involves itself in complex molecular interactions. MAGEB2 does not function alone; it associates with other proteins to regulate cellular processes such as apoptosis and cell cycle control. Its expression in specific tissues suggests roles in tissue-specific functions that are still the subject of research.
- Pathways
Studies show MAGEB2 interacting within the p53 signaling pathway. It also connects with proteins like p53 and p73 which are well-known for their roles in these pathways. Through such interactions MAGEB2 can participate in cellular stress responses influencing the survival or death of cells undergoing stress.
- Associated diseases and disorders
Researchers link MAGEB2 to cancer especially melanoma and lung cancer. MAGEB2 serves as a tumor-associated antigen that can initiate immune responses against cancer cells. It shows connections to the MAGEA family proteins which also associate with cancer providing potential biomarkers for diagnosis or targets for immunotherapy.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Immunocytochemistry/ Immunofluorescence - Anti-MAGEB2 antibody (ab221559)
Immunofluorescent analysis of PFA-fixed, Triton X-100 permeabilized U-2 OS cells labeling MAGEB2 with ab221559 at 4 μg/mL (green).
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