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AB104627

Anti-MAGED1/NRAGE antibody

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(1 Publication)

Rabbit Polyclonal MAGED1/NRAGE antibody. Suitable for WB and reacts with Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Mouse Maged1 aa 650-700 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

Nrage, Melanoma-associated antigen D1, Dlxin-1, MAGE-D1 antigen, Neurotrophin receptor-interacting MAGE homolog

1 Images
Western blot - Anti-MAGED1/NRAGE antibody (AB104627)
  • WB

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Western blot - Anti-MAGED1/NRAGE antibody (AB104627)

All lanes:

Western blot - Anti-MAGED1/NRAGE antibody (ab104627) at 1/500 dilution

Lane 1:

PC12 cell extracts with MAGED1 blocking peptide

Lane 2:

PC12 cell extracts

Predicted band size: 86 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat

Applications

WB

applications

Immunogen

Synthetic Peptide within Mouse Maged1 aa 650-700 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q9QYH6

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Stable for 12 months at -20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MAGED1 also known as NRAGE is a protein with diverse roles in cellular processes. It is a type of MAGE (Melanoma Antigen Gene) family member and its molecular weight is approximately 88 kDa. You find MAGED1 expressed in multiple tissues including the brain and testes where it plays various regulatory roles. This protein associates with other key molecules modulating different signaling events within the cell.
Biological function summary

MAGED1 influences neuronal development by interacting with various cellular components. It acts as a modulator in the NGF (nerve growth factor) and p75 neurotrophin receptor signaling pathways forming a complex with these receptors to manage neuronal apoptosis and differentiation. Its function ensures the appropriate response of neurons to growth signals closely monitoring neuronal growth and survival.

Pathways

MAGED1 is involved in the regulation of apoptosis and neuronal growth signaling. In the apoptosis pathway it partners with p75NTR enhancing the pathway’s pro-apoptotic signals. In neuronal growth signaling it interacts with TrkA and other neurotrophin receptors facilitating the accurate transmission of growth signals. Through these interactions MAGED1 plays a balancing act between promoting cell survival and inducing apoptosis depending on cellular context.

Researchers link MAGED1 to neurodegenerative conditions and cancer. Its involvement in apoptosis and neuronal regulation associates it with Alzheimer’s disease with alterations in MAGED1 expression impacting neuronal cells. Additionally in cancer the imbalance in MAGED1 regulation contributes to tumorigenesis. Its association with proteins like p75NTR and TrkA highlights its role in disease pathways suggesting it potentially serves as a therapeutic target.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3 : substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA coregulator, modulating the expression of core clock genes such as BMAL1 and NFIL3, induced, or NR1D1, repressed.
See full target information Maged1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Metabolites 12: PubMed35448530

2022

Metabolites and Biomarker Compounds of Neurodegenerative Diseases in Cerebrospinal Fluid.

Applications

Unspecified application

Species

Unspecified reactive species

Keiji Wakamatsu,Yoichi Chiba,Ryuta Murakami,Yumi Miyai,Koichi Matsumoto,Masaki Kamada,Wakako Nonaka,Naoya Uemura,Ken Yanase,Masaki Ueno
View all publications
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