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AB225687

Anti-Major pollen allergen Bet v 1-A protein antibody

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Rabbit Polyclonal Major pollen allergen Bet v 1-A protein antibody. Suitable for WB and reacts with Recombinant full length protein - Silver birch samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Silver birch BETVIA.

View Alternative Names

BETVI, BETVIA, Major pollen allergen Bet v 1-A, Allergen Bet v I-A

1 Images
Western blot - Anti-Major pollen allergen Bet v 1-A protein antibody (AB225687)
  • WB

Supplier Data

Western blot - Anti-Major pollen allergen Bet v 1-A protein antibody (AB225687)

This antibody has only been tested in WB using the recombinant protein, we have no data for endogenous protein.

All lanes:

Western blot - Anti-Major pollen allergen Bet v 1-A protein antibody (ab225687) at 1/500 dilution

Lane 1:

Recombinant Betula pendula Major pollen allergen Bet v 1-A protein, 100 ng

Lane 2:

Recombinant Betula pendula Major pollen allergen Bet v 1-A protein, 50 ng

Lane 3:

Recombinant Betula pendula Major pollen allergen Bet v 1-A protein, 25 ng

Lane 4:

Recombinant Betula pendula Major pollen allergen Bet v 1-A protein, 12.5 ng

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/50000 dilution

Predicted band size: 34 kDa

Observed band size: 34 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Silver birch

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Silver birch BETVIA.

P15494

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Recombinant full length protein - Silver birch": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p>This antibody has only been tested in WB using the recombinant protein, we have no data for endogenous protein.</p>" }, "Silver birch": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The major pollen allergen Bet v 1-A protein often referred to simply as Bet v 1 acts as an important component in allergic reactions to birch pollen. This protein with a molecular weight of approximately 17 kDa is primarily expressed in the pollen of birch trees. Bet v 1 is part of the pathogenesis-related protein family which sees significant expression during pollen formation. Researchers often study this allergen because of its central role in causing Type I hypersensitivity reactions in sensitive individuals.
Biological function summary

The function of Bet v 1 extends beyond simple pollen dispersion. This allergen binds to a variety of ligands including lipids and cytokinins and acts as a carrier for molecules within the pollen grain. Bet v 1 is not part of any complex; however its structure and binding capabilities have been analyzed extensively to understand its allergenic nature. This protein’s ability to interact with immune cells makes it a focus in allergenic studies helping to trigger the immune response upon contact with the mucosal lining of the respiratory tract.

Pathways

Bet v 1 plays a role in initiating immune pathways when it interacts with the human immune system. One important pathway is the IgE-mediated allergic pathway where Bet v 1 binds to IgE antibodies on the surface of mast cells and basophils. This interaction leads to the release of histamines and other inflammatory mediators. Bet v 1 is related to other pathogenesis-related proteins that also serve as allergens for example homologous proteins in different plant species like Mal d 1 from apple that share similar IgE-binding epitopes.

Bet v 1 is closely associated with birch pollen allergy a common cause of seasonal allergic rhinitis and asthma. Individuals with this allergy often suffer from symptoms such as sneezing runny nose and conjunctivitis during the birch pollen season. Bet v 1 is connected to cross-reactivity disorders particularly oral allergy syndrome which links birch pollen sensitivity to reactions with certain fruits like apples. This immunological cross-reactivity arises due to structural similarities between Bet v 1 and other related allergens.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May be a general steroid carrier protein.
See full target information BETVIA
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