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AB199104

Anti-mAKAP antibody

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(1 Publication)

Rabbit Polyclonal mAKAP antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human AKAP6.

View Alternative Names

AKAP100, KIAA0311, AKAP6, A-kinase anchor protein 6, AKAP-6, A-kinase anchor protein 100 kDa, Protein kinase A-anchoring protein 6, mAKAP, AKAP 100, PRKA6

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-mAKAP antibody (AB199104)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-mAKAP antibody (AB199104)

Immunohistochemical analysis of paraffin-embedded human thyroid cancer tissue sections labeling mAKAP with ab199104 at a 1/30 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human AKAP6. The exact immunogen used to generate this antibody is proprietary information.

Q13023

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/30 - 1/200", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MAKAP also known as muscle A-kinase anchoring protein plays an important role in cellular signaling by anchoring protein kinase A (PKA) and other signaling proteins. It has a molecular weight of approximately 250 kDa. mAKAP is primarily expressed in striated muscle tissues including cardiac and skeletal muscles. Its localization within the cell is important for its function as it coordinates the activity of various signaling molecules in response to external and internal stimuli.
Biological function summary

MAKAP facilitates the integration of cyclic adenosine monophosphate (cAMP)-dependent signaling pathways by anchoring PKA and phosphodiesterases (PDEs) within signaling complexes. It organizes these complexes at the perinuclear region and other cellular sites ensuring precise signaling. By supporting the assembly of these molecular components mAKAP regulates processes such as contractility and hypertrophy in cardiac muscle.

Pathways

MAKAP acts as a scaffold that coordinates the cAMP and calcium signaling pathways which are critical in cardiac muscle function. It interacts with PKA and PDEs to finely tune the signaling cascades that control heartbeats and muscle contraction. Furthermore mAKAP has a functional relationship with the small GTPase Ras integrating signaling inputs that modulate cell cycle and growth responses.

MAKAP has been implicated in cardiac diseases particularly in heart failure and cardiac hypertrophy. Its role in organizing signaling complexes contributes to maladaptive cardiac remodeling. mAKAP interacts with calcineurin a protein involved in cardiac hypertrophy suggesting its potential involvement in pathological conditions. Research indicates that disruptions in mAKAP-regulated signaling pathways could maladaptively affect cardiac physiology emphasizing its role in disease mechanisms.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes.
See full target information AKAP6
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Aging 12:6240-6259 PubMed32276266

2020

Inhibition of esophageal-carcinoma cell proliferation by genistein via suppression of JAK1/2-STAT3 and AKT/MDM2/p53 signaling pathways.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Gao,Rongmu Xia,Jianbo Chen,Jing Gao,Xianyang Luo,Chunlin Ke,Caihong Ren,Jiayi Li,Yanjun Mi
View all publications
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