Anti-Malate synthase G antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

Malate synthase G is involved in the conversion of lipids to carbohydrates enabling organisms to survive when carbohydrates are scarce. It functions as part of the glyoxylate cycle a modified version of the tricarboxylic acid (TCA) cycle. This enzyme operates alongside isocitrate lyase forming a critical enzyme pair within the cycle. The ability of Mycobacterium tuberculosis to utilize fatty acids as a carbon source through this pathway supports its energy production and biomass accumulation during latent infection.

Pathways

Malate synthase G integrates into the glyoxylate and dicarboxylate metabolism. It interacts closely with isocitrate lyase facilitating the bypass of the TCA cycle's decarboxylation steps. This allows the retention of carbon units for gluconeogenesis and is important for the survival of bacteria in specific environments. Malate synthase G also connects to the lipid metabolism hinting at its role in modulating energy sources under different environmental stresses.