AB178581

Anti-MALT1/MLT antibody [MT1/410]

Name: Anti-MALT1/MLT antibody [MT1/410] (ab178581) | Abcam
Brand: Abcam Limited
SKU: AB178581
Price: 495 USD
Availability: InStock

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(2 Publications)

Mouse Monoclonal MALT1/MLT antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MALT1 aa 700 to C-terminus.

View Alternative Names

MLT, MALT1, Mucosa-associated lymphoid tissue lymphoma translocation protein 1, MALT lymphoma-associated translocation, Paracaspase

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MALT1/MLT antibody [MT1/410] (AB178581)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MALT1/MLT antibody [MT1/410] (AB178581)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human tonsil tissue labeling MALT1/MLT with ab178581 at 1/200 dilution followed by peroxidase-conjugate and DAB chromogen.

Unknown

Western blot - Anti-MALT1/MLT antibody [MT1/410] (AB178581)

All lanes:

Western blot - Anti-MALT1/MLT antibody [MT1/410] (ab178581)

All lanes:

Daudi cell lysate

Predicted band size: 25 kDa,26 kDa,92 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

MT1/410

Isotype

IgG1

Light chain type

kappa

Carrier free

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human MALT1 aa 700 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9UDY8

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1-2 µg/mL", "IHCP-species-notes": "Primary incubation for 30 minutes at room temperature.Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at room temperature for 20 minutes." } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein G

Purification notes

ab212285 was purified from Bioreactor Concentrate by Protein A/G.

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: 99% PBS, 0.05% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Protease that enhances BCL10-induced activation : acts via formation of CBM complexes that channel adaptive and innate immune signaling downstream of CARD domain-containing proteins (CARD9, CARD11 and CARD14) to activate NF-kappa-B and MAP kinase p38 pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed : 11262391, PubMed : 18264101, PubMed : 24074955). Mediates BCL10 cleavage : MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion (PubMed : 11262391, PubMed : 18264101). Involved in the induction of T helper 17 cells (Th17) differentiation (PubMed : 11262391, PubMed : 18264101). Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their cooperatively repressed targets to promote Th17 cell differentiation (By similarity). Also mediates cleavage of N4BP1 in T-cells following TCR-mediated activation, leading to N4BP1 inactivation (PubMed : 31133753). May also have ubiquitin ligase activity : binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity (PubMed : 14695475).

See full target information MALT1

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 10:166 PubMed31932597

2020

Comparative Proteomic Analysis in Scar-Free Skin Regeneration in Acomys cahirinus and Scarring Mus musculus.

Applications

Unspecified application

Species

Unspecified reactive species

Jung Hae Yoon,Kun Cho,Timothy J Garrett,Paul Finch,Malcolm Maden

PloS one 12:e0169026 PubMed28052131

2017

Two Antagonistic MALT1 Auto-Cleavage Mechanisms Reveal a Role for TRAF6 to Unleash MALT1 Activation.

Applications

Unspecified application

Species

Unspecified reactive species

Stefanie Ginster,Maureen Bardet,Adeline Unterreiner,Claire Malinverni,Florian Renner,Stephen Lam,Felix Freuler,Bertran Gerrits,Johannes Voshol,Thomas Calzascia,Catherine H Régnier,Martin Renatus,Rainer Nikolay,Laura Israël,Frédéric Bornancin

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-MALT1/MLT antibody [MT1/410]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MALT1/MLT antibody [MT1/410] (AB178581)

Western blot - Anti-MALT1/MLT antibody [MT1/410] (AB178581)

Key facts

Host species

Clonality

Clone number

Isotype

Light chain type

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Product protocols

Target data

Publications (2)

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