Mouse Monoclonal MALT1/MLT antibody. Carrier free. Suitable for IHC-P, WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human MALT1 aa 700 to C-terminus.
Images
![Western blot - Anti-MALT1/MLT antibody [MT1/410] - BSA and Azide free (AB212285), expandable thumbnail](https://content.abcam.com/products/images/malt1-mlt-antibody-mt1-410-bsa-and-azide-free-ab212285--western-blot-img156030.jpg/_jcr_content/renditions/webp-475.webp "Western blot - Anti-MALT1/MLT antibody [MT1/410] - BSA and Azide free (AB212285)")
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MALT1/MLT antibody [MT1/410] - BSA and Azide free (AB212285), expandable thumbnail](https://content.abcam.com/products/images/malt1-mlt-antibody-mt1-410-bsa-and-azide-free-ab212285--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img23289.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MALT1/MLT antibody [MT1/410] - BSA and Azide free (AB212285)")
Key facts
- Isotype
- IgG1
- Host species
- Mouse
- Storage buffer
pH: 7.2 - 7.4
Constituents: 100% PBS- Form
- Liquid
- Clonality
- Monoclonal
Immunogen
- Recombinant Fragment Protein within Human MALT1 aa 700 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q9UDY8
Reactivity data
Select an application| IHC-P | WB | |
|---|---|---|
| Human | Tested | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 0.5-1 µg/mL | Notes (Primary incubation for 30 minutes at RT) Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 0.5-1 µg/mL | Notes - |
Associated Products
Select an associated product type
1 product for Alternative Version
6 products for Alternative Product
Target data
Function
Protease that enhances BCL10-induced activation: acts via formation of CBM complexes that channel adaptive and innate immune signaling downstream of CARD domain-containing proteins (CARD9, CARD11 and CARD14) to activate NF-kappa-B and MAP kinase p38 pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:11262391, PubMed:18264101, PubMed:24074955). Mediates BCL10 cleavage: MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion (PubMed:11262391, PubMed:18264101). Involved in the induction of T helper 17 cells (Th17) differentiation (PubMed:11262391, PubMed:18264101). Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their cooperatively repressed targets to promote Th17 cell differentiation (By similarity). Also mediates cleavage of N4BP1 in T-cells following TCR-mediated activation, leading to N4BP1 inactivation (PubMed:31133753). May also have ubiquitin ligase activity: binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity (PubMed:14695475).
Alternative names
MLT, MALT1, Mucosa-associated lymphoid tissue lymphoma translocation protein 1, MALT lymphoma-associated translocation, Paracaspase
Recommended products
Mouse Monoclonal MALT1/MLT antibody. Carrier free. Suitable for IHC-P, WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human MALT1 aa 700 to C-terminus.
Key facts
- Isotype
- IgG1
- Host species
- Mouse
- Storage buffer
pH: 7.2 - 7.4
Constituents: 100% PBS- Form
- Liquid
- Clonality
- Monoclonal
- Immunogen
- Recombinant Fragment Protein within Human MALT1 aa 700 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q9UDY8
- Carrier free
- Yes
- Clone number
- MT1/410
- Purification technique
- Affinity purification Protein A/G
- Light chain type
- kappa
- Concentration
- Purification notes
ab212285 was purified from Bioreactor Concentrate by Protein A/G.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
2 product images
![Western blot - Anti-MALT1/MLT antibody [MT1/410] - BSA and Azide free (ab212285), expandable thumbnail](https://content.abcam.com/products/images/malt1-mlt-antibody-mt1-410-bsa-and-azide-free-ab212285--western-blot-img156030.jpg "Western blot - Anti-MALT1/MLT antibody [MT1/410] - BSA and Azide free (ab212285)")
Western blot - Anti-MALT1/MLT antibody [MT1/410] - BSA and Azide free (ab212285)
All lanes: Western blot - Anti-MALT1/MLT antibody [MT1/410] - BSA and Azide free (ab212285) at 1 µg/mL
All lanes: Daudi cell lysate
Predicted band size: 92 kDa
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MALT1/MLT antibody [MT1/410] - BSA and Azide free (ab212285), expandable thumbnail](https://content.abcam.com/products/images/malt1-mlt-antibody-mt1-410-bsa-and-azide-free-ab212285--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img23289.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MALT1/MLT antibody [MT1/410] - BSA and Azide free (ab212285)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MALT1/MLT antibody [MT1/410] - BSA and Azide free (ab212285)
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human tonsil tissue labeling MALT1/MLT with ab212285 at 1 μg/ml.
Downloads
Product protocols
- Visit the general protocols
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