Mouse Monoclonal Mammaglobin A antibody. Carrier free. Suitable for IHC-P, WB, Protein Array and reacts with Human, Recombinant full length protein - Human samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human SCGB2A2.
Images
![Protein Array - Anti-Mammaglobin A antibody [MGB1/2000] - BSA and Azide free (AB237862), expandable thumbnail](https://content.abcam.com/products/images/mammaglobin-a-antibody-mgb1-2000-bsa-and-azide-free-ab237862--protein-array-img1245.jpg/_jcr_content/renditions/webp-475.webp "Protein Array - Anti-Mammaglobin A antibody [MGB1/2000] - BSA and Azide free (AB237862)")
![Western blot - Anti-Mammaglobin A antibody [MGB1/2000] - BSA and Azide free (AB237862), expandable thumbnail](https://content.abcam.com/products/images/mammaglobin-a-antibody-mgb1-2000-bsa-and-azide-free-ab237862--western-blot-img46160.jpg/_jcr_content/renditions/webp-475.webp "Western blot - Anti-Mammaglobin A antibody [MGB1/2000] - BSA and Azide free (AB237862)")
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Mammaglobin A antibody [MGB1/2000] - BSA and Azide free (AB237862), expandable thumbnail](https://content.abcam.com/products/images/mammaglobin-a-antibody-mgb1-2000-bsa-and-azide-free-ab237862--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img108289.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Mammaglobin A antibody [MGB1/2000] - BSA and Azide free (AB237862)")
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Mammaglobin A antibody [MGB1/2000] - BSA and Azide free (AB237862), expandable thumbnail](https://content.abcam.com/products/images/mammaglobin-a-antibody-mgb1-2000-bsa-and-azide-free-ab237862--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img132118.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Mammaglobin A antibody [MGB1/2000] - BSA and Azide free (AB237862)")
Key facts
- Isotype
- IgG1
- Host species
- Mouse
- Storage buffer
pH: 7.2 - 7.4
Constituents: PBS- Form
- Liquid
- Clonality
- Monoclonal
Immunogen
- Recombinant Full Length Protein corresponding to Human SCGB2A2. Database link Q13296
Reactivity data
Select an application| IHC-P | WB | Protein Array | |
|---|---|---|---|
| Human | Tested | Tested | Expected |
| Recombinant full length protein - Human | Not recommended | Not recommended | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 0.1-0.2 µg/mL | Notes Incubate with primary antibody for 30 minutes at RT Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Not recommendedNot recommended
| Species | Dilution info | Notes |
|---|---|---|
Species Recombinant full length protein - Human | Dilution info - | Notes - |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1-2 µg/mL | Notes - |
Not recommendedNot recommended
| Species | Dilution info | Notes |
|---|---|---|
Species Recombinant full length protein - Human | Dilution info - | Notes - |
Protein Array
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Recombinant full length protein - Human | Dilution info - | Notes - |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info Use at an assay dependent concentration. | Notes - |
Associated Products
Select an associated product type
5 products for Alternative Product
1 product for Alternative Version
Target data
Alternative names
MGB1, UGB2, SCGB2A2, Mammaglobin-A, Mammaglobin-1, Secretoglobin family 2A member 2
Recommended products
Mouse Monoclonal Mammaglobin A antibody. Carrier free. Suitable for IHC-P, WB, Protein Array and reacts with Human, Recombinant full length protein - Human samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human SCGB2A2.
Key facts
- Isotype
- IgG1
- Host species
- Mouse
- Storage buffer
pH: 7.2 - 7.4
Constituents: PBS- Form
- Liquid
- Clonality
- Monoclonal
- Immunogen
- Recombinant Full Length Protein corresponding to Human SCGB2A2. Database link Q13296
- Carrier free
- Yes
- Clone number
- MGB1/2000
- Purification technique
- Affinity purification Protein A/G
- Light chain type
- kappa
- Concentration
- Purification notes
Purified from Bioreactor Concentrate by Protein A/G.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Mammaglobin A also known as MGB1 is a breast-specific protein of approximately 93 amino acids with a molecular mass of about 15 kDa. It has a high expression in mammary tissue and limited expression in other tissues like the sweat glands. Researchers use immunohistochemistry (IHC) to detect Mammaglobin in tissue samples because of its tissue-specific expression making it a useful marker for breast epithelium.
- Biological function summary
Mammaglobin A functions as a glycoprotein. Its precise biological role remains unclear but scientists propose it plays a role in secretory processes due to its presence in epithelial cells of the mammary glands. This protein itself is not known to participate in a larger complex. The significance of Mammaglobin A as a marker rather than an active enzyme or receptor suggests its potential involvement in processes specific to breast tissue.
- Pathways
Mammaglobin A interacts within pathways involving sex steroid hormone signaling reflecting its expression in mammary tissue. This protein's expression is possibly regulated by hormonal pathways like the estrogen pathway which plays a significant role in breast tissue development and differentiation. It does not actively participate with related proteins but might be an indicator of pathway activities associated with specific tissues or conditions.
- Associated diseases and disorders
Mammaglobin A is prominently associated with breast cancer. Its specific expression in breast tissue makes it a valuable marker for detecting disseminated breast tumor cells. Although it does not directly interact with proteins involved in cancer progression like HER2 or ER (estrogen receptor) its expression levels serve as an important biomarker for diagnosis and monitoring treatment response. Researchers continue to explore its potential utility in understanding breast cancer biology and improving clinical outcomes.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
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4 product images
![Protein Array - Anti-Mammaglobin A antibody [MGB1/2000] - BSA and Azide free (ab237862), expandable thumbnail](https://content.abcam.com/products/images/mammaglobin-a-antibody-mgb1-2000-bsa-and-azide-free-ab237862--protein-array-img1245.jpg "Protein Array - Anti-Mammaglobin A antibody [MGB1/2000] - BSA and Azide free (ab237862)")
Protein Array - Anti-Mammaglobin A antibody [MGB1/2000] - BSA and Azide free (ab237862)
This data was produced with Anti-Mammaglobin A antibody [MGB1/2000] ab238018, the same antibody in a different formulation with BSA and Azide.
Anti-Mammaglobin A antibody [MGB1/2000] ab238018 was tested in protein array against over 19000 different full-length human proteins.
Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.
A MAb is specific to its intended target if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.![Western blot - Anti-Mammaglobin A antibody [MGB1/2000] - BSA and Azide free (ab237862), expandable thumbnail](https://content.abcam.com/products/images/mammaglobin-a-antibody-mgb1-2000-bsa-and-azide-free-ab237862--western-blot-img46160.jpg "Western blot - Anti-Mammaglobin A antibody [MGB1/2000] - BSA and Azide free (ab237862)")
Western blot - Anti-Mammaglobin A antibody [MGB1/2000] - BSA and Azide free (ab237862)
All lanes: Western blot - Anti-Mammaglobin A antibody [MGB1/2000] - BSA and Azide free (ab237862)
All lanes: SK-BR3 cell lysate
Predicted band size: 10 kDa
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Mammaglobin A antibody [MGB1/2000] - BSA and Azide free (ab237862), expandable thumbnail](https://content.abcam.com/products/images/mammaglobin-a-antibody-mgb1-2000-bsa-and-azide-free-ab237862--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img108289.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Mammaglobin A antibody [MGB1/2000] - BSA and Azide free (ab237862)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Mammaglobin A antibody [MGB1/2000] - BSA and Azide free (ab237862)
Formalin-fixed, paraffin-embedded human breast carcinoma tissue stained for Mammaglocin A using ab237862 at 0.2 μg/ml in immunohistochemical analysis.
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Mammaglobin A antibody [MGB1/2000] - BSA and Azide free (ab237862), expandable thumbnail](https://content.abcam.com/products/images/mammaglobin-a-antibody-mgb1-2000-bsa-and-azide-free-ab237862--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img132118.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Mammaglobin A antibody [MGB1/2000] - BSA and Azide free (ab237862)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Mammaglobin A antibody [MGB1/2000] - BSA and Azide free (ab237862)
Formalin-fixed, paraffin-embedded human breast carcinoma tissue stained for Mammaglocin A using ab237862 at 0.2 μg/ml in immunohistochemical analysis.
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