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Mouse Monoclonal Mannose Receptor antibody. Suitable for IHC-Fr and reacts with Human samples. Cited in 78 publications. Immunogen corresponding to Native Full Length Protein corresponding to Human MRC1.


Images

Immunohistochemistry (Frozen sections) - Anti-Mannose Receptor antibody [15-2] (AB8918), expandable thumbnail
  • Immunohistochemistry (Frozen sections) - Anti-Mannose Receptor antibody [15-2] (AB8918), expandable thumbnail
  • Immunohistochemistry (Frozen sections) - Anti-Mannose Receptor antibody [15-2] (AB8918), expandable thumbnail
  • Immunohistochemistry (Frozen sections) - Anti-Mannose Receptor antibody [15-2] (AB8918), expandable thumbnail

Publications

Key facts

Isotype
IgG1
Host species
Mouse
Storage buffer

Constituents: PBS, 0.1% BSA

Form
Liquid
Clonality
Monoclonal

Immunogen

  • Native Full Length Protein corresponding to Human MRC1. Database link P22897

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
IHC-PIHC-Fr
Human
Not recommended
Tested

Not recommended
Not recommended

Species
Human
Dilution info
-
Notes

-

Tested
Tested

Species
Human
Dilution info
1/50
Notes

-

Associated Products

Select an associated product type

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Target data

Function

Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. (Microbial infection) Acts as a phagocytic receptor for bacteria, fungi and other pathogens. (Microbial infection) Acts as a receptor for Dengue virus envelope protein E. (Microbial infection) Interacts with Hepatitis B virus envelope protein.

Alternative names

CD206, CLEC13D, CLEC13DL, MRC1L1, MRC1, Macrophage mannose receptor 1, MMR, C-type lectin domain family 13 member D, C-type lectin domain family 13 member D-like, Human mannose receptor, Macrophage mannose receptor 1-like protein 1, hMR

Recommended products

Mouse Monoclonal Mannose Receptor antibody. Suitable for IHC-Fr and reacts with Human samples. Cited in 78 publications. Immunogen corresponding to Native Full Length Protein corresponding to Human MRC1.

Key facts

Isotype
IgG1
Form
Liquid
Clonality
Monoclonal
Immunogen
  • Native Full Length Protein corresponding to Human MRC1. Database link P22897
Clone number
15-2
Purification technique
Affinity purification Protein G
Epitope
Stains extracellular domain of Mannose Receptor.
Light chain type
unknown
Concentration
Loading...
Purification notes

0.2 µm filtered antibody solution

Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Notes

The Mannose Receptor (MR), a member of the vertebrate C-type lectin family, is a pattern recognition receptor that is involved in both innate and adaptive immunity. The 180 kDa transmembrane protein consists of 5 domains: an amino-terminal cysteine-rich region, a fibronectin type II repeat, a series of eight tandem lectin-like carbohydrate recognition domains (responsible for the recognition of mannose and fucose), a transmembrane domain, and an intracellular carboxy-terminal tail. The structure is shared by the family of multi lectin mannose receptors: the phospholipase A2-receptor, DEC 205 and the novel C-type lectin receptor (mannose receptor X). The MR recognises a wide range of gram positive and gram negative bacteria, yeasts, parasites and mycobacteria. The MR has also been shown to bind and internalize tissue-type plasminogen activator. MR's are present on monocytes and dendritic cells (DC) and are presumed to play a role in innate and adaptive immunity, the latter via processing by DC. The expression of MR as observed in immunohistology is present on tissue macrophages, dendritic cells, a subpopulation of endothelial cells, Kupffer cells and sperm cells.

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Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.
Activity summary

The Mannose Receptor also known as CD206 or MRC1 is a type of C-type lectin receptor with a molecular weight of 175 kDa. It is expressed on the surface of macrophages and dendritic cells. This receptor binds to complex carbohydrates like mannose and fucose found on pathogen surfaces playing an important role in their recognition. Mannose Receptors act as endocytic receptors aiding in the internalization and degradation of pathogens.

Biological function summary

The Mannose Receptor functions in pathogen recognition and clearance by binding to specific carbohydrates on the pathogen's surface. It is not part of a larger molecular complex but works independently to facilitate phagocytosis. The receptor is essential in immune responses allowing macrophages and dendritic cells to efficiently capture and process antigens for presentation to T cells. This enables the initiation of adaptive immune responses.

Pathways

Researchers know that the Mannose Receptor plays an important role in immune signaling pathways particularly in antigen processing and presentation. It interacts with proteins involved in these pathways including those necessary for the internalization and degradation of bound antigens. Moreover it works alongside scavenger receptors contributing to the regulation of immune and inflammatory responses.

Associated diseases and disorders

The Mannose Receptor is often linked to pulmonary tuberculosis and certain types of cancer. When macrophages express this receptor it can modulate immune responses against Mycobacterium tuberculosis by aiding in its recognition. In cancer altered expression of CD206 can indicate tumor-associated macrophages which promote tumor growth by suppressing immune responses. These connections highlight the receptor's potential as a diagnostic marker and therapeutic target.

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4 product images

  • Immunohistochemistry (Frozen sections) - Anti-Mannose Receptor antibody [15-2] (ab8918), expandable thumbnail

    Immunohistochemistry (Frozen sections) - Anti-Mannose Receptor antibody [15-2] (ab8918)

    Frozen sections of human tonsil. ab8918 was used in a dilution of 1/25 and shows staining of endothelia of lymph vessels.

  • Immunohistochemistry (Frozen sections) - Anti-Mannose Receptor antibody [15-2] (ab8918), expandable thumbnail
    This image is a courtesy of Pat Bell

    Immunohistochemistry (Frozen sections) - Anti-Mannose Receptor antibody [15-2] (ab8918)

    ab8918 staining Mannose Receptor in human mammary gland tissue section by Immunohistochemistry (Frozen sections). Tissue samples were fixed with 70% Ethanol and blocking for 10 minutes at RT was performed. The sample was incubated with primary antibody (1/10) for 1 hour. A HRP-conjugated mouse polyclonal to mouse IgG was used undiluted as secondary antibody.

  • Immunohistochemistry (Frozen sections) - Anti-Mannose Receptor antibody [15-2] (ab8918), expandable thumbnail
    This image is courtesy of an anonymous customer review

    Immunohistochemistry (Frozen sections) - Anti-Mannose Receptor antibody [15-2] (ab8918)

    Immunohistochemical analysis of murine uterus tissue sections, staining Mannose Receptor with ab8918.

    Tissue was fixed with paraformaldehyde and blocked with 3% BSA for 30 minutes at room temperature. Samples were incubated with primary antibody (1/40 in 1% BSA) for 1.5 hours. An undiluted HRP-conjugated rabbit anti-mouse polyclonal IgG was used as the secondary antibody.

  • Immunohistochemistry (Frozen sections) - Anti-Mannose Receptor antibody [15-2] (ab8918), expandable thumbnail
    This image is courtesy of a customer review submitted by Aimée-Lys Rusesabagina

    Immunohistochemistry (Frozen sections) - Anti-Mannose Receptor antibody [15-2] (ab8918)

    ab8918 staining Mannose Receptor in human endometriosis tissue sections by Immunohistochemistry (IHC-Fr - frozen sections). Tissue was fixed with acetone and blocked with 10% serum for 1 hour at 22°C. Samples were incubated with primary antibody (1/10 in PBS + 1% NGS) for 16 hours at 4°C. An undiluted HRP-conjugated goat anti-mouse IgG polyclonal was used as the secondary antibody.

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