AB270634

Anti-Mannose Receptor antibody [15-2] - Low endotoxin, Azide free

Name: Anti-Mannose Receptor antibody [15-2] - Low endotoxin, Azide free (ab270634) | Abcam
Brand: Abcam Limited
SKU: AB270634

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(2 Publications)

Mouse Monoclonal Mannose Receptor antibody. Carrier free. Suitable for Flow Cyt and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Native Full Length Protein corresponding to Human MRC1.

View Alternative Names

CD206, CLEC13D, CLEC13DL, MRC1L1, MRC1, Macrophage mannose receptor 1, MMR, C-type lectin domain family 13 member D, C-type lectin domain family 13 member D-like, Human mannose receptor, Macrophage mannose receptor 1-like protein 1, hMR

2 Images

Flow Cytometry - Anti-Mannose Receptor antibody [15-2] - Low endotoxin, Azide free (AB270634)

Flow Cyt

Supplier Data

Flow Cytometry - Anti-Mannose Receptor antibody [15-2] - Low endotoxin, Azide free (AB270634)

Flow cytometry analysis of human monocytes labeling Mannose receptor using ab270634, followed by goat anti-mouse (GAM) PE. Concentration in sample of 9 μg/ml.

Flow Cyt

Supplier Data

Flow Cytometry - Anti-Mannose Receptor antibody [15-2] - Low endotoxin, Azide free (AB270634)

Flow cytometry analysis of human dentritic cells (red) and non-stimulated lymphocytes (black-dashed) labeling mannose receptor using ab270634, followed by a goat anti-mouse (GAM) PE. Concentration in sample of 9 μg/ml.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

15-2

Isotype

IgG1

Light chain type

kappa

Carrier free

Yes

Reacts with

Human

Applications

Flow Cyt

applications

Immunogen

Native Full Length Protein corresponding to Human MRC1.

P22897

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1-4 µg/mL", "FlowCyt-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.4 Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Mannose Receptor also known as CD206 or MRC1 is a type of C-type lectin receptor with a molecular weight of 175 kDa. It is expressed on the surface of macrophages and dendritic cells. This receptor binds to complex carbohydrates like mannose and fucose found on pathogen surfaces playing an important role in their recognition. Mannose Receptors act as endocytic receptors aiding in the internalization and degradation of pathogens.

Biological function summary

The Mannose Receptor functions in pathogen recognition and clearance by binding to specific carbohydrates on the pathogen's surface. It is not part of a larger molecular complex but works independently to facilitate phagocytosis. The receptor is essential in immune responses allowing macrophages and dendritic cells to efficiently capture and process antigens for presentation to T cells. This enables the initiation of adaptive immune responses.

Pathways

Researchers know that the Mannose Receptor plays an important role in immune signaling pathways particularly in antigen processing and presentation. It interacts with proteins involved in these pathways including those necessary for the internalization and degradation of bound antigens. Moreover it works alongside scavenger receptors contributing to the regulation of immune and inflammatory responses.

The Mannose Receptor is often linked to pulmonary tuberculosis and certain types of cancer. When macrophages express this receptor it can modulate immune responses against Mycobacterium tuberculosis by aiding in its recognition. In cancer altered expression of CD206 can indicate tumor-associated macrophages which promote tumor growth by suppressing immune responses. These connections highlight the receptor's potential as a diagnostic marker and therapeutic target.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains.. (Microbial infection) Acts as a phagocytic receptor for bacteria, fungi and other pathogens.. (Microbial infection) Acts as a receptor for Dengue virus envelope protein E.. (Microbial infection) Interacts with Hepatitis B virus envelope protein.

See full target information MRC1

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Mediators of inflammation 2025:9021628 PubMed40757051

2025

HBP21 Alleviates Sepsis-Induced Acute Kidney Injury by Targeting PI3K/AKT-Mediated M1 Macrophage Polarization.

Applications

Unspecified application

Species

Unspecified reactive species

Na An,Mingzhi Xu,Ruman Chen,Cuijuan Wang,Yafei Bai

Biotechnology and applied biochemistry 72:355-368 PubMed39279255

2024

Salidroside alleviates imiquimod-induced psoriasis by inhibiting GSDMD-driven keratinocyte pyroptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Mengjie Wang,Tuyagaer Tu,Yangxingyun Wang,Limin Tian,Yuenan Yang

View all publications

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Product promise

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For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-Mannose Receptor antibody [15-2] - Low endotoxin, Azide free

Flow Cytometry - Anti-Mannose Receptor antibody [15-2] - Low endotoxin, Azide free (AB270634)

Flow Cytometry - Anti-Mannose Receptor antibody [15-2] - Low endotoxin, Azide free (AB270634)

Key facts

Host species

Clonality

Clone number

Isotype

Light chain type

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (2)

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