Rabbit Polyclonal MAPRE1/EB1 antibody. Suitable for IHC-P and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human MAPRE1 aa 200 to C-terminus.
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Publications
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- Oncotarget 9:24291-243032018A novel liver metastasis-correlated protein of pancreatic neuroendocrine neoplasm (PanNEN) discovered by proteomic analysis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMitsuhiro Shimura et. al.PubMed 29849941
- The Journal of cell biology 206:779-972014Disease mutations in desmoplakin inhibit Cx43 membrane targeting mediated by desmoplakin-EB1 interactions.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDipal M Patel,Adi D Dubash,Geri Kreitzer,Kathleen J GreenPubMed 25225338
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 6.8 - 7.4
Preservative: 0.09% Sodium azide
Constituents: 99% Tris buffered saline, 0.1% BSA- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human MAPRE1 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q15691
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
| Mouse | Tested |
| Rat | Predicted |
| Chimpanzee | Predicted |
| Cow | Predicted |
| Dog | Predicted |
| Goat | Predicted |
| Gorilla | Predicted |
| Guinea pig | Predicted |
| Horse | Predicted |
| Orangutan | Predicted |
| Pig | Predicted |
| Rabbit | Predicted |
| Rhesus monkey | Predicted |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1/100.00000 - 1/500.00000 | Notes ab117821 can also be used for IHC-IF. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining. |
Species Human | Dilution info 1/100.00000 - 1/500.00000 | Notes ab117821 can also be used for IHC-IF. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining. |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Rat, Goat, Horse, Guinea pig, Cow, Dog, Pig, Chimpanzee, Rhesus monkey, Gorilla, Orangutan, Rabbit | Dilution info - | Notes - |
Associated Products
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Target data
Function
Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:23001180, PubMed:28726242, PubMed:28814570, PubMed:34608293). Recruits other +TIP proteins to microtubules by binding to a conserved Ser-X-Leu-Pro (SXLP) motif in their polypeptide chains (PubMed:19632184, PubMed:36592928). Promotes cytoplasmic microtubule nucleation and elongation (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:28726242, PubMed:28814570). Involved in mitotic spindle positioning by stabilizing microtubules and promoting dynamic connection between astral microtubules and the cortex during mitotic chromosome segregation (PubMed:12388762, PubMed:34608293). Assists chromosome alignment in metaphase by recruiting the SKA complex to the spindle and stabilizing its interactions with microtubule bundles (K-fibers) (PubMed:27225956, PubMed:36592928). Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:28814570). Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed:28814570). Acts as a regulator of autophagosome transport via interaction with CAMSAP2 (PubMed:28726242). Functions downstream of Rho GTPases and DIAPH1 in stable microtubule formation (By similarity). May play a role in cell migration (By similarity).
Alternative names
Microtubule-associated protein RP/EB family member 1, APC-binding protein EB1, End-binding protein 1, EB1, MAPRE1
Recommended products
Rabbit Polyclonal MAPRE1/EB1 antibody. Suitable for IHC-P and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human MAPRE1 aa 200 to C-terminus.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 6.8 - 7.4
Preservative: 0.09% Sodium azide
Constituents: 99% Tris buffered saline, 0.1% BSA- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human MAPRE1 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q15691
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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Full details and terms and conditions can be found here:
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3 product images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MAPRE1/EB1 antibody (ab117821)
Detection of Human MAPRE1/EB1 by Immunohistochemistry. Sample: Formalin Fixed Paraffin Embedded section of Human prostate carcinoma. Antibody: ab117821 used at a dilution of 1/100. Detection: Red-fluorescent Goat anti-Rabbit IgG heavy and light chain cross-adsorbed Antibody DyLight 594 Conjugated used at a dilution of 1/100.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MAPRE1/EB1 antibody (ab117821)
Immunohistochemical detection of Human MAPRE1/EB1 in paraffin embedded formalin fixed Human prostate carcinoma tissue section using 1/250 ab117821. DAB detection.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MAPRE1/EB1 antibody (ab117821)
Immunohistochemical detection of Mouse MAPRE1/EB1 in paraffin embedded formalin fixed Mouse teratoma tissue section using 1/250 ab117821. DAB detection.
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