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AB252962

Anti-MASA antibody

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(1 Publication)

Rabbit Polyclonal MASA antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ENOPH1 aa 1-100.

View Alternative Names

MASA, MSTP145, ENOPH1, Enolase-phosphatase E1, MASA homolog

4 Images
Immunocytochemistry/ Immunofluorescence - Anti-MASA antibody (AB252962)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-MASA antibody (AB252962)

PFA-fixed, Triton X-100 permeabilized MCF7 (Human breast adenocarcinoma cell line) cells stained for MASA (green) using ab252962 at 4 μg/ml in ICC/IF.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MASA antibody (AB252962)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MASA antibody (AB252962)

Paraffin-embedded human pancreas tissue stained for MASA using ab252962 at 1/50 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MASA antibody (AB252962)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MASA antibody (AB252962)

Paraffin-embedded human cerebral cortex tissue stained for MASA using ab252962 at 1/50 dilution in immunohistochemical analysis.

Western blot - Anti-MASA antibody (AB252962)
  • WB

Unknown

Western blot - Anti-MASA antibody (AB252962)

All lanes:

Western blot - Anti-MASA antibody (ab252962) at 0.4 µg/mL

Lane 2:

Vector only transfected HEK293T lysate

Lane 3:

Over-expressing ENOPH1 Hek293T cells

Predicted band size: 28 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human ENOPH1 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

Q9UHY7

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The MASA protein also known simply as MASA presents a molecular mass of approximately 60 kDa. MASA is expressed predominantly in neuronal tissues with specific abundance in areas of the brain linked to cognitive functions. This protein resides within the cytoplasm and shows a strong presence in neurons suggesting its role in nervous system operations. The MASA protein has gathered significant interest in neuroscience for its contribution to cellular processes.
Biological function summary

The MASA protein plays a critical role in cellular communication within neurons. It does not generally form part of a larger protein complex but interacts directly with other proteins to modulate synaptic transmission. Researchers have demonstrated that it influences the release of neurotransmitters impacting neuronal excitability and synaptic plasticity. This protein through its actions is vital for maintaining the functional network among neural cells.

Pathways

MASA protein involves itself in signaling pathways related to synaptic function and plasticity. One of the key pathways includes the NMDA receptor pathway where MASA interacts with proteins like PSD-95. There is also significant interaction with proteins involved in the MAPK signaling pathway. The ability of MASA to influence these pathways points to its integral function in regulating synaptic strength and memory formation in the brain.

Researchers have found associations between MASA protein and certain neurodegenerative diseases. Alzheimer's disease presents strong connections with MASA as the protein appears to influence amyloid-beta processing. In addition the MASA protein has possible links to schizophrenia potentially connected through its interactions with disrupted-in-schizophrenia-1 (DISC1) proteins. These relationships highlight MASA as a potential target for therapeutic strategies aimed at treating neurological disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
See full target information ENOPH1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 16:6876 PubMed40715139

2025

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Applications

Unspecified application

Species

Unspecified reactive species

Yingchao Xue,Elizabeth Winnicki,Zhaoxu Zhang,Ines Lopez,Saifeng Wang,Charles Kirby,Sam S Lee,Ang Li,Chaewon Lee,Hana Minsky,Kaitlin Williams,Kevin Yueh-Hsun Yang,Ling He,Sashank K Reddy,Luis A Garza
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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