AB111239

Anti-Mast Cell Chymase antibody

Name: Anti-Mast Cell Chymase antibody (ab111239) | Abcam
Brand: Abcam Limited
SKU: AB111239
Rating: 5 (1 reviews)

(1 Review)

(9 Publications )

Goat Polyclonal Mast Cell Chymase antibody. Suitable for IHC-P and reacts with Human samples. Cited in 9 publications. Immunogen corresponding to Synthetic Peptide within Human CMA1 aa 50-150.

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Mast Cell Chymase antibody (AB111239)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Mast Cell Chymase antibody (AB111239)

ab111239, at 1.5 µg/ml, staining Mast Cell Chymase in formalin fixed, paraffin embedded Human testis tissue by Immunohistochemistry. Biotinylated secondary antibody, followed by alkaline phosphatase streptavidin and chromogen were used to develop staining.

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Mast Cell Chymase antibody (AB111239)

ab111239, at 1.5 µg/ml, staining Mast Cell Chymase in formalin fixed, paraffin embedded Human tonsil tissue by Immunohistochemistry. Biotinylated secondary antibody, followed by alkaline phosphatase streptavidin and chromogen were used to develop staining.

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human CMA1 aa 50-150. The exact immunogen used to generate this antibody is proprietary information.

P23946

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1.5-3.75 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.3 Preservative: 0.02% Sodium azide Constituents: Tris buffered saline, 0.5% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.

See full target information CMA1

Alternative Names

CYH, CYM, CMA1, Chymase, Alpha-chymase, Mast cell protease I

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Publications (9)

Recent publications for all applications. Explore the full listand refine your search

Journal of the American Heart Association 12:e028056 PubMed36752268

2023

Chymase Inhibition Resolves and Prevents Deep Vein Thrombosis Without Increasing Bleeding Time in the Mouse Model.

Applications

Unspecified application

Species

Unspecified reactive species

Catherine Lapointe,Laurence Vincent,Hugo Giguère,Mannix Auger-Messier,Adel Schwertani,Denan Jin,Shinji Takai,Gunnar Pejler,Martin G Sirois,Hanna Tinel,Stefan Heitmeier,Pedro D'Orléans-Juste

Cell genomics 2: PubMed36419822

2022

Spatial intra-tumor heterogeneity is associated with survival of lung adenocarcinoma patients.

Applications

Unspecified application

Species

Unspecified reactive species

Hua-Jun Wu,Daniel Temko,Zoltan Maliga,Andre L Moreira,Emi Sei,Darlan Conterno Minussi,Jamie Dean,Charlotte Lee,Qiong Xu,Guillaume Hochart,Connor A Jacobson,Clarence Yapp,Denis Schapiro,Peter K Sorger,Erin H Seeley,Nicholas Navin,Robert J Downey,Franziska Michor

Acta neuropathologica communications 9:136 PubMed34389060

2021

The pathogenic role of c-Kit+ mast cells in the spinal motor neuron-vascular niche in ALS.

Applications

Unspecified application

Species

Unspecified reactive species

Mariángeles Kovacs,Catalina Alamón,Cecilia Maciel,Valentina Varela,Sofía Ibarburu,Lucas Tarragó,Peter H King,Ying Si,Yuri Kwon,Olivier Hermine,Luis Barbeito,Emiliano Trias

International journal of molecular sciences 22: PubMed33803422

2021

Stress and Nasal Allergy: Corticotropin-Releasing Hormone Stimulates Mast Cell Degranulation and Proliferation in Human Nasal Mucosa.

Applications

Unspecified application

Species

Unspecified reactive species

Mika Yamanaka-Takaichi,Yukari Mizukami,Koji Sugawara,Kishiko Sunami,Yuichi Teranishi,Yukimi Kira,Ralf Paus,Daisuke Tsuruta

Glia 68:1165-1181 PubMed31859421

2019

Schwann cells orchestrate peripheral nerve inflammation through the expression of CSF1, IL-34, and SCF in amyotrophic lateral sclerosis.

Applications

Unspecified application

Species

Unspecified reactive species

Emiliano Trias,Mariángeles Kovacs,Peter H King,Ying Si,Yuri Kwon,Valentina Varela,Sofía Ibarburu,Ivan C Moura,Olivier Hermine,Joseph S Beckman,Luis Barbeito

JCI insight 3: PubMed30282815

2018

Mast cells and neutrophils mediate peripheral motor pathway degeneration in ALS.

Applications

Unspecified application

Species

Unspecified reactive species

Emiliano Trias,Peter H King,Ying Si,Yuri Kwon,Valentina Varela,Sofía Ibarburu,Mariángeles Kovacs,Ivan C Moura,Joseph S Beckman,Olivier Hermine,Luis Barbeito

PloS one 13:e0192963 PubMed29529050

2018

Transmembrane protease, serine 4 (TMPRSS4) is upregulated in IPF lungs and increases the fibrotic response in bleomycin-induced lung injury.

Applications

Unspecified application

Species

Unspecified reactive species

Ana Valero-Jiménez,Joaquín Zúñiga,José Cisneros,Carina Becerril,Alfonso Salgado,Marco Checa,Ivette Buendía-Roldán,Criselda Mendoza-Milla,Miguel Gaxiola,Annie Pardo,Moisés Selman

American journal of physiology. Gastrointestinal and liver physiology 310:G13-25 PubMed26514775

2015

Elevated IL-33 expression is associated with pediatric eosinophilic esophagitis, and exogenous IL-33 promotes eosinophilic esophagitis development in mice.

Applications

Unspecified application

Species

Mouse

L M Judd,R G Heine,T R Menheniott,J Buzzelli,N O'Brien-Simpson,D Pavlic,L O'Connor,K Al Gazali,O Hamilton,M Scurr,A M Collison,J Mattes,K J Allen,A S Giraud

Cellular and molecular gastroenterology and hepato 1:203-221.e3 PubMed28210674

2015

IL33 Is a Stomach Alarmin That Initiates a Skewed Th2 Response to Injury and Infection.

Applications

Unspecified application

Species

Unspecified reactive species

Jon N Buzzelli,Heather V Chalinor,Daniel I Pavlic,Philip Sutton,Trevelyan R Menheniott,Andrew S Giraud,Louise M Judd

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Mast Cell Chymase antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Mast Cell Chymase antibody (AB111239)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Mast Cell Chymase antibody (AB111239)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Product protocols

Target data

Alternative Names

Publications (9)

Product promise