Rabbit Polyclonal Matrin 3 antibody. Suitable for IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human MATR3 aa 800 to C-terminus.
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Publications
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- Biology 11:2022Selective Loss of MATR3 in Spinal Interneurons, Upper Motor Neurons and Hippocampal CA1 Neurons in a MATR3 S85C Knock-In Mouse Model of Amyotrophic Lateral Sclerosis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJustin You,Katarina Maksimovic,Jooyun Lee,Mashiat Khan,Rintaro Masuda,Jeehye ParkPubMed 35205163
- Nature communications 12:62412021Inner nuclear protein Matrin-3 coordinates cell differentiation by stabilizing chromatin architecture.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHye Ji Cha,Özgün Uyan,Yan Kai,Tianxin Liu,Qian Zhu,Zuzana Tothova,Giovanni A Botten,Jian Xu,Guo-Cheng Yuan,Job Dekker,Stuart H OrkinPubMed 34716321
- Acta neuropathologica communications 8:1772020RNA dependent suppression of C9orf72 ALS/FTD associated neurodegeneration by Matrin-3.Applications:Unspecified applicationReactive species:Unspecified reactive speciesNandini Ramesh et. al.PubMed 33129345
- Nature communications 11:53042020Selective neuronal degeneration in MATR3 S85C knock-in mouse model of early-stage ALS.Applications:Unspecified applicationReactive species:Unspecified reactive speciesChing Serena Kao et. al.PubMed 33082323
- FEBS letters 594:2800-28182020Knockdown of genes involved in axonal transport enhances the toxicity of human neuromuscular disease-linked MATR3 mutations in Drosophila.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMelody Zhao,Ching Serena Kao,Claudia Arndt,David Duc Tran,Woo In Cho,Katarina Maksimovic,Xiao Xiao Lily Chen,Mashiat Khan,Hongxian Zhu,Julia Qiao,Kailong Peng,Jingyao Hong,Jialu Xu,Deanna Kim,Jihye Rachel Kim,Jooyun Lee,Rebekah van Bruggen,Wan Hee Yoon,Jeehye ParkPubMed 32515490
- Molecular biology of the cell 27:3894-39022016Identification of novel nesprin-1 binding partners and cytoplasmic matrin-3 in processing bodies.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 6.8 - 7.4
Preservative: 0.09% Sodium azide
Constituents: Tris buffered saline, 0.1% BSA- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human MATR3 aa 800 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link P43243
Consider this alternative
Reactivity data
Select an application| IHC-P | ICC/IF | |
|---|---|---|
| Human | Tested | Tested |
| Mouse | Tested | Expected |
| Bat | Predicted | Predicted |
| Chimpanzee | Predicted | Predicted |
| Chinese hamster | Predicted | Predicted |
| Orangutan | Predicted | Predicted |
| Rhesus monkey | Predicted | Predicted |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1/100 - 1/500 | Notes Note: expected to work on frozen sections. Perform heat-mediated antigen retrieval before commencing with IHC staining protocol. |
Species Human | Dilution info 1/100 - 1/500 | Notes Note: expected to work on frozen sections. Perform heat-mediated antigen retrieval before commencing with IHC staining protocol. |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Chimpanzee, Rhesus monkey, Chinese hamster, Orangutan, Bat | Dilution info - | Notes - |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/100 | Notes - |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info Use at an assay dependent concentration. | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Chimpanzee, Rhesus monkey, Chinese hamster, Orangutan, Bat | Dilution info - | Notes - |
Associated Products
Select an associated product type
4 products for Alternative Product
Target data
Function
May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233).
Alternative names
KIAA0723, MATR3, Matrin-3
Recommended products
Rabbit Polyclonal Matrin 3 antibody. Suitable for IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human MATR3 aa 800 to C-terminus.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 6.8 - 7.4
Preservative: 0.09% Sodium azide
Constituents: Tris buffered saline, 0.1% BSA- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human MATR3 aa 800 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link P43243
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
5 product images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Matrin 3 antibody (ab84422)
Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human colon adenocarcinoma using 1/250 ab84422, followed by DAB staining.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Matrin 3 antibody (ab84422)
Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Mouse squamous cell carcinoma using 1/250 ab84422, followed by DAB staining.
Image courtesy of Leilani Beltran by customer review.Immunocytochemistry/ Immunofluorescence - Anti-Matrin 3 antibody (ab84422)
ab84422 staining Matrin 3 in human U2OS cells by Immunocytochemistry/ Immunofluorescence.
Cells were fixed in paraformaldehyde, permeabilized using 0.5% NP-40, blocked with 1% BSA for 1 hour a room temperature, then incubated with ab84422 at a 1/100 dilution for 1 hour. The secondary antibody used was an Alexa-Fluor 488 conjugate donkey polyclonal, used at a 1/1000 dilution.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Matrin 3 antibody (ab84422)
Detection of Human Matrin 3 by Immunofluorescence.
Sample: FFPE section of human breast carcinoma.
Antibody: ab84422 used at a dilution of 1/100.
Detection: Red-fluorescent Alexa Fluor 555 goat anti-rabbit IgG used at a dilution of 1/500.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Matrin 3 antibody (ab84422)
Detection of Human Matrin 3 by Immunofluorescence.
Sample: FFPE section of Human breast carcinoma.
Antibody: ab84422 used at a dilution of 1/100.
Detection: Red-fluorescent Alexa Fluor 555 goat anti-rabbit IgG used at a dilution of 1/500.
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