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AB56180

Anti-Matriptase 2 antibody - Cytoplasmic domain

5

(2 Reviews)

|

(6 Publications)

Rabbit Polyclonal Matriptase 2 antibody. Suitable for WB and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human TMPRSS6.

View Alternative Names

UNQ354/PRO618, TMPRSS6, Transmembrane protease serine 6, Matriptase-2

1 Images
Western blot - Anti-Matriptase 2 antibody - Cytoplasmic domain (AB56180)
  • WB

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Western blot - Anti-Matriptase 2 antibody - Cytoplasmic domain (AB56180)

All lanes:

Western blot - Anti-Matriptase 2 antibody - Cytoplasmic domain (ab56180) at 1/1000 dilution

All lanes:

Cell media from human embryonic kidney HEK293 cells

Predicted band size: 90 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human TMPRSS6. The exact immunogen used to generate this antibody is proprietary information.

Q8IU80

Specificity

ab56180 reacts with Matripase 2 (TMPRSS6) and does not react with the other TMPRSSs. ab56180 recognizes all of the listed forms of Matripase 2.

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Alternative Products

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 2.9% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Stable for 12 months at -20°C
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Membrane-bound serine protease (PubMed : 18976966, PubMed : 20518742, PubMed : 25156943, PubMed : 25588876). Through the cleavage of cell surface hemojuvelin (HJV), a regulator of the expression of the iron absorption-regulating hormone hepicidin/HAMP, plays a role in iron homeostasis (PubMed : 18408718, PubMed : 18976966, PubMed : 25156943).
See full target information TMPRSS6
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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 23: PubMed35163229

2022

SEC23B Loss-of-Function Suppresses Hepcidin Expression by Impairing Glycosylation Pathway in Human Hepatic Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Barbara Eleni Rosato,Roberta Marra,Vanessa D'Onofrio,Federica Del Giudice,Simone Della Monica,Achille Iolascon,Immacolata Andolfo,Roberta Russo

Cells 10: PubMed34571900

2021

HCV-Induced Immunometabolic Crosstalk in a Triple-Cell Co-Culture Model Capable of Simulating Systemic Iron Homeostasis.

Applications

Unspecified application

Species

Unspecified reactive species

Pelagia Foka,Alexios Dimitriadis,Eirini Karamichali,Emmanouil Kochlios,Petros Eliadis,Vaia Valiakou,John Koskinas,Avgi Mamalaki,Urania Georgopoulou

FEBS open bio 11:237-250 PubMed33247551

2020

The Hepatitis C virus NS5A and core proteins exert antagonistic effects on HAMP gene expression: the hidden interplay with the MTF-1/MRE pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Alexios Dimitriadis,Pelagia Foka,Eleni Kyratzopoulou,Eirini Karamichali,Stavroula Petroulia,Panagiota Tsitoura,Athanasios Kakkanas,Petros Eliadis,Urania Georgopoulou,Avgi Mamalaki

The Journal of biological chemistry 291:20387-401 PubMed27502273

2016

The Human Ether-a-go-go-related Gene (hERG) Potassium Channel Represents an Unusual Target for Protease-mediated Damage.

Applications

Unspecified application

Species

Unspecified reactive species

Shawn M Lamothe,Jun Guo,Wentao Li,Tonghua Yang,Shetuan Zhang

Cellular and molecular life sciences : CMLS 71:4243-58 PubMed24718935

2014

A complex signaling network involving protein kinase CK2 is required for hepatitis C virus core protein-mediated modulation of the iron-regulatory hepcidin gene expression.

Applications

WB

Species

Unspecified reactive species

Pelagia Foka,Alexios Dimitriadis,Eleni Kyratzopoulou,Dionysios A Giannimaras,Stefania Sarno,George Simos,Urania Georgopoulou,Avgi Mamalaki

The Journal of biological chemistry 286:4090-7 PubMed20966077

2010

Regulation of type II transmembrane serine proteinase TMPRSS6 by hypoxia-inducible factors: new link between hypoxia signaling and iron homeostasis.

Applications

WB

Species

Human

Samira Lakhal,Johannes Schödel,Alain R M Townsend,Christopher W Pugh,Peter J Ratcliffe,David R Mole
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
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