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AB89825

Anti-MAVS antibody

4

(1 Review)

|

(6 Publications)

Mouse Polyclonal MAVS antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human MAVS.

View Alternative Names

IPS1, KIAA1271, VISA, MAVS, Mitochondrial antiviral-signaling protein, CARD adapter inducing interferon beta, Interferon beta promoter stimulator protein 1, Putative NF-kappa-B-activating protein 031N, Virus-induced-signaling adapter, Cardif, IPS-1

1 Images
Western blot - Anti-MAVS antibody (AB89825)
  • WB

Unknown

Western blot - Anti-MAVS antibody (AB89825)

All lanes:

Western blot - Anti-MAVS antibody (ab89825) at 1 µg/mL

All lanes:

Human placenta tissue lysate at 50 µg

Predicted band size: 57 kDa

Observed band size: ~57 kDa

true

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human MAVS.

Q7Z434

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MAVS antibody - N-terminal (AB189303)

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MAVS antibody (AB189109)

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MAVS antibody (AB264147)

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Primary Antibodies

AB40676

Anti-NAK/TBK1 antibody [EP611Y]

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MAVS also known as mitochondrial antiviral-signaling protein is a critical adaptor protein involved in the innate immune response to viral infections. This protein with a molecular weight of approximately 56 kDa is expressed on the mitochondrial membrane. It plays a major role in antiviral defense by transmitting signals from cytosolic pattern recognition receptors like RIG-I-like receptors to initiate downstream immune responses. MAVS can also be referred to as IPS-1 VISA or CARDIF in scientific literature.
Biological function summary

The MAVS protein activates important signaling cascades to produce type I interferons and other cytokines which are essential in the antiviral response. MAVS forms a complex with other proteins on the mitochondrial membrane helping to coordinate a rapid immune reaction to viral pathogens. It acts by amplifying the signal from RIG-I and MDA5 facilitating their role in the recognition of viral RNA. By recruiting downstream signaling molecules MAVS enables the activation of transcription factors like IRF3 and NF-kB.

Pathways

MAVS plays a central role in the signaling pathways that regulate innate immunity including the RIG-I-like receptor signaling pathway and the NF-kB pathway. It interacts with various proteins such as TRIF and STING in the pathways to modulate immune responses. These pathways help trigger the production of antiviral substances and maintain homeostasis within the body's defense mechanisms. MAVS provides a platform for the assembly of signaling complexes which are necessary for the propagation and amplification of the immune response signal.

MAVS is associated with conditions such as viral infections and autoimmune diseases. Dysregulation of MAVS activity has been linked to systemic lupus erythematosus where abnormal immune signaling may occur. MAVS also has connections with other proteins such as TRAF3 and TRAF6 which contribute to disease pathogenesis. Understanding the role of MAVS in these conditions may provide insights into therapeutic targets for improving disease outcomes.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Adapter required for innate immune defense against viruses (PubMed : 16125763, PubMed : 16127453, PubMed : 16153868, PubMed : 16177806, PubMed : 19631370, PubMed : 20127681, PubMed : 20451243, PubMed : 21170385, PubMed : 23087404, PubMed : 27992402, PubMed : 33139700, PubMed : 37582970). Acts downstream of DHX33, RIGI and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFNB and RANTES (CCL5) (PubMed : 16125763, PubMed : 16127453, PubMed : 16153868, PubMed : 16177806, PubMed : 19631370, PubMed : 20127681, PubMed : 20451243, PubMed : 20628368, PubMed : 21170385, PubMed : 23087404, PubMed : 25636800, PubMed : 27736772, PubMed : 33110251). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (PubMed : 20451243). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (PubMed : 20451243). May activate the same pathways following detection of extracellular dsRNA by TLR3 (PubMed : 16153868). May protect cells from apoptosis (PubMed : 16125763). Involved in NLRP3 inflammasome activation by mediating NLRP3 recruitment to mitochondria (PubMed : 23582325).
See full target information MAVS
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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

Cancer research communications 5:358-368 PubMed39895413

2025

Phase Ib Study of Immunocytokine Simlukafusp Alfa (FAP-IL2v) Combined with Pembrolizumab for Treatment of Advanced and/or Metastatic Melanoma.

Applications

Unspecified application

Species

Unspecified reactive species

Eva Munoz-Couselo,Ainara Soria Rivas,Shahneen Sandhu,Georgina V Long,Miguel F Sanmamed,Anna Spreafico,Elizabeth Buchbinder,Mario Sznol,Hans Prenen,Alexander Fedenko,Mohammed Milhem,Ana Maria Arance Fernandez,Jean-Jacques Grob,Lev Demidov,Caroline Robert,Christin Habigt,Stefan Evers,Nassim Sleiman,David Dejardin,Caroline Ardeshir,Nicole Martin,Christophe Boetsch,Jehad Charo,Volker Teichgräber,Anton Kraxner,Nino Keshelava,Oliver Bechter

Nature communications 15:9321 PubMed39472584

2024

Inhibiting EZH2 targets atypical teratoid rhabdoid tumor by triggering viral mimicry via both RNA and DNA sensing pathways.

Applications

Unspecified application

Species

Unspecified reactive species

Shengrui Feng,Sajid A Marhon,Dustin J Sokolowski,Alister D'Costa,Fraser Soares,Parinaz Mehdipour,Charles Ishak,Helen Loo Yau,Ilias Ettayebi,Parasvi S Patel,Raymond Chen,Jiming Liu,Philip C Zuzarte,King Ching Ho,Ben Ho,Shiyao Ning,Annie Huang,Cheryl H Arrowsmith,Michael D Wilson,Jared T Simpson,Daniel D De Carvalho

Nature genetics 56:1890-1902 PubMed39227744

2024

In vivo CRISPR screens identify a dual function of MEN1 in regulating tumor-microenvironment interactions.

Applications

Unspecified application

Species

Unspecified reactive species

Peiran Su,Yin Liu,Tianyi Chen,Yibo Xue,Yong Zeng,Guanghui Zhu,Sujun Chen,Mona Teng,Xinpei Ci,Mengdi Guo,Michael Y He,Jun Hao,Vivian Chu,Wenxi Xu,Shiyan Wang,Parinaz Mehdipour,Xin Xu,Sajid A Marhon,Fraser Soares,Nhu-An Pham,Bell Xi Wu,Peter Hyunwuk Her,Shengrui Feng,Najd Alshamlan,Maryam Khalil,Rehna Krishnan,Fangyou Yu,Chang Chen,Francis Burrows,Razqallah Hakem,Mathieu Lupien,Shane Harding,Benjamin H Lok,Catherine O'Brien,Alejandro Berlin,Daniel D De Carvalho,David G Brooks,Daniel Schramek,Ming-Sound Tsao,Housheng Hansen He

Cell reports 43:113684 PubMed38261511

2024

Retroelement decay by the exonuclease XRN1 is a viral mimicry dependency in cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Amir Hosseini,Håvard T Lindholm,Raymond Chen,Parinaz Mehdipour,Sajid A Marhon,Charles A Ishak,Paul C Moore,Marie Classon,Andrea Di Gioacchino,Benjamin Greenbaum,Daniel D De Carvalho

Journal of virology 96:e0072322 PubMed35975999

2022

Evidence against the Human Metapneumovirus G, SH, and M2-2 Proteins as Bona Fide Interferon Antagonists.

Applications

Unspecified application

Species

Unspecified reactive species

K Groen,S van Nieuwkoop,M M Lamers,R A M Fouchier,B G van den Hoogen

The Journal of biological chemistry 297:101277 PubMed34619148

2021

Modulation of SF3B1 in the pre-mRNA spliceosome induces a RIG-I-dependent type I IFN response.

Applications

Unspecified application

Species

Unspecified reactive species

Aaron Y Chang,Yu Jerry Zhou,Sharanya Iyengar,Piotr W Pobiarzyn,Pavel Tishchenko,Kesha M Shah,Heather Wheeler,Yue-Ming Wang,Paula M Loria,Frank Loganzo,Seng-Ryong Woo
View all publications
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