Anti-MBNL3 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Muscleblind-like protein 3 (MBNL3) mechanically plays a role in RNA splicing and localization. It lacks a popular alternate name in scientific literature. MBNL3 has a mass of 36 kDa and is expressed widely in human tissues with higher expression in skeletal muscle heart and brain. The protein binds RNA via its zinc-finger domains enabling it to influence the processing of pre-mRNA transcripts.

Biological function summary

In the regulation of gene expression networks MBNL3 modulates alternative splicing and RNA stability. Though not part of a larger multiprotein complex it interacts directly with precursor mRNA specifically affecting splicing events. This regulation is critical in maintaining normal tissue function and development particularly in muscle and neural tissues.

Pathways

MBNL3 impacts RNA processing and stress response pathways. MBNL3 interacts with its homologs MBNL1 and MBNL2 which are part of the same splicing regulatory network. Through these interactions it affects pathways involved in cell differentiation and response to environmental stress contributing to the regulation of gene expression under varying physiological conditions.

Associated diseases and disorders

Defects in MBNL3 function are associated with myotonic dystrophy and certain cancers. In myotonic dystrophy imbalanced splicing caused by malfunction of MBNL proteins including MBNL3 leads to muscular and neurological symptoms. In cancers changes in the expression or activity of MBNL3 might influence tumor progression through its role in splicing regulation. Understanding the connection between MBNL3 and diseases can inform therapeutic target research and potential treatment strategies.