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AB140864

Anti-MC3-R antibody

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(2 Publications)

Rabbit Polyclonal MC3-R antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human MC3R.

View Alternative Names

Melanocortin receptor 3, MC3-R, MC3R

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MC3-R antibody (AB140864)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MC3-R antibody (AB140864)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human brain cortex tissue labelling MC3-R with ab140864 at 10 μg/ml.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human MC3R. The exact immunogen used to generate this antibody is proprietary information.

P41968

Specificity

BLAST analysis of the peptide immunogen showed no homology with other Human proteins, except MC5R (78%).

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Alternative Products

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "10-12 µg/mL", "IHCP-species-notes": "<p>Immunohistochemistry with formalin-fixed paraffin-embedded tissues requires pretreatment with Proteinase K.</p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Dog": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Elephant": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Hamster": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Horse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Pig": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MC3-R also known as melanocortin 3 receptor is a member of the melanocortin receptor family. It functions as a G-protein-coupled receptor with a mass of approximately 35 kDa. MC3-R is expressed mainly in the hypothalamus and pituitary gland with lower expression seen in other regions of the brain and peripheral tissues. It binds to several peptide hormones including alpha- beta- and gamma-melanocyte-stimulating hormones (MSH) and adrenocorticotropic hormone (ACTH).
Biological function summary

MC3-R serves roles in controlling energy homeostasis and inflammatory responses. This receptor is not part of a complex but it contributes to several physiological processes such as modulation of fat storage and glucose metabolism. It influences feeding behavior and energy expenditure by acting on specific neuropeptides. Its activity links to several neuroendocrine functions as well.

Pathways

MC3-R integrates into the central melanocortin system which involves the regulation of energy balance. It operates alongside other melanocortin receptors such as MC4-R to mediate appetite and body weight management. The receptor also participates in the regulation of the hypothalamic-pituitary-adrenal (HPA) axis interacting with proteins like pro-opiomelanocortin (POMC) and Agouti-related peptide (AgRP) in its pathways.

MC3-R connects to obesity and metabolic syndrome. Disruptions in its signaling can lead to abnormal energy balance and weight gain. This receptor also relates to inflammatory diseases as dysregulation of its pathways may contribute to chronic inflammatory conditions. MC4-R and POMC are among the proteins that associate with MC3-R in these disorders reflecting its role in complex physiological and pathological processes.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

G protein-coupled receptor for melanocyte-stimulating hormones (alpha, beta, and gamma-MSH) and corticotropin/ACTH, which are peptide products of the POMC precursor (PubMed : 37524700, PubMed : 8463333). Upon activation, couples to G(s) protein, stimulating adenylate cyclase and the cAMP-dependent signaling pathway, which contributes to the regulation of energy homeostasis (PubMed : 18231126, PubMed : 37524700, PubMed : 8463333). Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain (By similarity). Binding of the Agouti-related protein/AGPR antagonist precludes alpha-MSH-induced signaling, blocking cAMP production (PubMed : 9311920).
See full target information MC3R
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

World journal of gastroenterology 30:1132-1142 PubMed38577176

2024

Melanocortin 3,5 receptors immunohistochemical expression in colonic mucosa of inflammatory bowel disease patients: A matter of disease activity?

Applications

Unspecified application

Species

Unspecified reactive species

Antonietta Gerarda Gravina,Iacopo Panarese,Maria Consiglia Trotta,Michele D'Amico,Raffaele Pellegrino,Franca Ferraraccio,Marilena Galdiero,Roberto Alfano,Paolo Grieco,Alessandro Federico

PloS one 10:e0117581 PubMed25807145

2015

Discovery of molecular markers to discriminate corneal endothelial cells in the human body.

Applications

Unspecified application

Species

Unspecified reactive species

Masahito Yoshihara,Hiroko Ohmiya,Susumu Hara,Satoshi Kawasaki,Yoshihide Hayashizaki,Masayoshi Itoh,Hideya Kawaji,Motokazu Tsujikawa,Kohji Nishida
View all publications
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Product promise

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