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AB121447

Anti-MCEMP1 antibody

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(2 Publications)

Rabbit Polyclonal MCEMP1 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MCEMP1 aa 100-200.

View Alternative Names

C19orf59, MCEMP1, Mast cell-expressed membrane protein 1

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MCEMP1 antibody (AB121447)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MCEMP1 antibody (AB121447)

ab121447, at 1/150 dilution, staining MCEMP1 in paraffin-embedded Human bone marrow tissue by Immunohistochemistry, showing strong cytoplasmic positivity in bone marrow poietic cells.

Western blot - Anti-MCEMP1 antibody (AB121447)
  • WB

Unknown

Western blot - Anti-MCEMP1 antibody (AB121447)

All lanes:

Western blot - Anti-MCEMP1 antibody (ab121447) at 1/250 dilution

Lane 1:

Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10

Lane 2:

Negative control (vector only transfected HEK293T lysate)

Lane 3:

Over-expression Lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells)

Predicted band size: 21 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human MCEMP1 aa 100-200. The exact immunogen used to generate this antibody is proprietary information.

Q8IX19

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p>Use buffer at pH 6 for antigen retrieval.</p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MCEMP1 also known as Mast Cell Expressed Membrane Protein 1 is a protein that plays an important role in cellular functions. The protein has a molecular mass of approximately 17 kDa. MCEMP1 is mainly expressed on the cell membranes of mast cells which are involved in immune system responses. This expression pattern suggests MCEMP1's involvement in processes closely tied to mast cell biology.
Biological function summary

This protein has significant roles in mast cell activation and signal transduction. MCEMP1 is not part of a known protein complex but it influences mast cell degranulation where cells release histamine and other mediators. This activity places MCEMP1 as an influential protein impacting the body's response to allergens and infections.

Pathways

MCEMP1 is important for pathways related to immune system signaling and allergic responses. In the immune signaling pathway MCEMP1 impacts mast cell mediator release interacting with proteins such as FcεRI a high-affinity receptor for IgE. Another related pathway involves inflammatory responses where MCEMP1 further regulates signals that contribute to the body's defense mechanism against pathogens.

MCEMP1 is linked to allergic reactions and asthma. These conditions often result from excessive activation of mast cells where MCEMP1 plays a regulatory function. The protein interacts closely with FcεRI in asthma a chronic condition characterized by airway inflammation. Understanding the role of MCEMP1 in these disorders helps in exploring potential therapeutic targets for managing allergic conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information MCEMP1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in physiology 12:714785 PubMed34408668

2021

Upregulation of Calcium Homeostasis Modulators in Contractile-To-Proliferative Phenotypical Transition of Pulmonary Arterial Smooth Muscle Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Marisela Rodriguez,Jiyuan Chen,Pritesh P Jain,Aleksandra Babicheva,Mingmei Xiong,Jifeng Li,Ning Lai,Tengteng Zhao,Moises Hernandez,Angela Balistrieri,Sophia Parmisano,Tatum Simonson,Ellen Breen,Daniela Valdez-Jasso,Patricia A Thistlethwaite,John Y-J Shyy,Jian Wang,Joe G N Garcia,Ayako Makino,Jason X-J Yuan

IUBMB life 71:956-968 PubMed30883005

2019

Silence of long noncoding RNA NEAT1 exerts suppressive effects on immunity during sepsis by promoting microRNA-125-dependent MCEMP1 downregulation.

Applications

Unspecified application

Species

Unspecified reactive species

Jian-Xin Chen,Xiong Xu,Sen Zhang
View all publications
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Product promise

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