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AB188572

Anti-MCEMP1 antibody [EPR14393] - C-terminal

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(3 Publications)

Rabbit Recombinant Monoclonal MCEMP1 antibody. C-terminal. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications.

View Alternative Names

C19orf59, MCEMP1, Mast cell-expressed membrane protein 1

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MCEMP1 antibody [EPR14393] - C-terminal (AB188572)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MCEMP1 antibody [EPR14393] - C-terminal (AB188572)

Immunohistochemical analysis of paraffin-embedded Human lung tissue labeling MCEMP1 with ab188572 at 1/100. A prediluted HRP Polymer for Rabbit IgG was used as the secondary antibody.

Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.

Western blot - Anti-MCEMP1 antibody [EPR14393] - C-terminal (AB188572)
  • WB

Supplier Data

Western blot - Anti-MCEMP1 antibody [EPR14393] - C-terminal (AB188572)

All lanes:

Western blot - Anti-MCEMP1 antibody [EPR14393] - C-terminal (ab188572) at 1/1000 dilution

All lanes:

THP-1 lysate at 20 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Predicted band size: 21 kDa

Observed band size: 21 kDa

false

  • Carrier free

    Anti-MCEMP1 antibody [EPR14393] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR14393

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/100", "IHCP-species-notes": "<p></p>" } } }
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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MCEMP1 also known as Mast Cell Expressed Membrane Protein 1 is a protein that plays an important role in cellular functions. The protein has a molecular mass of approximately 17 kDa. MCEMP1 is mainly expressed on the cell membranes of mast cells which are involved in immune system responses. This expression pattern suggests MCEMP1's involvement in processes closely tied to mast cell biology.
Biological function summary

This protein has significant roles in mast cell activation and signal transduction. MCEMP1 is not part of a known protein complex but it influences mast cell degranulation where cells release histamine and other mediators. This activity places MCEMP1 as an influential protein impacting the body's response to allergens and infections.

Pathways

MCEMP1 is important for pathways related to immune system signaling and allergic responses. In the immune signaling pathway MCEMP1 impacts mast cell mediator release interacting with proteins such as FcεRI a high-affinity receptor for IgE. Another related pathway involves inflammatory responses where MCEMP1 further regulates signals that contribute to the body's defense mechanism against pathogens.

MCEMP1 is linked to allergic reactions and asthma. These conditions often result from excessive activation of mast cells where MCEMP1 plays a regulatory function. The protein interacts closely with FcεRI in asthma a chronic condition characterized by airway inflammation. Understanding the role of MCEMP1 in these disorders helps in exploring potential therapeutic targets for managing allergic conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information MCEMP1
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Haematologica 110:1339-1350 PubMed39665214

2024

Characterization of tumor microenvironment and cell interaction patterns in testicular and diffuse large B-cell lymphomas.

Applications

Unspecified application

Species

Unspecified reactive species

Matias Autio,Oscar Brück,Marjukka Pollari,Marja-Liisa Karjalainen-Lindsberg,Klaus Beiske,Judit Mészaros Jørgensen,Harald Holte,Teijo Pellinen,Suvi-Katri Leivonen,Sirpa Leppä

Journal of oncology 2022:8167496 PubMed35378772

2022

The Expression, Prognostic Value, and Immunological Correlation of MCEMP1 and its Potential Role in Gastric Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Pu Huang,Yawen Liu,Baoqing Jia

Journal of cellular biochemistry 120:16786-16797 PubMed31104315

2019

Lentiviral-mediated silencing of mast cell-expressed membrane protein 1 promotes angiogenesis of rats with cerebral ischemic stroke.

Applications

Unspecified application

Species

Unspecified reactive species

Rui Jian,Min Yang,Fangyuan Xu
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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