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BiochemicalsProteins and Peptides
Proteins and peptidesAnti-Ly6g antibody [1A8] - mouse IgG2c (Chimeric)
Low endotoxin, Azide free.
Our first-to-market chimera with mouse IgG2c backbone, this functional antibody specifically depletes neutrophils in vivo for up to 72h.
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Rabbit Polyclonal MCHR-1 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human MCHR1 conjugated to Keyhole Limpet Haemocyanin.
IgG
Rabbit
pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 99% PBS
Liquid
Polyclonal
IHC-P | |
---|---|
Human | Tested |
Mouse | Predicted |
Rat | Predicted |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 10.00000-18.00000 µg/mL | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Species | Dilution info | Notes |
---|---|---|
Species Mouse, Rat | Dilution info - | Notes - |
Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis.
Melanin-concentrating hormone receptor 1, MCH receptor 1, MCH-R1, MCHR-1, G-protein coupled receptor 24, MCH-1R, SLC-1, Somatostatin receptor-like protein, MCH1R, MCHR, SLC1, GPR24, MCHR1
Rabbit Polyclonal MCHR-1 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human MCHR1 conjugated to Keyhole Limpet Haemocyanin.
Melanin-concentrating hormone receptor 1, MCH receptor 1, MCH-R1, MCHR-1, G-protein coupled receptor 24, MCH-1R, SLC-1, Somatostatin receptor-like protein, MCH1R, MCHR, SLC1, GPR24, MCHR1
IgG
Rabbit
pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 99% PBS
Liquid
Polyclonal
Affinity purification Protein A
Blue Ice
-80°C
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
MCHR-1 involves regulation of energy homeostasis and feeding behavior. It does not function as part of a larger protein complex but operates primarily by binding MCH which modulates neurotransmitter activity. This interaction affects neural circuits controlling body weight and food intake. Additionally MCHR-1 participates in processes related to the reward system and stress response.
MCHR-1 also known as melanin-concentrating hormone receptor 1 is a G protein-coupled receptor that binds the melanin-concentrating hormone (MCH). This receptor has a molecular mass of approximately 45 kDa. MCHR-1 is expressed in several areas of the brain including the hypothalamus olfactory bulb and cerebral cortex. It also appears in peripheral tissues such as the gastrointestinal tract and kidneys.
MCHR-1 plays an essential role in melanin-concentrating hormone signaling pathway which directly impacts the hypothalamic regulation of appetite and energy expenditure. It therefore connects with proteins like orexin which also influence energy balance and arousal states. Moreover this receptor is involved in intracellular signaling pathways through G proteins affecting cyclic AMP levels and calcium mobilization.
MCHR-1 associates with obesity and depression. Dysregulation of MCHR-1 activity can lead to changes in body weight and metabolic issues making it a potential target for anti-obesity drugs. Additionally the receptor has links to depressive disorders as imbalance in MCH signaling can influence mood and stress response. In this context MCHR-1 activity intersects with serotonin systems in the brain which are important in mood regulation.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
ab115474 at 10-18ug/ml staining MCHR-1 in Formalin-fixed, Paraffin-embedded Human brain (substantia nigra) tissue by Immunohistochemistry, followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
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