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AB9737

Anti-MCP5 antibody

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(1 Publication)

Rabbit Polyclonal MCP5 antibody. Suitable for ELISA, WB, sELISA and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Mouse Ccl12.

View Alternative Names

Mcp5, Scya12, Ccl12, C-C motif chemokine 12, MCP-1-related chemokine, Monocyte chemoattractant protein 5, Monocyte chemotactic protein 5, Small-inducible cytokine A12, MCP-5

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

Unknown

Light chain type

unknown

Carrier free

No

Reacts with

Mouse

Applications

ELISA, sELISA, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Mouse Ccl12.

Q62401

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Complementary Products

Assay Kits

AB246547

Mouse MCP-5 ELISA Kit

Recombinant|SimpleStep

Sandwich ELISA - Mouse MCP-5 ELISA Kit (AB246547)

  • 0
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Primary Antibodies

AB199043

Anti-CXCL13 antibody [EPR19259-147]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CXCL13 antibody [EPR19259-147] (AB199043)

  • 5
  • 2
Primary Antibodies

AB179638

Anti-CCL3 / MIP-1 alpha antibody [EPR16618-90]

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-CCL3 / MIP-1 alpha antibody [EPR16618-90] (AB179638)

  • 0
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Primary Antibodies

AB315478

Anti-MCP1 antibody [RM1100]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MCP1 antibody [RM1100] (AB315478)

  • 0
  • 0
Primary Antibodies

AB259618

Anti-MMP12 antibody [EPR22132-32] - BSA and Azide free (Detector)

RabMAb|Recombinant

Sandwich ELISA - Anti-MMP12 antibody [EPR22132-32] - BSA and Azide free (Detector) (AB259618)

  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "sELISA-species-checked": "guaranteed", "sELISA-species-dilution-info": "", "sELISA-species-notes": "<p>To detect mMCP-5 by sandwich ELISA (using 100 ul/well antibody solution) a concentration of 0.5 - 2.0 ug/ml of this antibody is required.</p>" } } }
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Properties and storage information

Form
Lyophilized
Reconstitution
Reconstitute with 200µl of sterile water.
Purification technique
Affinity purification Immunogen
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MCP-5 also known as CCL12 is a chemokine protein that plays a role in immune response by recruiting and activating leukocytes. It has a molecular mass of approximately 12 kDa. This protein is expressed mainly in tissues related to the immune system including the spleen and liver. MCP-5 exhibits a sequence homology with other members of the C-C chemokine family and shares functional similarities with MCP-1.
Biological function summary

MCP-5 takes part in promoting the migration of monocytes and lymphocytes to sites of inflammation. This chemokine is not a part of a complex but interacts with specific receptors on target cells such as CCR2. Through these interactions MCP-5 helps mediate a range of immune responses enhancing both innate and adaptive immune activities. It also contributes to the clearance of pathogens by guiding leukocytes to infection sites.

Pathways

MCP-5 plays an important role in the chemokine signaling pathway and the inflammatory response pathway. Through chemokine signaling MCP-5 interacts with CCR2 facilitating the movement of immune cells to areas of tissue damage or infection. This regulation of cell traffic is essential for maintaining homeostasis and responding to pathological changes in tissues. Another protein connected to MCP-5 in these pathways is MCP-3 which shares overlapping functions in immune cell recruitment.

MCP-5 has been implicated in conditions such as asthma and rheumatoid arthritis. In these disorders MCP-5 contributes to the recruitment of inflammatory cells worsening symptoms. It also shows a connection with other proteins like MCP-1 which similarly aids in the movement of monocytes to inflammatory sites. The presence and activity of MCP-5 and its related proteins can therefore represent potential targets for therapeutic interventions in controlling excessive inflammatory responses.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Chemotactic factor that attracts eosinophils, monocytes, and lymphocytes but not neutrophils. Potent monocyte active chemokine that signals through CCR2. Involved in allergic inflammation and the host response to pathogens and may play a pivotal role during early stages of allergic lung inflammation.
See full target information Ccl12
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in microbiology 9:3075 PubMed30622516

2019

A New Bifidobacteria Expression SysTem (BEST) to Produce and Deliver Interleukin-10 in .

Applications

Unspecified application

Species

Unspecified reactive species

Aurélie Mauras,Florian Chain,Aurélie Faucheux,Pauline Ruffié,Sophie Gontier,Bernhard Ryffel,Marie-José Butel,Philippe Langella,Luis G Bermúdez-Humarán,Anne-Judith Waligora-Dupriet
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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