Rabbit Polyclonal MCT 10 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SLC16A10 aa 450 to C-terminus.
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- Frontiers in neuroscience 9:1232015Influx mechanisms in the embryonic and adult rat choroid plexus: a transcriptome study.Applications:Unspecified applicationReactive species:Unspecified reactive speciesNorman R Saunders et. al.PubMed 25972776
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human SLC16A10 aa 450 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q8TF71
Reactivity data
Select an application| IHC-P | ICC/IF | |
|---|---|---|
| Human | Tested | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info - | Notes - |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 0.20000-0.25000 µg/mL | Notes - |
Target data
Function
Sodium- and proton-independent thyroid hormones and aromatic acids transporter (PubMed:11827462, PubMed:18337592, PubMed:28754537). Mediates both uptake and efflux of 3,5,3'-triiodothyronine (T3) and 3,5,3',5'-tetraiodothyronine (T4) with high affinity, suggesting a role in the homeostasis of thyroid hormone levels (PubMed:18337592). Responsible for low affinity bidirectional transport of the aromatic amino acids, such as phenylalanine, tyrosine, tryptophan and L-3,4-dihydroxyphenylalanine (L-dopa) (PubMed:11827462, PubMed:28754537). Plays an important role in homeostasis of aromatic amino acids (By similarity).
Alternative names
MCT10, TAT1, SLC16A10, Monocarboxylate transporter 10, MCT 10, Aromatic amino acid transporter 1, Solute carrier family 16 member 10, T-type amino acid transporter 1
Recommended products
Rabbit Polyclonal MCT 10 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SLC16A10 aa 450 to C-terminus.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human SLC16A10 aa 450 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q8TF71
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
MCT 10 also known as SLC16A10 is a member of the monocarboxylate transporter family. This transporter protein has a mass of approximately 58 kDa and facilitates the transport of aromatic amino acids across cell membranes. MCT 10 is mainly expressed in tissues like the small intestine liver kidney and placenta. It functions as a sodium-independent transporter which distinguishes it from other amino acid transporters that may rely on sodium gradients.
- Biological function summary
MCT 10 plays a significant role in the cellular uptake and export of aromatic amino acids like tryptophan phenylalanine and tyrosine. These amino acids are essential precursors for the synthesis of important biological compounds. MCT 10 is not part of a larger protein complex but operates individually to facilitate these transport processes. Its function provides cells with necessary aromatic amino acids for various metabolic pathways and supports the body's metabolic needs.
- Pathways
MCT 10 is a critical component in amino acid transport and metabolism. It is closely linked with pathways involving protein synthesis and neurotransmitter production. The transport activity of MCT 10 influences the concentration of precursor molecules for synthesis of proteins and neurotransmitters. MCT 10 works alongside other transporter proteins such as LAT1 within these metabolic pathways to ensure efficient cellular function and communication.
- Associated diseases and disorders
Impaired function of MCT 10 has been associated with certain inherited disorders of amino acid metabolism. These disorders can alter the normal balance of amino acids leading to metabolic complications. Aberrations in MCT 10 expression or function may also have implications in metabolic diseases and could affect related proteins like LAT1 which share similar transport duties and substrate specificities. Research on MCT 10 may unveil new insights into therapeutic targets for addressing disorders of amino acid metabolism.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Immunocytochemistry/ Immunofluorescence - Anti-MCT 10 antibody (ab121519)
Immunofluorescent staining of MCT 10 using ab121519 at 2 μg/ml in human cell line CACO-2
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MCT 10 antibody (ab121519)
ab121519 at 1/10 dilution staining MCT 10 in Paraffin-embedded Human Skeletal muscle tissue by Immunohistochemistry.
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