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AB121519

Anti-MCT 10 antibody

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(2 Publications)

Rabbit Polyclonal MCT 10 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SLC16A10 aa 450 to C-terminus.

View Alternative Names

MCT10, TAT1, SLC16A10, Monocarboxylate transporter 10, MCT 10, Aromatic amino acid transporter 1, Solute carrier family 16 member 10, T-type amino acid transporter 1

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-MCT 10 antibody (AB121519)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-MCT 10 antibody (AB121519)

Immunofluorescent staining of MCT 10 using ab121519 at 2 μg/ml in human cell line CACO-2

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MCT 10 antibody (AB121519)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MCT 10 antibody (AB121519)

ab121519 at 1/10 dilution staining MCT 10 in Paraffin-embedded Human Skeletal muscle tissue by Immunohistochemistry.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human SLC16A10 aa 450 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q8TF71

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.2-0.25 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MCT 10 also known as SLC16A10 is a member of the monocarboxylate transporter family. This transporter protein has a mass of approximately 58 kDa and facilitates the transport of aromatic amino acids across cell membranes. MCT 10 is mainly expressed in tissues like the small intestine liver kidney and placenta. It functions as a sodium-independent transporter which distinguishes it from other amino acid transporters that may rely on sodium gradients.
Biological function summary

MCT 10 plays a significant role in the cellular uptake and export of aromatic amino acids like tryptophan phenylalanine and tyrosine. These amino acids are essential precursors for the synthesis of important biological compounds. MCT 10 is not part of a larger protein complex but operates individually to facilitate these transport processes. Its function provides cells with necessary aromatic amino acids for various metabolic pathways and supports the body's metabolic needs.

Pathways

MCT 10 is a critical component in amino acid transport and metabolism. It is closely linked with pathways involving protein synthesis and neurotransmitter production. The transport activity of MCT 10 influences the concentration of precursor molecules for synthesis of proteins and neurotransmitters. MCT 10 works alongside other transporter proteins such as LAT1 within these metabolic pathways to ensure efficient cellular function and communication.

Impaired function of MCT 10 has been associated with certain inherited disorders of amino acid metabolism. These disorders can alter the normal balance of amino acids leading to metabolic complications. Aberrations in MCT 10 expression or function may also have implications in metabolic diseases and could affect related proteins like LAT1 which share similar transport duties and substrate specificities. Research on MCT 10 may unveil new insights into therapeutic targets for addressing disorders of amino acid metabolism.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Sodium- and proton-independent thyroid hormones and aromatic acids transporter (PubMed : 11827462, PubMed : 18337592, PubMed : 28754537). Mediates both uptake and efflux of 3,5,3'-triiodothyronine (T3) and 3,5,3',5'-tetraiodothyronine (T4) with high affinity, suggesting a role in the homeostasis of thyroid hormone levels (PubMed : 18337592). Responsible for low affinity bidirectional transport of the aromatic amino acids, such as phenylalanine, tyrosine, tryptophan and L-3,4-dihydroxyphenylalanine (L-dopa) (PubMed : 11827462, PubMed : 28754537). Plays an important role in homeostasis of aromatic amino acids (By similarity).
See full target information SLC16A10
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Journal of experimental & clinical cancer research 38:25 PubMed30658672

2019

DHHC protein family targets different subsets of glioma stem cells in specific niches.

Applications

Unspecified application

Species

Unspecified reactive species

Xueran Chen,Lei Hu,Haoran Yang,Huihui Ma,Kaiqin Ye,Chenggang Zhao,Zhiyang Zhao,Haiming Dai,Hongzhi Wang,Zhiyou Fang

Frontiers in neuroscience 9:123 PubMed25972776

2015

Influx mechanisms in the embryonic and adult rat choroid plexus: a transcriptome study.

Applications

Unspecified application

Species

Unspecified reactive species

Norman R Saunders,Katarzyna M Dziegielewska,Kjeld Møllgård,Mark D Habgood,Matthew J Wakefield,Helen Lindsay,Nathalie Stratzielle,Jean-Francois Ghersi-Egea,Shane A Liddelow
View all publications
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Product promise

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