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AB198243

Anti-MCT 14 antibody - C-terminal

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(1 Publication)

Rabbit Polyclonal MCT 14 antibody. C-terminal. Suitable for WB and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human SLC16A14.

View Alternative Names

MCT14, SLC16A14, Monocarboxylate transporter 14, MCT 14, Solute carrier family 16 member 14

1 Images
Western blot - Anti-MCT 14 antibody - C-terminal (AB198243)
  • WB

Supplier Data

Western blot - Anti-MCT 14 antibody - C-terminal (AB198243)

10%SDS-PAGE

All lanes:

Western blot - Anti-MCT 14 antibody - C-terminal (ab198243) at 1/300 dilution

All lanes:

mouse kidney tissue lysate at 40 µg

Predicted band size: 56 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

WB

applications

Immunogen

Synthetic Peptide within Human SLC16A14. The exact immunogen used to generate this antibody is proprietary information.

Q7RTX9

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/200 - 1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MCT14 also known as Solute Carrier Family 16 Member 14 (SLC16A14) is a monocarboxylate transporter protein. It plays a mechanical role in transporting monocarboxylates such as lactate and pyruvate across cellular membranes. Although the exact mass of MCT14 is not widely characterized its general structure fits within the broader class of monocarboxylate transporters. MCT14 is expressed in several tissues with higher expression levels observed in the brain and kidney which suggests it plays a nuanced role in cellular metabolism.
Biological function summary

MCT14 contributes to cellular energy metabolism by facilitating the movement of essential metabolites across cell membranes. This transporter is not known to be part of a larger protein complex distinguishing its function from other transporters that require complex formation for activity. The metabolic roles performed by MCT14 make it an important player in maintaining cellular homeostasis especially where intermediary metabolism demands efficient solute exchange.

Pathways

MCT14 influences glycolytic and gluconeogenic pathways due to its involvement in lactate transport. This function aligns it with proteins such as MCT1 and MCT4 which also transport similar substrates. Both glycolysis and gluconeogenesis are essential for energy regulation and metabolic balance within cells especially in tissues with high metabolic activity like the brain.

Research associates MCT14 with metabolic disorders such as diabetes where lactate transport may influence disease progression. The role of MCT14 in transporting pyruvate also connects it to some neurological disorders implicating potential disruption in energy metabolism. Proteins like MCT2 which shares similar functions in lactate transport may interact with or regulate MCT14 activity under these disease conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane.
See full target information SLC16A14
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 21: PubMed32887414

2020

MBNL1-Associated Mitochondrial Dysfunction and Apoptosis in C2C12 Myotubes and Mouse Skeletal Muscle.

Applications

Unspecified application

Species

Unspecified reactive species

Shingo Yokoyama,Yoshitaka Ohno,Tatsuro Egawa,Kazuya Ohashi,Rika Ito,Huascar Pedro Ortuste Quiroga,Tomohiro Yamashita,Katsumasa Goto
View all publications
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Product promise

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For full details, please see our Terms & Conditions

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