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Rabbit Polyclonal MCT 8 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human SLC16A2 aa 50-150.


Images

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS, 0.87% Sodium chloride

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Synthetic Peptide within Human SLC16A2 aa 50-150. The exact immunogen used to generate this antibody is proprietary information. Database link P36021
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Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WBIHC-P
Human
Tested
Tested
Mouse
Predicted
Predicted
Rat
Predicted
Predicted

Tested
Tested

Species

Human

Dilution info

1/500.00000 - 1/1000.00000

Notes

-

Predicted
Predicted

Species

Mouse, Rat

Dilution info

-

Notes

-

Tested
Tested

Species

Human

Dilution info

5 µg/mL

Notes

-

Predicted
Predicted

Species

Mouse, Rat

Dilution info

-

Notes

-

Target data

Function

Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr.

Alternative names

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Rabbit Polyclonal MCT 8 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human SLC16A2 aa 50-150.

Alternative names

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Synthetic Peptide within Human SLC16A2 aa 50-150. The exact immunogen used to generate this antibody is proprietary information. Database link P36021
Purification technique

Affinity purification Immunogen

Concentration
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Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

Biological function summary

MCT 8 serves a significant role in maintaining normal thyroid hormone levels within cells affecting development and metabolism. It does not act alone but operates as part of a cooperative network with other transporters and receptors to ensure precise hormonal balance. Its activity impacts processes like energy generation and usage as well as nervous system development. MCT 8's ability to mediate hormone access to target tissues highlights its importance in these biological processes.

Activity summary

MCT 8 also known as monocarboxylate transporter 8 is a protein important for transporting thyroid hormones across cell membranes. This transporter has a mass of approximately 61 kDa. MCT 8 is widely expressed in various tissues including the brain liver and kidneys with a significant presence in neurons. This transporter plays an important mechanical role in hormone regulation by facilitating the cellular uptake and efflux of triiodothyronine (T3) and thyroxine (T4) critical components for proper cellular function.

Pathways

MCT 8 is intricately involved in the thyroid hormone signaling pathway. This pathway influences diverse metabolic and developmental outcomes. MCT 8 works closely with other proteins such as thyroid hormone receptor alpha (THRA) that also bind and respond to thyroid hormones. The synchronization between MCT 8 and these proteins ensures effective communication and function within the hormonal axis impacting metabolic regulation and growth.

Associated diseases and disorders

MCT 8 mutations connect strongly to Allan-Herndon-Dudley syndrome a rare neurodevelopmental disorder. This condition arises from disrupted thyroid hormone transport leading to developmental and cognitive deficiencies. Patients typically exhibit reduced T3 levels in the brain. In this context MCT 8's relationship with proteins like THRA reveals how perturbations in hormone transport can cascade into broader physiological abnormalities.

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2 product images

  • Western blot - Anti-MCT 8 antibody (ab192828), expandable thumbnail

    Western blot - Anti-MCT 8 antibody (ab192828)

    All lanes: Western blot - Anti-MCT 8 antibody (AB192828) at 1/500 dilution

    All lanes: HT29 cell lysate

    Predicted band size: 59 kDa

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MCT 8 antibody (ab192828), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MCT 8 antibody (ab192828)

    Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human adrenal tissue labeling MCT 8 with ab192828 at 5 μg/ml.

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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