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AB192828

Anti-MCT 8 antibody

4

(1 Review)

|

(4 Publications)

Rabbit Polyclonal MCT 8 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human SLC16A2 aa 50-150.

View Alternative Names

MCT7, MCT8, XPCT, SLC16A2, Monocarboxylate transporter 8, MCT 8, Monocarboxylate transporter 7, Solute carrier family 16 member 2, X-linked PEST-containing transporter, MCT 7

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MCT 8 antibody (AB192828)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MCT 8 antibody (AB192828)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human adrenal tissue labeling MCT 8 with ab192828 at 5 μg/ml.

Western blot - Anti-MCT 8 antibody (AB192828)
  • WB

Supplier Data

Western blot - Anti-MCT 8 antibody (AB192828)

All lanes:

Western blot - Anti-MCT 8 antibody (ab192828) at 1/500 dilution

All lanes:

HT29 cell lysate

Predicted band size: 59 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human SLC16A2 aa 50-150. The exact immunogen used to generate this antibody is proprietary information.

P36021

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MCT 8 also known as monocarboxylate transporter 8 is a protein important for transporting thyroid hormones across cell membranes. This transporter has a mass of approximately 61 kDa. MCT 8 is widely expressed in various tissues including the brain liver and kidneys with a significant presence in neurons. This transporter plays an important mechanical role in hormone regulation by facilitating the cellular uptake and efflux of triiodothyronine (T3) and thyroxine (T4) critical components for proper cellular function.
Biological function summary

MCT 8 serves a significant role in maintaining normal thyroid hormone levels within cells affecting development and metabolism. It does not act alone but operates as part of a cooperative network with other transporters and receptors to ensure precise hormonal balance. Its activity impacts processes like energy generation and usage as well as nervous system development. MCT 8's ability to mediate hormone access to target tissues highlights its importance in these biological processes.

Pathways

MCT 8 is intricately involved in the thyroid hormone signaling pathway. This pathway influences diverse metabolic and developmental outcomes. MCT 8 works closely with other proteins such as thyroid hormone receptor alpha (THRA) that also bind and respond to thyroid hormones. The synchronization between MCT 8 and these proteins ensures effective communication and function within the hormonal axis impacting metabolic regulation and growth.

MCT 8 mutations connect strongly to Allan-Herndon-Dudley syndrome a rare neurodevelopmental disorder. This condition arises from disrupted thyroid hormone transport leading to developmental and cognitive deficiencies. Patients typically exhibit reduced T3 levels in the brain. In this context MCT 8's relationship with proteins like THRA reveals how perturbations in hormone transport can cascade into broader physiological abnormalities.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Specific thyroid hormone transmembrane transporter, that mediates both uptake and efflux of thyroid hormones across the cell membrane independently of pH or a Na(+) gradient. Major substrates are the iodothyronines T3 and T4 and to a lesser extent rT3 and 3,3-diiodothyronine (3,3'-T2) (PubMed : 16887882, PubMed : 18337592, PubMed : 20628049, PubMed : 23550058, PubMed : 26426690, PubMed : 27805744, PubMed : 31436139). Acts as an important mediator of thyroid hormone transport, especially T3, through the blood-brain barrier (Probable) (PubMed : 28526555).
See full target information SLC16A2
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Cells 13: PubMed39513900

2024

Thyroid Hormone Supplementation Restores Cognitive Deficit, Insulin Signaling, and Neuroinflammation in the Hippocampus of a Sporadic Alzheimer's-like Disease Rat Model.

Applications

Unspecified application

Species

Unspecified reactive species

Paulina Sepúlveda,Ana Flavia Fernandes Ferreira,Cristian Sandoval,Giovanna Bergoc,Ana Caroline Rippi Moreno,Maria Tereza Nunes,Andréa da Silva Torrão

Nature protocols 19:3162-3190 PubMed39044001

2024

Surface nanocoating of bacteria as a versatile platform to develop living therapeutics.

Applications

Unspecified application

Species

Unspecified reactive species

Zhenping Cao,Jinyao Liu

Frontiers in oncology 13:1077342 PubMed36998462

2023

Development and validation of a combined hypoxia and ferroptosis prognostic signature for breast cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Jianxin Zhong,Xi Shen,Junjie Zhou,Heping Yu,Birong Wang,Jianbin Sun,Jing Wang,Feng Liu

Scientific reports 10:11148 PubMed32636400

2020

CRISRP/Cas9-mediated knockout of Mct8 reveals a functional involvement of Mct8 in testis and sperm development in a rat.

Applications

Unspecified application

Species

Unspecified reactive species

Hee Sook Bae,Yun-Kyeong Jin,Sangwoo Ham,Hee Kyoung Kim,Hyejung Shin,Gyu-Bon Cho,Kyu Jun Lee,Hohyeon Lee,Kyeong-Min Kim,Ok-Jae Koo,Goo Jang,Jung Min Lee,Jae Young Lee
View all publications
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