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AB81262

Anti-MCT2 antibody

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(1 Publication)

Rabbit Polyclonal MCT2 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human SLC16A7.

View Alternative Names

MCT2, SLC16A7, Monocarboxylate transporter 2, MCT 2, Solute carrier family 16 member 7

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human SLC16A7. The exact immunogen used to generate this antibody is proprietary information.

O60669

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Alternative Products

Primary Antibodies

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Primary Antibodies

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Secondary Antibodies

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Primary Antibodies

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Primary Antibodies

AB115730

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Primary Antibodies

AB191071

Anti-Glucose Transporter GLUT3 + GLUT14 antibody [EPR10508(N)] - N-terminal

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "1/400", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
Preservative: 0.08% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MCT2 also known as monocarboxylate transporter 2 or SLC16A7 plays a mechanical role in the transport of monocarboxylates such as lactate pyruvate and ketone bodies across cell membranes. With a molecular mass of approximately 53 kDa MCT2 is expressed in various tissues including the brain liver and skeletal muscles. It is in the plasma membrane where it facilitates the rapid exchange of substrates important for energy metabolism in cells.
Biological function summary

MCT2 facilitates the movement of lactate and other monocarboxylates impacting cellular energy production and homeostasis. It may associate with chaperone proteins like basigin or CD147 which assist in its proper localization in the membrane. This transporter plays a role in metabolic communication between cells reflecting its importance in maintaining high-energy demands especially in neurons and muscle cells.

Pathways

MCT2 has a vital function in glycolysis and oxidative phosphorylation by mediating lactate transport. It participates in the Cori cycle which integrates with glucose metabolism and works alongside lactate dehydrogenase (LDH) to shuttle lactate for gluconeogenesis in the liver. MCT2's operation affects cellular energy balance and tissue responses to metabolic fluctuations.

MCT2 has connections to cancer and neurological disorders such as epilepsy. In cancer altered MCT2 expression affects tumor metabolism and progression interacting with hypoxia-inducible factor-1 (HIF-1) which controls glycolytic enzymes. In neurological conditions deficient or excessive lactate transport by MCT2 could impact neuronal excitability and energy balance potentially linking it to disease-related proteins like glutamate receptors.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Proton-coupled monocarboxylate symporter. Catalyzes the rapid transport across the plasma membrane of monocarboxylates such as L-lactate, pyruvate and ketone bodies, acetoacetate, beta-hydroxybutyrate and acetate (PubMed : 32415067, PubMed : 9786900). Dimerization is functionally required and both subunits work cooperatively in transporting substrate (PubMed : 32415067).
See full target information SLC16A7
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Oncotarget 9:20386-20398 PubMed29755659

2018

The clinicopathological significance of monocarboxylate transporters in testicular germ cell tumors.

Applications

Unspecified application

Species

Unspecified reactive species

Eduardo C A Silva,Flavio M Cárcano,Murilo Bonatelli,Maurício G Zaia,Filipa Morais-Santos,Fátima Baltazar,Luiz F Lopes,Cristovam Scapulatempo-Neto,Céline Pinheiro
View all publications
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Product promise

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