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AB198272

Anti-MCT2 antibody - C-terminal

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(5 Publications)

Rabbit Polyclonal MCT2 antibody. C-terminal. Suitable for WB, IHC-P and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human SLC16A7.

View Alternative Names

MCT2, SLC16A7, Monocarboxylate transporter 2, MCT 2, Solute carrier family 16 member 7

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MCT2 antibody - C-terminal (AB198272)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MCT2 antibody - C-terminal (AB198272)

Immunohistochemical analysis of paraffin-embedded Human ovarian cancer tissue labeling MCT2 with ab198272 at 1/70 dilution.

Western blot - Anti-MCT2 antibody - C-terminal (AB198272)
  • WB

Supplier Data

Western blot - Anti-MCT2 antibody - C-terminal (AB198272)

All lanes:

Western blot - Anti-MCT2 antibody - C-terminal (ab198272) at 1/1200 dilution

All lanes:

A549 cell lysate at 30 µg

Predicted band size: 52 kDa

false

Exposure time: 40s

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human SLC16A7. The exact immunogen used to generate this antibody is proprietary information.

O60669

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MCT2 also known as monocarboxylate transporter 2 or SLC16A7 plays a mechanical role in the transport of monocarboxylates such as lactate pyruvate and ketone bodies across cell membranes. With a molecular mass of approximately 53 kDa MCT2 is expressed in various tissues including the brain liver and skeletal muscles. It is in the plasma membrane where it facilitates the rapid exchange of substrates important for energy metabolism in cells.
Biological function summary

MCT2 facilitates the movement of lactate and other monocarboxylates impacting cellular energy production and homeostasis. It may associate with chaperone proteins like basigin or CD147 which assist in its proper localization in the membrane. This transporter plays a role in metabolic communication between cells reflecting its importance in maintaining high-energy demands especially in neurons and muscle cells.

Pathways

MCT2 has a vital function in glycolysis and oxidative phosphorylation by mediating lactate transport. It participates in the Cori cycle which integrates with glucose metabolism and works alongside lactate dehydrogenase (LDH) to shuttle lactate for gluconeogenesis in the liver. MCT2's operation affects cellular energy balance and tissue responses to metabolic fluctuations.

MCT2 has connections to cancer and neurological disorders such as epilepsy. In cancer altered MCT2 expression affects tumor metabolism and progression interacting with hypoxia-inducible factor-1 (HIF-1) which controls glycolytic enzymes. In neurological conditions deficient or excessive lactate transport by MCT2 could impact neuronal excitability and energy balance potentially linking it to disease-related proteins like glutamate receptors.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Proton-coupled monocarboxylate symporter. Catalyzes the rapid transport across the plasma membrane of monocarboxylates such as L-lactate, pyruvate and ketone bodies, acetoacetate, beta-hydroxybutyrate and acetate (PubMed : 32415067, PubMed : 9786900). Dimerization is functionally required and both subunits work cooperatively in transporting substrate (PubMed : 32415067).
See full target information SLC16A7
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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Biological & pharmaceutical bulletin 47:764-770 PubMed38569835

2024

Monocarboxylate Transporters 1 and 2 Are Responsible for L-Lactate Uptake in Differentiated Human Neuroblastoma SH-SY5Y Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Tomoya Sakuma,Yuto Mukai,Atsushi Yamaguchi,Yudai Suganuma,Keisuke Okamoto,Ayako Furugen,Katsuya Narumi,Shuhei Ishikawa,Yoshitaka Saito,Masaki Kobayashi

Pharmaceutics 15: PubMed37631275

2023

Distribution of Monocarboxylate Transporters in Brain and Choroid Plexus Epithelium.

Applications

Unspecified application

Species

Unspecified reactive species

Masaki Ueno,Yoichi Chiba,Ryuta Murakami,Yumi Miyai,Koichi Matsumoto,Keiji Wakamatsu,Genta Takebayashi,Naoya Uemura,Ken Yanase

Scientific reports 13:1501 PubMed36707650

2023

Monocarboxylate transporter 4 involves in energy metabolism and drug sensitivity in hypoxia.

Applications

Unspecified application

Species

Unspecified reactive species

Atsushi Yamaguchi,Yuto Mukai,Tomoya Sakuma,Katsuya Narumi,Ayako Furugen,Yuma Yamada,Masaki Kobayashi

Biopharmaceutics & drug disposition 43:183-191 PubMed36104287

2022

Involvement of SLC16A1/MCT1 and SLC16A3/MCT4 in l-lactate transport in the hepatocellular carcinoma cell line.

Applications

Unspecified application

Species

Unspecified reactive species

Yuto Mukai,Atsushi Yamaguchi,Tomoya Sakuma,Takanobu Nadai,Ayako Furugen,Katsuya Narumi,Masaki Kobayashi

Scientific reports 6:37955 PubMed27897253

2016

Hyperglycaemia and Pseudomonas aeruginosa acidify cystic fibrosis airway surface liquid by elevating epithelial monocarboxylate transporter 2 dependent lactate-H secretion.

Applications

ICC/IF

Species

Human

James Peter Garnett,Kameljit K Kalsi,Mirko Sobotta,Jade Bearham,Georgina Carr,Jason Powell,Malcolm Brodlie,Christopher Ward,Robert Tarran,Deborah L Baines
View all publications
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