AB9847

Anti-MDC antibody

Name: Anti-MDC antibody (ab9847) | Abcam
Brand: Abcam Limited
SKU: AB9847
Price: 535 USD
Availability: InStock
Rating: 4 (1 reviews)

(1 Review)

(11 Publications)

Rabbit Polyclonal MDC antibody. Suitable for WB, sELISA and reacts with Recombinant full length protein - Human samples. Cited in 11 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CCL22.

View Alternative Names

MDC, SCYA22, A-152E5.1, CCL22, C-C motif chemokine 22, CC chemokine STCP-1, MDC(1-69), Macrophage-derived chemokine, Small-inducible cytokine A22, Stimulated T-cell chemotactic protein 1

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

Unknown

Light chain type

unknown

Carrier free

Reacts with

Human

Applications

WB, sELISA

applications

Immunogen

Recombinant Full Length Protein corresponding to Human CCL22.

O00626

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "sELISA-species-checked": "predicted", "sELISA-species-dilution-info": "", "sELISA-species-notes": "" }, "Recombinant full length protein - Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "0.1-0.2 µg/mL", "WB-species-notes": "<p></p>", "sELISA-species-checked": "guaranteed", "sELISA-species-dilution-info": "0.5-2 µg/mL", "sELISA-species-notes": "<p></p>" } } }

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Product details

This product is no longer batch tested in IHC, for an IHC validated antibody please see ab124768

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Properties and storage information

Form

Lyophilized

Reconstitution

Reconstitute with 200µl of sterile water. Please note that if you receive this product in liquid form it has already been reconstituted as described and no further reconstitution is necessary.

Purification technique

Affinity purification Immunogen

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MDC also known as CCL22 or macrophage-derived chemokine is a small protein involved in immune system signaling. The molecular mass of MDC is approximately 8 kDa. It is expressed in various tissues including lymph nodes thymus and lungs where it mainly acts to regulate immune cell movement. Researchers commonly study this target using MDC assays and CCL22 ELISA to better understand its functions and expression patterns.

Biological function summary

MDC interacts with immune cells to mediate responses such as chemotaxis. It binds to the CCR4 receptor which is found on T cells and other immune cells. MDC does not require complex formation to function; it works independently to attract specific cell types. This chemokine provides a way for immune cells to navigate to sites of inflammation or infection.

Pathways

MDC plays a significant role in inflammatory and immune response pathways. It is integrally linked with the chemokine signaling pathway where it works along with other chemokines to guide immune responses. MDC is related to proteins like CCR4 and other chemokines in these pathways facilitating communication between cells during immune responses and maintaining homeostasis.

MDC is implicated in conditions such as allergic responses and autoimmune diseases. Its interaction with CCR4 connects it to disorders like asthma and atopic dermatitis where excessive immune cell recruitment leads to inflammation. Studying MDC levels through macrophage assays and chemokine ELISAs can provide insights into its role in these diseases and help develop potential therapeutic strategies.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active.

See full target information CCL22

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Publications (11)

Recent publications for all applications. Explore the full list and refine your search

Journal of cell communication and signaling 19:e12060 PubMed39720765

2024

M2-polarized tumor-associated macrophage-secreted exosomal lncRNA NEAT1 upregulates galectin-3 by recruiting KLF5 and promotes HCC immune escape.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Yuan,Qigang Sun,Xiaodan Zhu,Bo Li,Yongping Zou,Zhehao Liu

PloS one 17:e0263997 PubMed35176085

2022

LncRNA HOTAIR promotes proliferation, invasion and migration in NSCLC cells via the CCL22 signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Hanlin Liang,Jiewen Peng

Bioengineered 12:11277-11287 PubMed34874224

2021

MicroRNA-23a-3p influences the molecular mechanism of gastric cancer cells via CCL22/PI3K/Akt axis.

Applications

Unspecified application

Species

Unspecified reactive species

Zhipeng Jiang,Hua Chen,Min Su,Limian Wu,Xinpei Yu,Zichuan Liu

Liver international : official journal of the International Association for the Study of the Liver 40:1327-1338 PubMed32187823

2020

HBV promotes the recruitment of IL-17 secreting T cells via chemokines CCL22 and CCL17.

Applications

Unspecified application

Species

Unspecified reactive species

Ka Zhang,Yanqiong Liu,Xiaoan Yang,Haixia Sun,Xin Shu,Yeqiong Zhang,Hong Cao,Mengdi Wu,Nan Liu,Yong Zou,Qihuan Xu,Gang Li

Experimental and therapeutic medicine 19:2127-2132 PubMed32104275

2020

Anti-CCL22 increases regulatory T cells in CD4 T cells of rheumatoid arthritis patients via STAT5 pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Ling Wang,Ling Wang,Ping Hao,Qiwei Cao,Zhenxian Zhang

Oncoimmunology 7:e1433517 PubMed29872564

2018

C-C motif chemokine 22 predicts postoperative prognosis and adjuvant chemotherapeutic benefits in patients with stage II/III gastric cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Songyang Wu,Hongyong He,Hao Liu,Yifan Cao,Rochen Li,Heng Zhang,He Li,Zhenbin Shen,Jing Qin,Jiejie Xu

The Prostate 76:1095-105 PubMed27199259

2016

Functional reprogramming of human prostate cancer to promote local attraction of effector CD8(+) T cells.

Applications

Unspecified application

Species

Unspecified reactive species

Ravikumar Muthuswamy,John M Corman,Kathryn Dahl,Gurkamal S Chatta,Pawel Kalinski

Biochimica et biophysica acta 1852:2494-503 PubMed26303640

2015

Activated STING enhances Tregs infiltration in the HPV-related carcinogenesis of tongue squamous cells via the c-jun/CCL22 signal.

Applications

Unspecified application

Species

Unspecified reactive species

Ding Liang,Huang Xiao-Feng,Dong Guan-Jun,Hu Er-Ling,Chen Sheng,Wang Ting-Ting,Hu Qin-Gang,Ni Yan-Hong,Hou Ya-Yi

Modern pathology : an official journal of the Unit 27:1345-54 PubMed24633193

2014

A novel immunohistochemical classifier to distinguish Hodgkin lymphoma from ALK anaplastic large cell lymphoma.

Applications

Unspecified application

Species

Unspecified reactive species

Claudia Döring,Martin-Leo Hansmann,Claudio Agostinelli,Pier P Piccaluga,Fabio Facchetti,Stefano Pileri,Ralf Küppers,Sebastian Newrzela,Sylvia Hartmann

PloS one 8:e76379 PubMed24124553

2013

Tumor secretion of CCL22 activates intratumoral Treg infiltration and is independent prognostic predictor of breast cancer.

Applications

IHC-P

Species

Human

Ya-Qing Li,Fang-Fang Liu,Xin-Min Zhang,Xiao-Jing Guo,Mei-Jing Ren,Li Fu

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-MDC antibody

Key facts

Host species

Clonality

Isotype

Light chain type

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Product details

Properties and storage information

Form

Reconstitution

Purification technique

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (11)

Product promise