Rabbit Polyclonal MDGA1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human MDGA1 aa 500-650.
Images
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)- Form
Liquid
- Clonality
Polyclonal
Immunogen
- Recombinant Fragment Protein within Human MDGA1 aa 500-650. The exact immunogen used to generate this antibody is proprietary information. Database link Q8NFP4
Reactivity data
Select an application| IHC-P | ICC/IF | |
|---|---|---|
| Human | Tested | Tested |
| Mouse | Predicted | Predicted |
| Rat | Predicted | Predicted |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/50.00000 - 1/200.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat | Dilution info - | Notes - |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1.00000-4.00000 µg/mL | Notes Fixation/Permeabilization: PFA/Triton X-100. |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat | Dilution info - | Notes - |
Target data
Function
Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity). Plays a role in the formation or maintenance of inhibitory synapses. May function by inhibiting the activity of NLGN2.
Alternative names
MAMDC3, MDGA1, MAM domain-containing glycosylphosphatidylinositol anchor protein 1, GPI and MAM protein, Glycosylphosphatidylinositol-MAM, MAM domain-containing protein 3, GPIM
Recommended products
Rabbit Polyclonal MDGA1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human MDGA1 aa 500-650.
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)- Form
Liquid
- Clonality
Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human MDGA1 aa 500-650. The exact immunogen used to generate this antibody is proprietary information. Database link Q8NFP4
- Purification technique
Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
Blue Ice
- Appropriate short-term storage duration
1-2 weeks
- Appropriate short-term storage conditions
+4°C
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
MDGA1 also known as MAM domain-containing glycosylphosphatidylinositol anchor 1 is a neural cell adhesion molecule. It weighs approximately 117 kDa and is expressed primarily in the nervous system. Its primary function involves interaction with other cell adhesion molecules influencing cellular signaling and connections. MDGA1 is also known for its expression in the developing brain playing roles in neuronal migration and axon guidance.
- Biological function summary
MDGA1 modulates interactions in the nervous system. It acts as part of a complex involved in cell adhesion processes affecting the synaptic organization and function. By modulating these interactions MDGA1 influences neural connectivity and neuronal network formation essential for proper brain development.
- Pathways
MDGA1 participates in neural development and synapse formation pathways. It interacts with proteins like neuroligins which are important in synapse establishment and maintenance. By engaging with these pathways MDGA1 plays a role in the regulation of synaptic adhesive dynamics contributing to the overall neural network architecture.
- Associated diseases and disorders
MDGA1 shows a connection to autism spectrum disorders and schizophrenia. Changes in MDGA1 expression or function can impact neuronal connectivity potentially contributing to the manifestation of these disorders. MDGA1's interactions with NLGN1 and neurexins both involved in synaptic organization further link its role to neurodevelopmental conditions emphasizing its importance in maintaining normal cognitive function.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Immunocytochemistry/ Immunofluorescence - Anti-MDGA1 antibody (ab204180)
Immunofluorescent analysis of PFA-fixed,Triton X-100 permeabilized U-251 MG cells labeling MDGA1 with ab204180 at 4 μg/ml (green).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MDGA1 antibody (ab204180)
Immunohistochemical analysis of paraffin-embedded Human kidney tissue labeling MDGA1 with ab204180 at 1/50 dilution.
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Product protocols
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