Rabbit Polyclonal MDGA2 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human MAM domain-containing glycosylphosphatidylinositol anchor protein 2 aa 500-700.
IgG
Rabbit
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)
Liquid
Polyclonal
IHC-P | ICC/IF | |
---|---|---|
Human | Tested | Tested |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/50.00000 - 1/200.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1.00000-4.00000 µg/mL | Notes Recommend PFA Fixation and Triton X-100 treatment |
MAMDC1, UNQ8188/PRO23197, UNQ8188/PRO23197, MAMDC1, MDGA2, MAM domain-containing glycosylphosphatidylinositol anchor protein 2, MAM domain-containing protein 1
Rabbit Polyclonal MDGA2 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human MAM domain-containing glycosylphosphatidylinositol anchor protein 2 aa 500-700.
IgG
Rabbit
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)
Liquid
Polyclonal
Affinity purification Immunogen
Blue Ice
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
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This supplementary information is collated from multiple sources and compiled automatically.
MDGA2 also known as MAM Domain-Containing Glycosylphosphatidylinositol Anchor 2 is a neural cell adhesion molecule that belongs to the Ig superfamily. This protein has a mass of approximately 109 kDa and is expressed mainly in the brain particularly in regions important for learning and memory processes. MDGA2 plays a mechanical role in neuronal development by interacting with axonal growth cones and facilitating cell-cell communication through its extracellular MAM domain.
MDGA2 participates in synaptic modulation and plasticity. It acts outside of synapses modulating interactions between molecules involved in synaptogenesis. MDGA2 is not known to form a complex by itself but it is often functionally linked with neuroligins and other synapse-related proteins which impact neural circuitry organization. Its activity highlights its role in regulating neuronal connectivity influencing basic properties of synaptic transmission.
MDGA2 plays significant roles in the glutamatergic signaling and neuronal development pathways. It impacts the way in which neurons form connections and strengthen synapses over time processes that are vital for cognitive functions. In these pathways MDGA2 interacts with proteins such as neurexins (NRXN) to stabilize or destabilize synaptic contacts adjusting neuronal network activity accordingly.
Abnormal MDGA2 function relates to neurodevelopmental disorders such as autism spectrum disorder and schizophrenia. Changes in MDGA2 levels or structure can disrupt normal synaptic function and plasticity possibly leading to altered connectivity patterns in the brain. Through these disorders MDGA2 is often investigated alongside other proteins like neuregulin 1 (NRG1) due to their combined effects on neurodevelopment and synaptic maintenance.
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Immunofluorescent staining of Human cell line U-251MG shows positivity in cytoplasm. Recommended concentration of ab121164 1-4 µg/ml. Cells treated with PFA/Triton X-100.
ab121164 at 1/20 dilution staining MDGA2 in Paraffin-embedded Human testis tissue by Immunohistochemistry.
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