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Rabbit Polyclonal MDGA2 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human MAM domain-containing glycosylphosphatidylinositol anchor protein 2 aa 500-700.

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Images

Immunocytochemistry/ Immunofluorescence - Anti-MDGA2 antibody (AB121164), expandable thumbnail
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MDGA2 antibody (AB121164), expandable thumbnail

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Recombinant Fragment Protein within Human MAM domain-containing glycosylphosphatidylinositol anchor protein 2 aa 500-700. The exact immunogen used to generate this antibody is proprietary information. Database link Q7Z553

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
IHC-PICC/IF
Human
Tested
Tested

Tested
Tested

Species

Human

Dilution info

1/50.00000 - 1/200.00000

Notes

Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Tested
Tested

Species

Human

Dilution info

1.00000-4.00000 µg/mL

Notes

Recommend PFA Fixation and Triton X-100 treatment

Target data

Function

May be involved in cell-cell interactions.

Alternative names

Recommended products

Rabbit Polyclonal MDGA2 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human MAM domain-containing glycosylphosphatidylinositol anchor protein 2 aa 500-700.

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Recombinant Fragment Protein within Human MAM domain-containing glycosylphosphatidylinositol anchor protein 2 aa 500-700. The exact immunogen used to generate this antibody is proprietary information. Database link Q7Z553
Purification technique

Affinity purification Immunogen

Concentration
Loading...

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

MDGA2 also known as MAM Domain-Containing Glycosylphosphatidylinositol Anchor 2 is a neural cell adhesion molecule that belongs to the Ig superfamily. This protein has a mass of approximately 109 kDa and is expressed mainly in the brain particularly in regions important for learning and memory processes. MDGA2 plays a mechanical role in neuronal development by interacting with axonal growth cones and facilitating cell-cell communication through its extracellular MAM domain.

Biological function summary

MDGA2 participates in synaptic modulation and plasticity. It acts outside of synapses modulating interactions between molecules involved in synaptogenesis. MDGA2 is not known to form a complex by itself but it is often functionally linked with neuroligins and other synapse-related proteins which impact neural circuitry organization. Its activity highlights its role in regulating neuronal connectivity influencing basic properties of synaptic transmission.

Pathways

MDGA2 plays significant roles in the glutamatergic signaling and neuronal development pathways. It impacts the way in which neurons form connections and strengthen synapses over time processes that are vital for cognitive functions. In these pathways MDGA2 interacts with proteins such as neurexins (NRXN) to stabilize or destabilize synaptic contacts adjusting neuronal network activity accordingly.

Associated diseases and disorders

Abnormal MDGA2 function relates to neurodevelopmental disorders such as autism spectrum disorder and schizophrenia. Changes in MDGA2 levels or structure can disrupt normal synaptic function and plasticity possibly leading to altered connectivity patterns in the brain. Through these disorders MDGA2 is often investigated alongside other proteins like neuregulin 1 (NRG1) due to their combined effects on neurodevelopment and synaptic maintenance.

Product promise

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2 product images

  • Immunocytochemistry/ Immunofluorescence - Anti-MDGA2 antibody (ab121164), expandable thumbnail

    Immunocytochemistry/ Immunofluorescence - Anti-MDGA2 antibody (ab121164)

    Immunofluorescent staining of Human cell line U-251MG shows positivity in cytoplasm. Recommended concentration of ab121164 1-4 µg/ml. Cells treated with PFA/Triton X-100.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MDGA2 antibody (ab121164), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MDGA2 antibody (ab121164)

    ab121164 at 1/20 dilution staining MDGA2 in Paraffin-embedded Human testis tissue by Immunohistochemistry.

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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