Rabbit Polyclonal MECP2 phospho S421 antibody. Suitable for WB and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human MECP2 phospho S421.
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- Frontiers in pharmacology 13:9728282022Cannabidiol prevents methamphetamine-induced neurotoxicity by modulating dopamine receptor D1-mediated calcium-dependent phosphorylation of methyl-CpG-binding protein 2.Applications:Unspecified applicationReactive species:Unspecified reactive speciesBaoyu Shen,Ruilin Zhang,Genmeng Yang,Yanxia Peng,Qianyun Nie,Hao Yu,Wenjuan Dong,Bingzheng Chen,Chunhui Song,Yan Tian,Lixiang Qin,Junjie Shu,Shijun Hong,Lihua LiPubMed 36147353
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7.5
Constituents: HEPES, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.01% BSA- Form
Liquid
- Clonality
Polyclonal
Immunogen
- Synthetic Peptide within Human MECP2 phospho S421. The exact immunogen used to generate this antibody is proprietary information. Database link P51608
Reactivity data
Select an application| WB | |
|---|---|
| Human | Predicted |
| Mouse | Tested |
| Rat | Predicted |
| Primates | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1/1000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Rat, Human, Primates | Dilution info - | Notes - |
Target data
Function
Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).
Alternative names
Methyl-CpG-binding protein 2, MeCp-2 protein, MeCp2, MECP2
Recommended products
Rabbit Polyclonal MECP2 phospho S421 antibody. Suitable for WB and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human MECP2 phospho S421.
Alternative names
Methyl-CpG-binding protein 2, MeCp-2 protein, MeCp2, MECP2
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7.5
Constituents: HEPES, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.01% BSA- Form
Liquid
- Clonality
Polyclonal
- Immunogen
- Synthetic Peptide within Human MECP2 phospho S421. The exact immunogen used to generate this antibody is proprietary information. Database link P51608
- Purification technique
Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
Blue Ice
- Appropriate short-term storage duration
1-2 weeks
- Appropriate short-term storage conditions
+4°C
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
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1 product image
Western blot - Anti-MeCP2 (phospho S421) antibody (ab254050)
All lanes: Western blot - Anti-MeCP2 (phospho S421) antibody (ab254050) at 1/1000 dilution
All lanes: Mouse whole brain lysate
Predicted band size: 52 kDa
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Product protocols
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