AB181494

Anti-MEF2A antibody [2F9H2]

Name: Anti-MEF2A antibody [2F9H2] (ab181494) | Abcam
Brand: Abcam Limited
SKU: AB181494
Price: 520 USD
Availability: InStock

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(3 Publications)

Mouse Monoclonal MEF2A antibody. Suitable for WB and reacts with Recombinant fragment - Human, Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MEF2A aa 350 to C-terminus.

View Alternative Names

MEF2, MEF2A, Myocyte-specific enhancer factor 2A, Serum response factor-like protein 1

2 Images

Supplier Data

Western blot - Anti-MEF2A antibody [2F9H2] (AB181494)

Expected MWt is 38 kDa.

All lanes:

Western blot - Anti-MEF2A antibody [2F9H2] (ab181494) at 1/500 dilution

All lanes:

MEF2A (AA: 391-497) recombinant protein

Predicted band size: 55 kDa

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Supplier Data

Western blot - Anti-MEF2A antibody [2F9H2] (AB181494)

All lanes:

Western blot - Anti-MEF2A antibody [2F9H2] (ab181494) at 1/500 dilution

Lane 1:

HEK293 cell lysate

Lane 2:

MEF2A (AA: 391-497)-hIgGFc transfected HEK293 cell lysate

Predicted band size: 55 kDa

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Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

2F9H2

Isotype

IgG1

Carrier free

Reacts with

Human

Applications

applications

Immunogen

Recombinant Fragment Protein within Human MEF2A aa 350 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q02078

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Recombinant fragment - Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein G

Purification notes

Purified from tissue culture supernatant.

Storage buffer

Preservative: 0.05% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MEF2A or Myocyte Enhancer Factor 2A is a transcription factor involved in regulating gene expression. MEF2A is approximately 55 kDa in size and is expressed in a variety of tissues including muscle brain and heart. It is part of the MEF2 family of transcription factors which all share a similar MADS-box/MEF2 domain structure. MEF2A binds to DNA and influences the transcription of genes involved in muscle differentiation and development.

Biological function summary

MEF2A participates in transcriptional regulation as part of a larger complex that includes other regulatory proteins. This transcription factor plays an essential role in the development and function of muscles. It activates the transcription of genes necessary for muscle fiber formation and adaptation. MEF2A also influences the expression of genes related to neuronal survival and plasticity impacting cognitive function and memory in the brain.

Pathways

MEF2A is involved in both the MAPK/ERK and PI3K/Akt pathways which are significant for cellular growth survival and differentiation. MEF2A interacts with proteins like MAPK and PI3K impacting these signaling pathways that regulate cell proliferation and apoptosis. This interaction highlights its role in cellular response to external stimuli and stress signals positioning MEF2A as an important factor in cell fate decisions.

Mutations or dysregulation of MEF2A are connected to cardiovascular diseases particularly coronary artery disease. MEF2A mutations can disrupt normal transcriptional regulation leading to impaired cardiovascular function. Additionally alterations in MEF2A function are linked to neurodegenerative disorders such as Alzheimer's disease where it may interact with proteins including Tau and amyloid precursor protein influencing neuronal health and survival.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
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Target data

Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter.

See full target information MEF2A

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 15:17364 PubMed40389489

2025

Inhibitory effects of high extracellular L-glutamate concentrations on skeletal myogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Himiko Ban,Koji Nobe,Soushi Kobayashi

Amino acids 51:1657-1666 PubMed31729551

2019

Methionine restriction at the post-weanling period promotes muscle fiber transition in piglets and improves intramuscular fat content in growing-finishing pigs.

Applications

Unspecified application

Species

Unspecified reactive species

Li Wu,Haiwen Zhang,Lin Na,Xihong Zhou,Xiang Li,Yurong Zhao,Zhen Wen,Qinghua He

Endocrinology 156:1303-15 PubMed25646713

2015

Brain innate immunity regulates hypothalamic arcuate neuronal activity and feeding behavior.

Applications

Unspecified application

Species

Unspecified reactive species

Wagner L Reis,Chun-Xia Yi,Yuanqing Gao,Mathias H Tschöp,Javier E Stern

View all publications

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