Rabbit Polyclonal MEOX 2 antibody. Suitable for IHC-P, WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human MEOX2 aa 50-200.
Images
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human MEOX2 aa 50-200. The exact immunogen used to generate this antibody is proprietary information. Database link P50222
Reactivity data
Select an application| IHC-P | WB | |
|---|---|---|
| Human | Tested | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/1000.00000 - 1/2500.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 0.04000-0.40000 µg/mL | Notes - |
Target data
Function
Mesodermal transcription factor that plays a key role in somitogenesis and somitogenesis and limb muscle differentiation (By similarity). Required during limb development for normal appendicular muscle formation and for the normal regulation of myogenic genes (By similarity). May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle (By similarity). Also acts as a negative regulator of angiogenesis (PubMed:17074759, PubMed:20516212, PubMed:22206000). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation (PubMed:17074759, PubMed:22206000). While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner (PubMed:22206000). Together with TCF15, regulates transcription in heart endothelial cells to regulate fatty acid transport across heart endothelial cells (By similarity).
Alternative names
GAX, MOX2, MEOX2, Homeobox protein MOX-2, Growth arrest-specific homeobox, Mesenchyme homeobox 2
Recommended products
Rabbit Polyclonal MEOX 2 antibody. Suitable for IHC-P, WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human MEOX2 aa 50-200.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human MEOX2 aa 50-200. The exact immunogen used to generate this antibody is proprietary information. Database link P50222
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The MEOX2 protein also known as Mesenchyme Homeobox 2 or GAX is a homeobox-containing transcription factor with a mass of approximately 34 kDa. MEOX2 is expressed in developing mesoderm and neural crest during embryonic development. In adults its expression continues in various tissues including skeletal muscle and some parts of the central nervous system. This expression pattern indicates its role in both early development and maintenance of specific tissues.
- Biological function summary
MEOX2 regulates the differentiation of mesodermal cells and contributes to skeletal muscle development. It acts as a transcription factor influencing the expression of a variety of downstream genes involved in cell cycle control and tissue morphogenesis. MEOX2 functions within a complex network of homeobox genes working together with other transcription factors to modulate cellular differentiation and organogenesis.
- Pathways
The MEOX2 protein plays a significant role in the Wnt signaling and TGF-beta pathways. These pathways are important in cellular growth differentiation and development processes. MEOX2 interacts with proteins such as beta-catenin in the Wnt pathway influencing gene transcription linked to cell proliferation and differentiation. This coordination ensures the proper development and function of tissues where MEOX2 is expressed.
- Associated diseases and disorders
MEOX2 involvement has been linked to vascular diseases and muscular dystrophies. Altered expression of MEOX2 can disrupt vascular endothelium function contributing to the progression of vascular diseases like atherosclerosis. In muscular dystrophies MEOX2 interacts with other proteins such as myogenin and MyoD potentially affecting muscle cell differentiation and regeneration. Understanding these interactions and MEOX2's roles could provide insights into therapeutic targets for these conditions.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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5 product images
Western blot - Anti-MEOX 2 antibody (ab262916)
All lanes: Western blot - Anti-MEOX 2 antibody (ab262916) at 0.4 µg/mL
Lane 1: Vector-only transfected HEK-293 cell lysate (control)
Lane 2: MEOX2 over expression HEK-293 cell lysate
Predicted band size: 34 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MEOX 2 antibody (ab262916)
Paraffin-embedded Human placenta tissue stained for MEOX 2 using ab262916 at 1/1000 dilution in immunohistochemical analysis.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MEOX 2 antibody (ab262916)
Paraffin-embedded Human prostate tissue stained for MEOX 2 using ab262916 at 1/1000 dilution in immunohistochemical analysis.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MEOX 2 antibody (ab262916)
Paraffin-embedded Human cerebral cortex tissue stained for MEOX 2 using ab262916 at 1/1000 dilution in immunohistochemical analysis.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MEOX 2 antibody (ab262916)
Paraffin-embedded Human liver tissue stained for MEOX 2 using ab262916 at 1/1000 dilution in immunohistochemical analysis.
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