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AB42743

Anti-Meprin beta antibody

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(2 Publications)

Rabbit Polyclonal Meprin beta antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications.

View Alternative Names

Meprin A subunit beta, Endopeptidase-2, Meprin B, N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta, PABA peptide hydrolase, PPH beta, MEP1B

1 Images
Western blot - Anti-Meprin beta antibody (AB42743)
  • WB

Unknown

Western blot - Anti-Meprin beta antibody (AB42743)

All lanes:

Western blot - Anti-Meprin beta antibody (ab42743) at 1/1000 dilution

Lane 1:

recombinant Human Meprin-alpha at 0.05 µg

Lane 2:

negative control

Lane 3:

recombinant Human Meprin-beta at 0.05 µg

Predicted band size: 80 kDa

Observed band size: 84 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

Specificity

Meprin beta antibody Math Domain recognizes meprin beta but not alpha subunits.

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p>1/1000 for using colorimetric substrates such as BCIP/NBT. WB: 1/5000 for chemiluminescent substrates. Higher concentrations of antibody may be needed for samples from more distantly related species. Dilution optimised using Chromogenic detection.</p>" } } }

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Peptide-affinity purified.
Storage buffer
Preservative: 0.05% Sodium azide Constituents: 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Target data

Membrane metallopeptidase that sheds many membrane-bound proteins. Exhibits a strong preference for acidic amino acids at the P1' position. Known substrates include : FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components. Cleaves also the amyloid precursor protein/APP, thereby releasing neurotoxic amyloid beta peptides (PubMed : 27180357).
See full target information MEP1B

Publications (2)

Recent publications for all applications. Explore the full list and refine your search

British journal of pharmacology 177:2872-2885 PubMed32072633

2020

Meprin-α (Mep1A) enhances TNF-α secretion by mast cells and aggravates abdominal aortic aneurysms.

Applications

Unspecified application

Species

Unspecified reactive species

Ran Gao,Duan Liu,Wenjun Guo,Weipeng Ge,Tianfei Fan,Bolun Li,Pan Gao,Bin Liu,Yuehong Zheng,Jing Wang

Autophagy 12:976-98 PubMed27123926

2016

Persistent activation of autophagy in kidney tubular cells promotes renal interstitial fibrosis during unilateral ureteral obstruction.

Applications

Unspecified application

Species

Unspecified reactive species

Man J Livingston,Han-Fei Ding,Shuang Huang,Joseph A Hill,Xiao-Ming Yin,Zheng Dong
View all publications

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